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Hes2 Gene Detail
Summary
  • Symbol
    Hes2
  • Name
    hes family bHLH transcription factor 2
  • Synonyms
    HES-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098624
    NCBI Gene: 15206
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:152243324-152246926 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 82.92 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    210 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098624
 protein coding gene Chr4:152243324-152246926 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029174
 protein coding gene Chr4:156258649-156262250 (+)
A/J MGP_AJ_G0029139
 protein coding gene Chr4:149708490-149712092 (+)
AKR/J MGP_AKRJ_G0029087
 protein coding gene Chr4:153776685-153780287 (+)
BALB/cJ MGP_BALBcJ_G0029155
 protein coding gene Chr4:150181678-150185280 (+)
C3H/HeJ MGP_C3HHeJ_G0028876
 protein coding gene Chr4:154346288-154349890 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029604
 protein coding gene Chr4:161858064-161861666 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026850
 protein coding gene Chr4:142061535-142065493 (+)
CAST/EiJ MGP_CASTEiJ_G0028289
 protein coding gene Chr4:151695010-151698630 (+)
CBA/J MGP_CBAJ_G0028838
 protein coding gene Chr4:166669125-166672727 (+)
DBA/2J MGP_DBA2J_G0028987
 protein coding gene Chr4:149761517-149765119 (+)
FVB/NJ MGP_FVBNJ_G0028951
 protein coding gene Chr4:148921695-148925297 (+)
LP/J MGP_LPJ_G0029077
 protein coding gene Chr4:156178189-156181791 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028978
 protein coding gene Chr4:169711007-169714609 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029636
 protein coding gene Chr4:154319997-154323599 (+)
PWK/PhJ MGP_PWKPhJ_G0028009
 protein coding gene Chr4:145834668-145838286 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027843
 protein coding gene Chr4:148600497-148604111 (+)
WSB/EiJ MGP_WSBEiJ_G0028369
 protein coding gene Chr4:154498454-154502055 (+)



Homology
more
  • Human Ortholog
    HES2, hes family bHLH transcription factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HES2, hes family bHLH transcription factor 2
  • Synonyms
    bHLHb40
  • Links
    NCBI Gene ID: 54626
    neXtProt AC: NX_Q9Y543
    UniProt: Q9Y543

  • Chr Location
    1p36.31; chr1:6412418-6424670 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    970
  • Tissues
    159
  • cDNA Data
    10
  • Literature Summary
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 15206 NCBI Gene Model | MGI Sequence Detail 3603 C57BL/6J ±  kb
transcript NM_001301805 RefSeq | MGI Sequence Detail 2915 ZRU/MplStud  
polypeptide O54792 UniProt | EBI | MGI Sequence Detail 157 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 2
    cDNA 12
    Primer pair 3
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 50
    Developmental Gene Expression 11
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:43727 Ishibashi M, et al., Molecular characterization of HES-2, a mammalian helix-loop-helix factor structurally related to Drosophila hairy and Enhancer of split. Eur J Biochem. 1993 Aug 1;215(3):645-52
  • Latest
    J:321979 Kurz J, et al., Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter. Development. 2022 Feb 15;149(4):dev199735
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory