Rad51d MGI Mouse Gene Detail - MGI:1261809

Symbol

Rad51d
Name

RAD51 paralog D
Synonyms

R51H3, Rad51l3

Feature Type

protein coding gene
IDs

MGI:1261809
NCBI Gene: 19364
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:82767260-82781440 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 50.30 cM
Mapping Data

5 experiments

SNPs within 2kb

557 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1261809	protein coding gene	Chr11:82762786-82781571 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018832	protein coding gene	Chr11:84158391-84173490 (-)
A/J	MGP_AJ_G0018799	protein coding gene	Chr11:80925569-80939454 (-)
AKR/J	MGP_AKRJ_G0018769	protein coding gene	Chr11:83350935-83366208 (-)
BALB/cJ	MGP_BALBcJ_G0018772	protein coding gene	Chr11:81326782-81343372 (-)
C3H/HeJ	MGP_C3HHeJ_G0018586	protein coding gene	Chr11:83387057-83401259 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019224	protein coding gene	Chr11:86678085-86695065 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016858	protein coding gene	Chr11:77888399-77903272 (-)
CAST/EiJ	MGP_CASTEiJ_G0018141	protein coding gene	Chr11:83972822-83989573 (-)
CBA/J	MGP_CBAJ_G0018557	protein coding gene	Chr11:90431159-90450049 (-)
DBA/2J	MGP_DBA2J_G0018665	protein coding gene	Chr11:80499855-80514543 (-)
FVB/NJ	MGP_FVBNJ_G0018654	protein coding gene	Chr11:80025582-80039819 (-)
LP/J	MGP_LPJ_G0018735	protein coding gene	Chr11:84671965-84688513 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018681	protein coding gene	Chr11:90631276-90647123 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019264	protein coding gene	Chr11:83613425-83628772 (-)
PWK/PhJ	MGP_PWKPhJ_G0017911	protein coding gene	Chr11:81320430-81335799 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017702	protein coding gene	Chr11:83237125-83251819 (-)
WSB/EiJ	MGP_WSBEiJ_G0018193	protein coding gene	Chr11:83500326-83514958 (-)

Human Ortholog

RAD51D, RAD51 paralog D

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAD51D, RAD51 paralog D
Synonyms

BROVCA4, R51H3, RAD51L3, TRAD
Links

HGNC:9823

NCBI Gene ID: 5892

neXtProt AC: NX_O75771

UniProt: O75771
Chr Location

17q12; chr17:35092221-35121522 (-) GRCh38

MGI Vertebrate Homology

Rad51d stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAD51D
Protein SuperFamily

Rad51
Gene Tree

Rad51d

Diseases

1 with human RAD51D associations

				Human Disease	Mouse Models
				hereditary breast ovarian cancer syndrome IDs hereditary breast ovarian cancer syndrome DOID:5683 MESH:D061325 NCI:C8493 UMLS_CUI:C0677776

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
1 images
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

11
Targeted

4
Genomic Mutations

2 involving Rad51d
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene die as embryos before E11.5.

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All GO Annotations

56
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

12
cDNA Data

17
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rad51d

ZFIN rad51d

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All Sequences

92
RefSeq

16
UniProt

13
CCDS

CCDS36250.1, CCDS70267.1, CCDS70268.1

Ensembl

ENSMUSG00000018841 (Evidence)
NCBI Gene

19364

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018841	Ensembl Gene Model \| MGI Sequence Detail	14181	C57BL/6J	± kb
transcript	ENSMUST00000018985	Ensembl \| MGI Sequence Detail	3426	Not Applicable
polypeptide	ENSMUSP00000018985	Ensembl \| MGI Sequence Detail	329	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000013677 DNA repair protein RAD51 homolog 4

(term hierarchy)
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR013632 DNA recombination and repair protein Rad51-like, C-terminal

IPR016467 DNA recombination and repair protein, RecA-like

IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain

IPR047323 DNA repair protein RAD51 homolog 4, C-terminal

IPR051988 Homologous Recombination Repair RAD51 Paralog

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR048943 RAD51D, N-terminal domain

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All nucleic 20

cDNA 17

Primer pair 3

Microarray probesets 7

Summaries

All 51

Developmental Gene Expression 2

Gene Ontology 11

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:175085 Le Masson F, et al., Identification of Heat Shock Factor 1 Molecular and Cellular Targets during Embryonic and Adult Female Meiosis. Mol Cell Biol. 2011 Aug;31(16):3410-23

TSS for Rad51d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109593	Chr11:82781367-82781452 (-)	30 bp
Tssr109592	Chr11:82781327-82781360 (-)	96 bp
Tssr109591	Chr11:82780847-82780858 (-)	587 bp
Tssr109590	Chr11:82780812-82780827 (-)	620 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24