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Dffa Gene Detail
Summary
  • Symbol
    Dffa
  • Name
    DNA fragmentation factor, alpha subunit
  • Synonyms
    A330085O09Rik, DFF35, Dff45, ICAD-L, ICAD-S
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196227
    NCBI Gene: 13347
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:149188603-149205104 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    205 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196227
 protein coding gene Chr4:149188599-149205110 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029133
 protein coding gene Chr4:152910262-152934271 (+)
A/J MGP_AJ_G0029098
 protein coding gene Chr4:146546358-146561658 (+)
AKR/J MGP_AKRJ_G0029046
 protein coding gene Chr4:150557592-150576485 (+)
BALB/cJ MGP_BALBcJ_G0029114
 protein coding gene Chr4:147054950-147070543 (+)
C3H/HeJ MGP_C3HHeJ_G0028835
 protein coding gene Chr4:151115938-151136814 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029563
 protein coding gene Chr4:158427995-158455838 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026809
 protein coding gene Chr4:138973127-138989522 (+)
CAST/EiJ MGP_CASTEiJ_G0028248
 protein coding gene Chr4:148331422-148351302 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0028946
 protein coding gene Chr4:146659917-146679195 (+)
FVB/NJ MGP_FVBNJ_G0028910
 protein coding gene Chr4:145761918-145779905 (+)
LP/J MGP_LPJ_G0029036
 protein coding gene Chr4:152856573-152874638 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028937
 protein coding gene Chr4:166323734-166352698 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029595
 protein coding gene Chr4:151049599-151072091 (+)
PWK/PhJ MGP_PWKPhJ_G0027968
 protein coding gene Chr4:142655679-142672603 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027802
 protein coding gene Chr4:145288695-145305519 (+)
WSB/EiJ MGP_WSBEiJ_G0028328
 protein coding gene Chr4:151209350-151228310 (+)



Homology
more
  • Human Ortholog
    DFFA, DNA fragmentation factor subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DFFA, DNA fragmentation factor subunit alpha
  • Synonyms
    DFF1, DFF-45, ICAD
  • Links
    NCBI Gene ID: 1676
    neXtProt AC: NX_O00273
    UniProt: O00273

  • Chr Location
    1p36.22; chr1:10456522-10472529 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show increased resistance to apoptosis in response to several apoptotic stimuli, enhanced spatial learning and memory, higher granule cell density and total granule cell number in the dentate gyrus, and resistance to kainic acid-induced CA3 neuronal cell death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    10
  • cDNA Data
    48
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028974 Ensembl Gene Model | MGI Sequence Detail 16502 C57BL/6J ±  kb
    transcript ENSMUST00000030816 Ensembl | MGI Sequence Detail 2457 Not Applicable  
    polypeptide ENSMUSP00000030816 Ensembl | MGI Sequence Detail 331 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 48
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2443522
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:45015 Enari M, et al., A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD [see comments]. Nature. 1998 Jan 1;391(6662):43-50
    • Latest
      J:198289 Errami Y, et al., ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability. PLoS One. 2013;8(2):e57871
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory