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Grpel2 Gene Detail
Summary
  • Symbol
    Grpel2
  • Name
    GrpE-like 2, mitochondrial
  • Synonyms
    mt-GrpE#2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334416
    NCBI Gene: 17714
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:61845495-61859396 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 34.69 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    495 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1334416
 protein coding gene Chr18:61845495-61860068 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024484
 protein coding gene Chr18:61615764-61629655 (-)
A/J MGP_AJ_G0024451
 protein coding gene Chr18:58969852-58983709 (-)
AKR/J MGP_AKRJ_G0024421
 protein coding gene Chr18:60591251-60605030 (-)
BALB/cJ MGP_BALBcJ_G0024450
 protein coding gene Chr18:59095942-59111390 (-)
C3H/HeJ MGP_C3HHeJ_G0024218
 protein coding gene Chr18:60825621-60839488 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024897
 protein coding gene Chr18:63286469-63300330 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022328
 protein coding gene Chr18:58514378-58527352 (-)
CAST/EiJ MGP_CASTEiJ_G0023691
 protein coding gene Chr18:60711051-60722646 (-)
CBA/J MGP_CBAJ_G0024188
 protein coding gene Chr18:65341440-65355297 (-)
DBA/2J MGP_DBA2J_G0024318
 protein coding gene Chr18:58639334-58653828 (-)
FVB/NJ MGP_FVBNJ_G0024284
 protein coding gene Chr18:58054181-58068070 (-)
LP/J MGP_LPJ_G0024401
 protein coding gene Chr18:61473655-61489181 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024313
 protein coding gene Chr18:66906198-66921018 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024944
 protein coding gene Chr18:60805230-60819120 (-)
PWK/PhJ MGP_PWKPhJ_G0023434
 protein coding gene Chr18:58870811-58885097 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023240
 protein coding gene Chr18:61027143-61041330 (-)
WSB/EiJ MGP_WSBEiJ_G0023755
 protein coding gene Chr18:60654714-60670335 (-)



Homology
more
  • Human Ortholog
    GRPEL2, GrpE like 2, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRPEL2, GrpE like 2, mitochondrial
  • Synonyms
    Mt-GrpE#2
  • Links
    NCBI Gene ID: 134266
    neXtProt AC: NX_Q8TAA5
    UniProt: Q8TAA5

  • Chr Location
    5q32; chr5:149345430-149354583 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    74
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024580 Ensembl Gene Model | MGI Sequence Detail 13902 C57BL/6J ±  kb
transcript ENSMUST00000062991 Ensembl | MGI Sequence Detail 4038 Not Applicable  
polypeptide ENSMUSP00000053440 Ensembl | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008273 GrpE protein homolog 2, mitochondrial
    (term hierarchy)
  • InterPro Domains
    IPR000740 GrpE nucleotide exchange factor
    IPR013805 GrpE nucleotide exchange factor, coiled-coil
    IPR009012 GrpE nucleotide exchange factor, head
  • GlyGen
    O88396 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 74
    cDNA 74

    Microarray probesets 4
References
more
  • Summaries
    All 33
    Gene Ontology 8
    Phenotypes 5
  • Earliest
    J:49134 Naylor DJ, et al., Evidence for the existence of distinct mammalian cytosolic, microsomal, and two mitochondrial GrpE-like proteins, the Co-chaperones of specific Hsp70 members. J Biol Chem. 1998 Aug 14;273(33):21169-77
  • Latest
    J:344841 Yang R, et al., Grpel2 maintains cardiomyocyte survival in diabetic cardiomyopathy through DLST-mediated mitochondrial dysfunction: a proof-of-concept study. J Transl Med. 2023 Mar 16;21(1):200
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory