Banf1 MGI Mouse Gene Detail - MGI:1346330 - BAF nuclear assembly factor 1

Symbol

Banf1
Name

BAF nuclear assembly factor 1
Synonyms

barrier to autointegration factor 1, Bcrp1, C78287

Feature Type

protein coding gene
IDs

MGI:1346330
NCBI Gene: 23825
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr19:5414661-5416904 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.31 cM, cytoband A
Mapping Data

3 experiments

SNPs within 2kb

108 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346330	protein coding gene	Chr19:5414661-5417196 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024700	protein coding gene	Chr19:2322112-2324115 (-)
A/J	MGP_AJ_G0024666	protein coding gene	Chr19:2197841-2199861 (-)
AKR/J	MGP_AKRJ_G0024639	protein coding gene	Chr19:2259737-2261735 (-)
BALB/cJ	MGP_BALBcJ_G0024666	protein coding gene	Chr19:2193957-2195956 (-)
C3H/HeJ	MGP_C3HHeJ_G0024434	protein coding gene	Chr19:2265484-2267488 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025113	protein coding gene	Chr19:2381883-2383881 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022543	protein coding gene	Chr19:2104329-2106168 (-)
CAST/EiJ	MGP_CASTEiJ_G0023906	protein coding gene	Chr19:2293345-2295348 (-)
CBA/J	MGP_CBAJ_G0024406	protein coding gene	Chr19:2483509-2485517 (-)
DBA/2J	MGP_DBA2J_G0024533	protein coding gene	Chr19:2176970-2178970 (-)
FVB/NJ	MGP_FVBNJ_G0024500	protein coding gene	Chr19:2185207-2187233 (-)
LP/J	MGP_LPJ_G0024619	protein coding gene	Chr19:2305237-2307242 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024530	protein coding gene	Chr19:2339541-2341336 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025161	protein coding gene	Chr19:2260819-2262817 (-)
PWK/PhJ	MGP_PWKPhJ_G0023652	protein coding gene	Chr19:2215368-2217428 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023457	protein coding gene	Chr19:2250768-2252985 (-)
WSB/EiJ	MGP_WSBEiJ_G0023968	protein coding gene	Chr19:2278139-2280144 (-)

Human Ortholog

BANF1, barrier to autointegration nuclear assembly factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BANF1, barrier to autointegration nuclear assembly factor 1
Synonyms

BAF, BCRP1, D14S1460, NGPS
Links

HGNC:17397

NCBI Gene ID: 8815

neXtProt AC: NX_O75531

UniProt: O75531
Chr Location

11q13.1; chr11:66002079-66004149 (+) GRCh38

MGI Vertebrate Homology

Banf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BANF1
Gene Tree

Banf1

Diseases

1 with human BANF1 associations

				Human Disease	Mouse Models
				Nestor-Guillermo progeria syndrome IDs Nestor-Guillermo progeria syndrome DOID:0081334 OMIM:614008 ORDO:280576

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
1 images
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

78
Endonuclease-mediated

2
Gene trapped

72
Targeted

4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture.

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All GO Annotations

43
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

105

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase banf1

ZFIN banf1

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All Sequences

52
RefSeq

7
UniProt

1
CCDS

CCDS29458.1

Ensembl

ENSMUSG00000024844 (Evidence)
NCBI Gene

23825

			Length	Strain/Species	Flank
genomic	23825	NCBI Gene Model \| MGI Sequence Detail	2244	C57BL/6J	± kb
transcript	NM_001286608	RefSeq \| MGI Sequence Detail	1108	C57BL/6
polypeptide	O54962	UniProt \| EBI \| MGI Sequence Detail	89	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004637 barrier-to-autointegration factor

(term hierarchy)
InterPro Domains

IPR051387 Barrier-to-autointegration factor

IPR004122 Barrier- to-autointegration factor, BAF

IPR036617 Barrier-to-autointegration factor, BAF superfamily

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All nucleic 106

cDNA 106

Microarray probesets 5

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MGI:2147785

Summaries

All 47

Gene Ontology 8

Phenotypes 13
Earliest

J:57554 Lee MS, et al., A previously unidentified host protein protects retroviral DNA from autointegration. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1528-33
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Banf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157579	Chr19:5416654-5416691 (-)	231 bp
Tssr157578	Chr19:5416626-5416639 (-)	271 bp
Tssr157577	Chr19:5416313-5416406 (-)	544 bp
Tssr157576	Chr19:5416297-5416308 (-)	601 bp
Tssr157575	Chr19:5416281-5416292 (-)	617 bp
Tssr157574	Chr19:5414921-5414946 (-)	1,970 bp
Tssr157573	Chr19:5414887-5414906 (-)	2,007 bp
Tssr157572	Chr19:5414830-5414853 (-)	2,062 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24