Tpst1 MGI Mouse Gene Detail - MGI:1298231 - protein-tyrosine sulfotransferase 1

Symbol

Tpst1
Name

protein-tyrosine sulfotransferase 1
Synonyms

Tango13a

Feature Type

protein coding gene
IDs

MGI:1298231
NCBI Gene: 22021
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:130102167-130164570 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 68.53 cM, cytoband F-G1
Mapping Data

2 experiments

SNPs within 2kb

1887 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1298231	protein coding gene	Chr5:130102167-130164575 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030140	protein coding gene	Chr5:134186240-134249609 (+)
A/J	MGP_AJ_G0030108	protein coding gene	Chr5:128527853-128590273 (+)
AKR/J	MGP_AKRJ_G0030041	protein coding gene	Chr5:132700516-132762960 (+)
BALB/cJ	MGP_BALBcJ_G0030118	protein coding gene	Chr5:129880057-129942798 (+)
C3H/HeJ	MGP_C3HHeJ_G0029834	protein coding gene	Chr5:133266191-133329618 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030571	protein coding gene	Chr5:139332314-139396226 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027796	protein coding gene	Chr5:122909981-122972141 (+)
CAST/EiJ	MGP_CASTEiJ_G0029244	protein coding gene	Chr5:132579369-132647812 (+)
CBA/J	MGP_CBAJ_G0029804	protein coding gene	Chr5:144760607-144826131 (+)
DBA/2J	MGP_DBA2J_G0029955	protein coding gene	Chr5:128492902-128555432 (+)
FVB/NJ	MGP_FVBNJ_G0029910	protein coding gene	Chr5:127585323-127648056 (+)
LP/J	MGP_LPJ_G0030043	protein coding gene	Chr5:134697268-134761248 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029942	protein coding gene	Chr5:148095912-148159347 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030611	protein coding gene	Chr5:132400873-132463254 (+)
PWK/PhJ	MGP_PWKPhJ_G0028958	protein coding gene	Chr5:127433309-127495052 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028794	protein coding gene	Chr5:129968610-130030516 (+)
WSB/EiJ	MGP_WSBEiJ_G0029317	protein coding gene	Chr5:133106274-133169730 (+)

Human Ortholog

TPST1, tyrosylprotein sulfotransferase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TPST1, tyrosylprotein sulfotransferase 1
Synonyms

TANGO13A
Links

HGNC:12020

NCBI Gene ID: 8460

neXtProt AC: NX_O60507

UniProt: O60507
Chr Location

7q11.21; chr7:66198790-66420543 (+) GRCh38

MGI Vertebrate Homology

Tpst1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TPST1
Gene Tree

Tpst1

Diseases

1 with human TPST1 associations

				Human Disease	Mouse Models
				colorectal adenocarcinoma IDs colorectal adenocarcinoma DOID:0050861 NCI:C5105 UMLS_CUI:C1319315

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Gene trapped

11
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Tpst1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit reduced body weight but develop normally. Homozygous females produce smaller sized litters than control females.

less

All GO Annotations

17
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

66

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tpst1

less

All Sequences

52
RefSeq

10
UniProt

3
CCDS

CCDS39293.1

Ensembl

ENSMUSG00000034118 (Evidence)
NCBI Gene

22021

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034118	Ensembl Gene Model \| MGI Sequence Detail	62404	C57BL/6J	± kb
transcript	ENSMUST00000118993	Ensembl \| MGI Sequence Detail	1867	Not Applicable
polypeptide	ENSMUSP00000112571	Ensembl \| MGI Sequence Detail	370	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000016594 protein-tyrosine sulfotransferase 1

(term hierarchy)
EC

2.8.2.20
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR026634 Protein-tyrosine sulfotransferase-like
GlyGen

O70281 2 sites

less

All nucleic 67

Genomic 1

cDNA 66

Microarray probesets 3

less

MGI:2141351

Summaries

All 46

Gene Ontology 8

Phenotypes 20
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:338109 Dai D, et al., Enhanced tyrosine sulfation is associated with chronic kidney disease-related atherosclerosis. BMC Biol. 2023 Jul 10;21(1):151

TSS for Tpst1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49034	Chr5:130108232-130108244 (+)	6,071 bp
Tssr49035	Chr5:130108267-130108276 (+)	6,105 bp
Tssr49036	Chr5:130108280-130108289 (+)	6,118 bp
Tssr49037	Chr5:130108293-130108302 (+)	6,131 bp
Tssr49038	Chr5:130108319-130108333 (+)	6,159 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24