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Pdlim3 Gene Detail
Summary
  • Symbol
    Pdlim3
  • Name
    PDZ and LIM domain 3
  • Synonyms
    ALP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859274
    NCBI Gene: 53318
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:46338498-46372585 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 25.86 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1101 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859274
 protein coding gene Chr8:46338498-46372672 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033578
 protein coding gene Chr8:44956731-44994603 (+)
A/J MGP_AJ_G0033560
 protein coding gene Chr8:43230391-43267084 (+)
AKR/J MGP_AKRJ_G0033485
 protein coding gene Chr8:44489963-44529321 (+)
BALB/cJ MGP_BALBcJ_G0033557
 protein coding gene Chr8:43406424-43446383 (+)
C3H/HeJ MGP_C3HHeJ_G0033266
 protein coding gene Chr8:45020623-45055069 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034073
 protein coding gene Chr8:46662971-46700818 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031022
 protein coding gene Chr8:39507950-39539332 (+)
CAST/EiJ MGP_CASTEiJ_G0032592
 protein coding gene Chr8:44463901-44498134 (+)
CBA/J MGP_CBAJ_G0033245
 protein coding gene Chr8:48542986-48587194 (+)
DBA/2J MGP_DBA2J_G0033398
 protein coding gene Chr8:43036492-43070235 (+)
FVB/NJ MGP_FVBNJ_G0033339
 protein coding gene Chr8:42531040-42567491 (+)
LP/J MGP_LPJ_G0033486
 protein coding gene Chr8:44976469-45009768 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033384
 protein coding gene Chr8:48624998-48663883 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034091
 protein coding gene Chr8:44656011-44693855 (+)
PWK/PhJ MGP_PWKPhJ_G0032300
 protein coding gene Chr8:42565358-42598514 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032136
 protein coding gene Chr8:43812055-43848127 (+)
WSB/EiJ MGP_WSBEiJ_G0032708
 protein coding gene Chr8:44913901-44950649 (+)



Homology
more
  • Human Ortholog
    PDLIM3, PDZ and LIM domain 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDLIM3, PDZ and LIM domain 3
  • Synonyms
    ALP
  • Links
    NCBI Gene ID: 27295
    neXtProt AC: NX_Q53GG5
    UniProt: Q53GG5

  • Chr Location
    4q35.1; chr4:185500660-185535507 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pdlim3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a knock-out allele show no major defects in skeletal muscle. However, homozygotes for another knock-out allele show partial background-sensitive prenatal lethality, embryonic right ventricular (RV) dilation and dysplasia, hypotrabeculation, and RV cardiomyopathy in surviving adults.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    75
  • cDNA Data
    68
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031636 Ensembl Gene Model | MGI Sequence Detail 34088 C57BL/6J ±  kb
    transcript ENSMUST00000210422 Ensembl | MGI Sequence Detail 1479 Not Applicable  
    polypeptide ENSMUSP00000148113 Ensembl | MGI Sequence Detail 364 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 68
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142561
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:71343 Xia H, et al., Actinin-associated LIM protein: identification of a domain interaction between PDZ and spectrin-like repeat motifs. J Cell Biol. 1997 Oct 20;139(2):507-15
    • Latest
      J:329949 Yuan H, et al., A potential role of p75NTR in the regulation of circadian rhythm and incremental growth lines during tooth development. Front Physiol. 2022;13:981311
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory