Pkig MGI Mouse Gene Detail - MGI:1343086 - protein kinase inhibitor, gamma

Symbol

Pkig
Name

protein kinase inhibitor, gamma
Synonyms

PKIgamma

Feature Type

protein coding gene
IDs

MGI:1343086
NCBI Gene: 18769
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr2:163500306-163568078 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 84.40 cM
Mapping Data

2 experiments

SNPs within 2kb

2105 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1343086	protein coding gene	Chr2:163500306-163568078 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026828	protein coding gene	Chr2:169014400-169088647 (+)
A/J	MGP_AJ_G0026794	protein coding gene	Chr2:162196970-162268710 (+)
AKR/J	MGP_AKRJ_G0026765	protein coding gene	Chr2:166997400-167067384 (+)
BALB/cJ	MGP_BALBcJ_G0026803	protein coding gene	Chr2:162528895-162607171 (+)
C3H/HeJ	MGP_C3HHeJ_G0026545	protein coding gene	Chr2:167350157-167417192 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027251	protein coding gene	Chr2:173943700-174017308 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024621	protein coding gene	Chr2:155499512-155570726 (+)
CAST/EiJ	MGP_CASTEiJ_G0026006	protein coding gene	Chr2:167743909-167821981 (+)
CBA/J	MGP_CBAJ_G0026522	protein coding gene	Chr2:180226831-180298871 (+)
DBA/2J	MGP_DBA2J_G0026660	protein coding gene	Chr2:161367478-161435136 (+)
FVB/NJ	MGP_FVBNJ_G0026626	protein coding gene	Chr2:159740572-159809138 (+)
LP/J	MGP_LPJ_G0026763	protein coding gene	Chr2:169137604-169207912 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026648	protein coding gene	Chr2:183882830-183960733 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027307	protein coding gene	Chr2:166892146-166965246 (+)
PWK/PhJ	MGP_PWKPhJ_G0025740	protein coding gene	Chr2:160930395-161003555 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025543	protein coding gene	Chr2:165763042-165837433 (+)
WSB/EiJ	MGP_WSBEiJ_G0026076	protein coding gene	Chr2:167741492-167814741 (+)

Human Ortholog

PKIG, cAMP-dependent protein kinase inhibitor gamma

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PKIG, cAMP-dependent protein kinase inhibitor gamma
Synonyms

PKI-gamma
Links

HGNC:9019

NCBI Gene ID: 11142

neXtProt AC: NX_Q9Y2B9

UniProt: Q9Y2B9
Chr Location

20q13.12; chr20:44531785-44624247 (+) GRCh38

MGI Vertebrate Homology

Pkig stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PKIG
Protein SuperFamily

PKI
Gene Tree

Pkig

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Endonuclease-mediated

1
Gene trapped

20
Targeted

4
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

20
cDNA Data

83
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pkig

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All Sequences

110
RefSeq

46
UniProt

5
CCDS

CCDS17014.1

Ensembl

ENSMUSG00000035268 (Evidence)
NCBI Gene

18769

			Length	Strain/Species	Flank
genomic	18769	NCBI Gene Model \| MGI Sequence Detail	67773	C57BL/6J	± kb
transcript	NM_001420675	RefSeq \| MGI Sequence Detail	2928	ZRU/MplStud
polypeptide	O70139	UniProt \| EBI \| MGI Sequence Detail	76	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012781 cAMP-dependent protein kinase inhibitor gamma

(term hierarchy)
InterPro Domains

IPR004171 cAMP-dependent protein kinase inhibitor

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All nucleic 86

cDNA 83

Primer pair 1

Other 2

Microarray probesets 5

Summaries

All 43

Developmental Gene Expression 5

Gene Ontology 3

Phenotypes 17
Earliest

J:41726 Collins SP, et al., Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase. J Biol Chem. 1997 Jul 18;272(29):18169-78
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pkig:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21482	Chr2:163500290-163500430 (+)	54 bp
Tssr21483	Chr2:163500435-163500446 (+)	135 bp
Tssr21484	Chr2:163500449-163500454 (+)	146 bp
Tssr21485	Chr2:163500517-163500528 (+)	217 bp
Tssr21486	Chr2:163501036-163501051 (+)	738 bp
Tssr21487	Chr2:163501054-163501087 (+)	765 bp
Tssr21488	Chr2:163501089-163501101 (+)	789 bp
Tssr21489	Chr2:163503415-163503418 (+)	3,111 bp
Tssr21490	Chr2:163504804-163504826 (+)	4,509 bp
Tssr21491	Chr2:163535935-163535978 (+)	35,651 bp
Tssr21492	Chr2:163563154-163563169 (+)	62,856 bp
Tssr21493	Chr2:163567590-163567613 (+)	67,296 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24