Dnajb6 MGI Mouse Gene Detail - MGI:1344381 - DnaJ heat shock protein family (Hsp40) member B6

Symbol

Dnajb6
Name

DnaJ heat shock protein family (Hsp40) member B6
Synonyms

mDj4, Mrj

Feature Type

protein coding gene
IDs

MGI:1344381
NCBI Gene: 23950
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr5:29940896-29991476 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 15.27 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

1246 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344381	protein coding gene	Chr5:29940686-30023132 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029379	protein coding gene	Chr5:27684190-27783385 (+)
A/J	MGP_AJ_G0029345	protein coding gene	Chr5:26758535-26845601 (+)
AKR/J	MGP_AKRJ_G0029296	protein coding gene	Chr5:27838457-27932217 (+)
BALB/cJ	MGP_BALBcJ_G0029356	protein coding gene	Chr5:27288446-27375107 (+)
C3H/HeJ	MGP_C3HHeJ_G0029077	protein coding gene	Chr5:27861610-27952465 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029809	protein coding gene	Chr5:29349334-29449422 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027047	protein coding gene	Chr5:24313541-24391936 (+)
CAST/EiJ	MGP_CASTEiJ_G0028488	protein coding gene	Chr5:26969748-27063793 (+)
CBA/J	MGP_CBAJ_G0029045	protein coding gene	Chr5:29903948-30010978 (+)
DBA/2J	MGP_DBA2J_G0029194	protein coding gene	Chr5:26954632-27046648 (+)
FVB/NJ	MGP_FVBNJ_G0029152	protein coding gene	Chr5:26364463-26452566 (+)
LP/J	MGP_LPJ_G0029279	protein coding gene	Chr5:28119889-28206663 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029181	protein coding gene	Chr5:30881623-30978344 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029843	protein coding gene	Chr5:27418699-27511525 (+)
PWK/PhJ	MGP_PWKPhJ_G0028212	protein coding gene	Chr5:26071750-26157861 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028043	protein coding gene	Chr5:26720262-26814351 (+)
WSB/EiJ	MGP_WSBEiJ_G0028568	protein coding gene	Chr5:27469430-27556317 (+)

Human Ortholog

DNAJB6, DnaJ heat shock protein family (Hsp40) member B6

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJB6, DnaJ heat shock protein family (Hsp40) member B6
Synonyms

DJ4, DnaJ, HHDJ1, HSJ-2, HSJ2, LGMD1D, LGMD1E, LGMDD1, MRJ, MSJ-1
Links

HGNC:14888

NCBI Gene ID: 10049

neXtProt AC: NX_O75190

UniProt: O75190
Chr Location

7q36.3; chr7:157335381-157417439 (+) GRCh38

MGI Vertebrate Homology

Dnajb6 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DNAJB6
Gene Tree

Dnajb6

Diseases

1 with human DNAJB6 associations

				Human Disease	Mouse Models
				autosomal dominant limb-girdle muscular dystrophy type 1 IDs autosomal dominant limb-girdle muscular dystrophy type 1 DOID:0110305 ICD10CM:G71.0 OMIM:603511 ORDO:34517

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
40 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

116
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

105
Radiation induced

3
Spontaneous

1
Targeted

3
Genomic Mutations

6 involving Dnajb6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

73 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants died at mid-gestation due to a failure of chorioallantoic fusion at embryonic day 8.5, and thus preventing the formation of a mature placenta.

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All GO Annotations

52
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

849
Tissues

49
cDNA Data

219
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajb6

ZFIN dnajb6b

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All Sequences

95
RefSeq

13
UniProt

7
CCDS

CCDS19151.1, CCDS19152.1, CCDS39043.1

Ensembl

ENSMUSG00000029131 (Evidence)
NCBI Gene

23950

			Length	Strain/Species	Flank
genomic	23950	NCBI Gene Model \| MGI Sequence Detail	50581	C57BL/6J	± kb
transcript	NM_001037940	RefSeq \| MGI Sequence Detail	2708	C57BL/6
polypeptide	O54946	UniProt \| EBI \| MGI Sequence Detail	365	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000006576 DnaJ homolog subfamily B member 6

(term hierarchy)
InterPro Domains

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR018253 DnaJ domain, conserved site

IPR043183 DnaJ homolog subfamily B member 2/6-like

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All nucleic 220

Genomic 1

cDNA 219

Microarray probesets 12

Summaries

All 74

Developmental Gene Expression 7

Diseases 1

Gene Ontology 12

Phenotypes 40
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:331268 Ding Y, et al., A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. Elife. 2022 Oct 18;11

TSS for Dnajb6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45546	Chr5:29940723-29940735 (+)	-167 bp
Tssr45547	Chr5:29940737-29940749 (+)	-153 bp
Tssr45548	Chr5:29940820-29940829 (+)	-71 bp
Tssr45549	Chr5:29940835-29940848 (+)	-54 bp
Tssr45550	Chr5:29940965-29940987 (+)	80 bp
Tssr45551	Chr5:29940989-29941009 (+)	103 bp
Tssr45552	Chr5:29941110-29941138 (+)	228 bp
Tssr45553	Chr5:29941449-29941458 (+)	558 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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