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Brs3 Gene Detail
Summary
  • Symbol
    Brs3
  • Name
    bombesin-like receptor 3
  • Synonyms
    BRS-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100501
    NCBI Gene: 12209
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:56088434-56094118 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 30.78 cM, cytoband A7.1-A7.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100501
 protein coding gene ChrX:56088434-56094118 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035743
 protein coding gene ChrX:52360275-52365959 (+)
A/J MGP_AJ_G0035726
 protein coding gene ChrX:52553657-52559341 (+)
AKR/J MGP_AKRJ_G0035646
 protein coding gene ChrX:53952078-53957769 (+)
BALB/cJ MGP_BALBcJ_G0035713
 protein coding gene ChrX:52009450-52015134 (+)
C3H/HeJ MGP_C3HHeJ_G0035415
 protein coding gene ChrX:52887304-52892988 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036242
 protein coding gene ChrX:53744493-53750177 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033093
 protein coding gene ChrX:51966274-51972017 (+)
CAST/EiJ MGP_CASTEiJ_G0034708
 protein coding gene ChrX:38787823-38793519 (+)
CBA/J MGP_CBAJ_G0035390
 protein coding gene ChrX:55321308-55326992 (+)
DBA/2J MGP_DBA2J_G0035544
 protein coding gene ChrX:52135945-52141629 (+)
FVB/NJ MGP_FVBNJ_G0035494
 protein coding gene ChrX:51733609-51739337 (+)
LP/J MGP_LPJ_G0035632
 protein coding gene ChrX:52944457-52950141 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035530
 protein coding gene ChrX:56858451-56864142 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036258
 protein coding gene ChrX:52391365-52397049 (+)
PWK/PhJ MGP_PWKPhJ_G0034404
 protein coding gene ChrX:37057127-37062837 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034248
 protein coding gene ChrX:39519788-39525472 (+)
WSB/EiJ MGP_WSBEiJ_G0034851
 protein coding gene ChrX:51921532-51927217 (+)



Homology
more
  • Human Ortholog
    BRS3, bombesin receptor subtype 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BRS3, bombesin receptor subtype 3
  • Synonyms
    BB3, BB3R, BBR3
  • Links
    NCBI Gene ID: 680
    neXtProt AC: NX_P32247
    UniProt: P32247

  • Chr Location
    Xq26.3; chrX:136487947-136493780 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit mild obesity, hypertension, impaired glucose metabolism, reduced metabolic rate, and hyperphagia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    16
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12209 NCBI Gene Model | MGI Sequence Detail 5685 C57BL/6J ±  kb
    transcript NM_009766 RefSeq | MGI Sequence Detail 2772 C57BL/6  
    polypeptide O54798 UniProt | EBI | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 4
      cDNA 8
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 26
    • Earliest
      J:41803 Ohki-Hamazaki H, et al., Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse. Brain Res. 1997 Jul 11;762(1-2):165-72
    • Latest
      J:331457 Pauli JL, et al., Molecular and anatomical characterization of parabrachial neurons and their axonal projections. Elife. 2022 Nov 1;11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory