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Ikbkg Gene Detail
Summary
  • Symbol
    Ikbkg
  • Name
    inhibitor of kappaB kinase gamma
  • Synonyms
    1110037D23Rik, IKK[g], NEMO
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338074
    NCBI Gene: 16151
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:73436896-73497460 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 38.00 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    873 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338074
 protein coding gene ChrX:73436883-73498013 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035847
 protein coding gene ChrX:70201509-70262158 (+)
A/J MGP_AJ_G0035828
 protein coding gene ChrX:70381258-70444769 (+)
AKR/J MGP_AKRJ_G0035753
 protein coding gene ChrX:72279655-72345455 (+)
BALB/cJ MGP_BALBcJ_G0035813
 protein coding gene ChrX:69406513-69465759 (+)
C3H/HeJ MGP_C3HHeJ_G0035518
 protein coding gene ChrX:70672992-70733260 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036343
 protein coding gene ChrX:72366518-72447983 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033187
 protein coding gene ChrX:69444220-69510507 (+)
CAST/EiJ MGP_CASTEiJ_G0034809
 protein coding gene ChrX:56050205-56112562 (+)
CBA/J MGP_CBAJ_G0035493
 protein coding gene ChrX:74365662-74431394 (+)
DBA/2J MGP_DBA2J_G0035650
 protein coding gene ChrX:69844170-69903114 (+)
FVB/NJ MGP_FVBNJ_G0035594
 protein coding gene ChrX:69184896-69246687 (+)
LP/J MGP_LPJ_G0035735
 protein coding gene ChrX:70971508-71033656 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035632
 protein coding gene ChrX:76917937-76978905 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036365
 protein coding gene ChrX:70014946-70077209 (+)
PWK/PhJ MGP_PWKPhJ_G0034508
 protein coding gene ChrX:54013228-54071430 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034342
 protein coding gene ChrX:56922752-56986698 (+)
WSB/EiJ MGP_WSBEiJ_G0034950
 protein coding gene ChrX:69299569-69359696 (+)



Homology
more
  • Human Ortholog
    IKBKG, inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IKBKG, inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  • Synonyms
    AMCBX1, EDAID1, FIP-3, FIP3, Fip3p, IKKAP1, IKKG, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, SAIDX, ZC2HC9
  • Links
    NCBI Gene ID: 8517
    neXtProt AC: NX_Q9Y6K9
    UniProt: Q9Y6K9

  • Chr Location
    Xq28; chrX:154541199-154565046 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ikbkg mouse models; 6 with human IKBKG associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    94 phenotypes from 8 alleles in 13 genetic backgrounds
    35 phenotypes from multigenic genotypes
    6 images
    90 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males hemizygous for targeted null mutations exhibit embryonic lethality by embryonic day 13.5 from apoptotic liver damage. Heterozygous females show patchy skin lesions with granulocyte infiltration, growth retardation, and shortened lifespan.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    24
  • cDNA Data
    108
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004221 Ensembl Gene Model | MGI Sequence Detail 60565 C57BL/6J ±  kb
    transcript ENSMUST00000004330 Ensembl | MGI Sequence Detail 6918 Not Applicable  
    polypeptide ENSMUSP00000004330 Ensembl | MGI Sequence Detail 430 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 109
      Primer pair 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:1923574, MGI:2147920, MGI:2147925, MGI:2148001
    References
    more
    • Summaries
      All 219
      Developmental Gene Expression 7
      Diseases 3
      Gene Ontology 31
      Phenotypes 90
    • Earliest
      J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
    • Latest
      J:338216 Vucur M, et al., Sublethal necroptosis signaling promotes inflammation and liver cancer. Immunity. 2023 Jul 11;56(7):1578-1595.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory