Eomes MGI Mouse Gene Detail - MGI:1201683

Symbol

Eomes
Name

eomesodermin
Synonyms

Tbr2

Feature Type

protein coding gene
IDs

MGI:1201683
NCBI Gene: 13813
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr9:118307259-118315176 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 70.21 cM, cytoband F3
Mapping Data

6 experiments

SNPs within 2kb

213 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1201683	protein coding gene	Chr9:118307259-118315200 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035405	protein coding gene	Chr9:121157863-121165779 (+)
A/J	MGP_AJ_G0035385	protein coding gene	Chr9:116682120-116690043 (+)
AKR/J	MGP_AKRJ_G0035318	protein coding gene	Chr9:119693419-119701332 (+)
BALB/cJ	MGP_BALBcJ_G0035381	protein coding gene	Chr9:116546916-116554838 (+)
C3H/HeJ	MGP_C3HHeJ_G0035089	protein coding gene	Chr9:120173642-120181565 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035904	protein coding gene	Chr9:124468157-124476074 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032787	protein coding gene	Chr9:113888127-113896129 (+)
CAST/EiJ	MGP_CASTEiJ_G0034393	protein coding gene	Chr9:120123868-120131792 (+)
CBA/J	MGP_CBAJ_G0035056	protein coding gene	Chr9:129144606-129152526 (+)
DBA/2J	MGP_DBA2J_G0035215	protein coding gene	Chr9:116126565-116134505 (+)
FVB/NJ	MGP_FVBNJ_G0035162	protein coding gene	Chr9:114962179-114970102 (+)
LP/J	MGP_LPJ_G0035294	protein coding gene	Chr9:121505788-121513701 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035203	protein coding gene	Chr9:130189837-130197760 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035923	protein coding gene	Chr9:120078775-120086692 (+)
PWK/PhJ	MGP_PWKPhJ_G0034100	protein coding gene	Chr9:116505943-116514290 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033934	protein coding gene	Chr9:120165822-120173708 (+)
WSB/EiJ	MGP_WSBEiJ_G0034514	protein coding gene	Chr9:119976130-119984041 (+)

Human Ortholog

EOMES, eomesodermin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EOMES, eomesodermin
Synonyms

TBR2
Links

HGNC:3372

NCBI Gene ID: 8320

neXtProt AC: NX_O95936

UniProt: O95936
Chr Location

3p24.1; chr3:27715949-27722713 (-) GRCh38

MGI Vertebrate Homology

Eomes stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: EOMES
Gene Tree

Eomes

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Phenotype Summary

49 phenotypes from 11 alleles in 12 genetic backgrounds
37 phenotypes from multigenic genotypes
1 images
145 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Endonuclease-mediated

9
Targeted

24
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice display embryonic lethality, fail to implant, and lack trophoectoderm outgrowth.

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All GO Annotations

64
GO References

29

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

2132
Tissues

336
cDNA Data

45
Literature Summary

959

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA EOMES

Xenbase eomes

ZFIN eomesa, eomesb

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All Sequences

51
RefSeq

6
UniProt

3
CCDS

CCDS23603.1, CCDS52960.1

Ensembl

ENSMUSG00000032446 (Evidence)
NCBI Gene

13813

			Length	Strain/Species	Flank
genomic	13813	NCBI Gene Model \| MGI Sequence Detail	7918	C57BL/6J	± kb
transcript	NM_010136	RefSeq \| MGI Sequence Detail	3689	ZRU/MplStud
polypeptide	O54839	UniProt \| EBI \| MGI Sequence Detail	707	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003463 eomesodermin

(term hierarchy)
InterPro Domains

IPR008967 p53-like transcription factor, DNA-binding domain superfamily

IPR036960 T-box superfamily

IPR001699 T-box transcription factor

IPR032385 T-box transcription factor-associated

IPR046360 T-box transcription factor, DNA-binding domain

IPR018186 Transcription factor, T-box, conserved site

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All nucleic 91

Genomic 2

cDNA 49

Primer pair 23

Other 17

Microarray probesets 5

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MGI:1313283, MGI:2143384

Summaries

All 1154

Developmental Gene Expression 959

Gene Ontology 29

Phenotypes 145
Earliest

J:46272 Wattler S, et al., A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family. Genomics. 1998 Feb 15;48(1):24-33
Latest

J:354454 De Vincenti AP, et al., Lrig1 regulates cell fate specification of glutamatergic neurons via FGF-driven Jak2/Stat3 signaling in cortical progenitors. Development. 2024 Sep 1;151(17):dev202879

TSS for Eomes:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87627	Chr9:118307250-118307267 (+)	0 bp
Tssr87628	Chr9:118307515-118307519 (+)	258 bp
Tssr87629	Chr9:118307692-118307703 (+)	439 bp
Tssr87630	Chr9:118307883-118307892 (+)	629 bp
Tssr87631	Chr9:118307919-118307934 (+)	668 bp
Tssr87632	Chr9:118309646-118309659 (+)	2,394 bp
Tssr87633	Chr9:118310333-118310355 (+)	3,085 bp
Tssr87634	Chr9:118314213-118314238 (+)	6,967 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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