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Csnk2a2 Gene Detail
Summary
  • Symbol
    Csnk2a2
  • Name
    casein kinase 2, alpha prime polypeptide
  • Synonyms
    1110035J23Rik, CK2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88547
    NCBI Gene: 13000
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:96172724-96215505 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 47.12 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    915 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88547
 protein coding gene Chr8:96172724-96216667 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033987
 protein coding gene Chr8:96925569-96969262 (-)
A/J MGP_AJ_G0033970
 protein coding gene Chr8:93132011-93174776 (-)
AKR/J MGP_AKRJ_G0033896
 protein coding gene Chr8:95667457-95710295 (-)
BALB/cJ MGP_BALBcJ_G0033962
 protein coding gene Chr8:93216670-93259279 (-)
C3H/HeJ MGP_C3HHeJ_G0033672
 protein coding gene Chr8:96394902-96441360 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034483
 protein coding gene Chr8:100461858-100506529 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031424
 protein coding gene Chr8:86934405-86976608 (-)
CAST/EiJ MGP_CASTEiJ_G0033004
 protein coding gene Chr8:95986123-96030271 (-)
CBA/J MGP_CBAJ_G0033648
 protein coding gene Chr8:103743800-103787674 (-)
DBA/2J MGP_DBA2J_G0033802
 protein coding gene Chr8:92621558-92664223 (-)
FVB/NJ MGP_FVBNJ_G0033749
 protein coding gene Chr8:91572914-91615648 (-)
LP/J MGP_LPJ_G0033894
 protein coding gene Chr8:97060550-97103272 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033791
 protein coding gene Chr8:105996075-106039141 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034501
 protein coding gene Chr8:95844667-95887430 (-)
PWK/PhJ MGP_PWKPhJ_G0032706
 protein coding gene Chr8:91979783-92023098 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032543
 protein coding gene Chr8:94699498-94743452 (-)
WSB/EiJ MGP_WSBEiJ_G0033116
 protein coding gene Chr8:96361483-96404905 (-)



Homology
more
  • Human Ortholog
    CSNK2A2, casein kinase 2 alpha 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSNK2A2, casein kinase 2 alpha 2
  • Synonyms
    CK2A2, CK2alpha', CSNK2A1
  • Links
    NCBI Gene ID: 1459
    neXtProt AC: NX_P19784
    UniProt: P19784

  • Chr Location
    16q21; chr16:58157907-58198106 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Csnk2a2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males homozygotes for a targeted null mutation of the minor catalytic subunit exhibit infertility with oligospermia and abnormally shaped spermatid nuclei.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    863
  • Tissues
    143
  • cDNA Data
    21
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13000 NCBI Gene Model | MGI Sequence Detail 42782 C57BL/6J ±  kb
    transcript NM_009974 RefSeq | MGI Sequence Detail 3766 ZRU/MplStud  
    polypeptide O54833 UniProt | EBI | MGI Sequence Detail 350 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 1
      cDNA 23
      Primer pair 5
      Other 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-2205, MGI:1915939, MGI:2142847
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 18
      Phenotypes 18
    • Earliest
      J:2617 Yang-Feng TL, et al., Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit. Nucleic Acids Res. 1991 Dec;19(25):7125-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory