Dapk3 MGI Mouse Gene Detail - MGI:1203520 - death-associated protein kinase 3

Symbol

Dapk3
Name

death-associated protein kinase 3
Synonyms

ZIP kinase

Feature Type

protein coding gene
IDs

MGI:1203520
NCBI Gene: 13144
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:81018839-81029031 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

3 experiments

SNPs within 2kb

268 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1203520	protein coding gene	Chr10:81018821-81029031 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017541	protein coding gene	Chr10:81880646-81890216 (+)
A/J	MGP_AJ_G0017519	protein coding gene	Chr10:78981021-78993391 (+)
AKR/J	MGP_AKRJ_G0017480	protein coding gene	Chr10:81155878-81167616 (+)
BALB/cJ	MGP_BALBcJ_G0017481	protein coding gene	Chr10:79201411-79212104 (+)
C3H/HeJ	MGP_C3HHeJ_G0017304	protein coding gene	Chr10:81236973-81258047 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017935	protein coding gene	Chr10:84691326-84706489 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015624	protein coding gene	Chr10:75182358-75192394 (+)
CAST/EiJ	MGP_CASTEiJ_G0016871	protein coding gene	Chr10:81478178-81490751 (+)
CBA/J	MGP_CBAJ_G0017276	protein coding gene	Chr10:87985379-88001701 (+)
DBA/2J	MGP_DBA2J_G0017382	protein coding gene	Chr10:78191250-78201294 (+)
FVB/NJ	MGP_FVBNJ_G0017375	protein coding gene	Chr10:77427201-77441931 (+)
LP/J	MGP_LPJ_G0017453	protein coding gene	Chr10:82330444-82345065 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017402	protein coding gene	Chr10:89859688-89869356 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017976	protein coding gene	Chr10:81144483-81157933 (+)
PWK/PhJ	MGP_PWKPhJ_G0016652	protein coding gene	Chr10:78081987-78091539 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016442	protein coding gene	Chr10:80099182-80110024 (+)
WSB/EiJ	MGP_WSBEiJ_G0016931	protein coding gene	Chr10:81182749-81195684 (+)

Human Ortholog

DAPK3, death associated protein kinase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DAPK3, death associated protein kinase 3
Synonyms

DLK, ZIP, ZIPK
Links

HGNC:2676

NCBI Gene ID: 1613

neXtProt AC: NX_O43293

UniProt: O43293
Chr Location

19p13.3; chr19:3958453-3971123 (-) GRCh38

MGI Vertebrate Homology

Dapk3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DAPK3
Protein SuperFamily

Integrin-linked_kinase
Gene Tree

Dapk3

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Phenotype Summary

7 phenotypes from 2 alleles in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

7
Targeted

3
Genomic Mutations

1 involving Dapk3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene-trapped allele exhibit embryonic lethality after blastocyst implantation.

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All GO Annotations

91
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

10
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dapk3

ZFIN dapk3

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All Sequences

70
RefSeq

14
UniProt

5
CCDS

CCDS24045.1

Ensembl

ENSMUSG00000034974 (Evidence)
NCBI Gene

13144

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034974	Ensembl Gene Model \| MGI Sequence Detail	10193	C57BL/6J	± kb
transcript	ENSMUST00000178422	Ensembl \| MGI Sequence Detail	1730	Not Applicable
polypeptide	ENSMUSP00000137333	Ensembl \| MGI Sequence Detail	448	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000006278 death-associated protein kinase 3

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR042870 DAPK3, catalytic domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 10

cDNA 10

Microarray probesets 4

Summaries

All 55

Developmental Gene Expression 2

Gene Ontology 16

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dapk3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94710	Chr10:81018234-81018244 (+)	-600 bp
Tssr3283	Chr10:81018261-81018296 (+)	-560 bp
Tssr94711	Chr10:81018834-81018882 (+)	19 bp
Tssr94712	Chr10:81018890-81018904 (+)	58 bp
Tssr94713	Chr10:81019056-81019107 (+)	243 bp
Tssr94714	Chr10:81019118-81019163 (+)	302 bp
Tssr94715	Chr10:81028320-81028352 (+)	9,497 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24