E2f6 MGI Mouse Gene Detail - MGI:1354159 - E2F transcription factor 6

Symbol

E2f6
Name

E2F transcription factor 6
Synonyms

EMA

Feature Type

protein coding gene
IDs

MGI:1354159
NCBI Gene: 50496
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:16860932-16876753 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 8.04 cM
Mapping Data

2 experiments

SNPs within 2kb

475 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354159	protein coding gene	Chr12:16860932-16889743 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019612	protein coding gene	Chr12:14213656-14231015 (+)
A/J	MGP_AJ_G0019579	protein coding gene	Chr12:13715505-13732683 (+)
AKR/J	MGP_AKRJ_G0019549	protein coding gene	Chr12:14367409-14383200 (+)
BALB/cJ	MGP_BALBcJ_G0019555	protein coding gene	Chr12:13961002-13978216 (+)
C3H/HeJ	MGP_C3HHeJ_G0019360	protein coding gene	Chr12:14276404-14291776 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020003	protein coding gene	Chr12:14680208-14696003 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017629	protein coding gene	Chr12:13212388-13221913 (+)
CAST/EiJ	MGP_CASTEiJ_G0018915	protein coding gene	Chr12:14157741-14175838 (+)
CBA/J	MGP_CBAJ_G0019331	protein coding gene	Chr12:15492468-15509363 (+)
DBA/2J	MGP_DBA2J_G0019444	protein coding gene	Chr12:13632051-13647848 (+)
FVB/NJ	MGP_FVBNJ_G0019435	protein coding gene	Chr12:13518419-13534199 (+)
LP/J	MGP_LPJ_G0019515	protein coding gene	Chr12:14333552-14349300 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019470	protein coding gene	Chr12:15378875-15395899 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020042	protein coding gene	Chr12:14056057-14071900 (+)
PWK/PhJ	MGP_PWKPhJ_G0018681	protein coding gene	Chr12:13667257-13683246 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018471	protein coding gene	Chr12:14263751-14279673 (+)
WSB/EiJ	MGP_WSBEiJ_G0018966	protein coding gene	Chr12:14170487-14186307 (+)

Human Ortholog

E2F6, E2F transcription factor 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

E2F6, E2F transcription factor 6
Synonyms

E2F-6
Links

HGNC:3120

NCBI Gene ID: 1876

neXtProt AC: NX_O75461

UniProt: O75461
Chr Location

2p25.1; chr2:11444375-11466177 (-) GRCh38

MGI Vertebrate Homology

E2f6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: E2F6
Gene Tree

E2f6

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Phenotype Summary

8 phenotypes from 3 alleles in 2 genetic backgrounds
18 phenotypes from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Both homozygous and heterozygous null mice exhibit subtle posterior transformations of the axial skeleton with incomplete penetrance. In addition to skeletal transformations, male mice homozygous for one knock-out allele display defective spermatocyte development and Leydig cell hyperplasia.

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

991
Tissues

233
cDNA Data

67
Literature Summary

21

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase e2f6

ZFIN e2f6

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All Sequences

69
RefSeq

11
UniProt

7
CCDS

CCDS36409.1

Ensembl

ENSMUSG00000057469 (Evidence)
NCBI Gene

50496

			Length	Strain/Species	Flank
genomic	50496	NCBI Gene Model \| MGI Sequence Detail	15822	C57BL/6J	± kb
transcript	NR_027677	RefSeq \| MGI Sequence Detail	2512	ZRU/MplStud
polypeptide	O54917	UniProt \| EBI \| MGI Sequence Detail	272	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000006857 transcription factor E2F6

(term hierarchy)
InterPro Domains

IPR003316 E2F/DP family, winged-helix DNA-binding domain

IPR037241 E2F-DP heterodimerization region

IPR015633 E2F Family

IPR032198 E2F transcription factor, CC-MB domain

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 77

cDNA 67

Primer pair 8

Other 2

Microarray probesets 4

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MGI:2144836

Summaries

All 63

Developmental Gene Expression 21

Gene Ontology 8

Phenotypes 9
Earliest

J:44763 Morkel M, et al., An E2F-like repressor of transcription [letter]. Nature. 1997 Dec 11;390(6660):567-8
Latest

J:332407 Gu Y, et al., Multi-omics profiling visualizes dynamics of cardiac development and functions. Cell Rep. 2022 Dec 27;41(13):111891

TSS for E2f6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112858	Chr12:16860941-16860979 (+)	28 bp
Tssr112859	Chr12:16860980-16860991 (+)	54 bp
Tssr112860	Chr12:16862392-16862396 (+)	1,462 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24