Zfr MGI Mouse Gene Detail - MGI:1341890 - zinc finger RNA binding protein

Symbol

Zfr
Name

zinc finger RNA binding protein
Synonyms

C920030H05Rik

Feature Type

protein coding gene
IDs

MGI:1341890
NCBI Gene: 22763
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr15:12117917-12185769 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 5.90 cM, cytoband A
Mapping Data

3 experiments

SNPs within 2kb

1479 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341890	protein coding gene	Chr15:12117649-12185769 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021734	protein coding gene	Chr15:9339489-9409158 (+)
A/J	MGP_AJ_G0021694	protein coding gene	Chr15:9043953-9114015 (+)
AKR/J	MGP_AKRJ_G0021672	protein coding gene	Chr15:9290720-9362132 (+)
BALB/cJ	MGP_BALBcJ_G0021701	protein coding gene	Chr15:8954492-9024302 (+)
C3H/HeJ	MGP_C3HHeJ_G0021477	protein coding gene	Chr15:9244965-9319221 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022140	protein coding gene	Chr15:9684262-9760540 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019681	protein coding gene	Chr15:8579141-8644600 (+)
CAST/EiJ	MGP_CASTEiJ_G0020993	protein coding gene	Chr15:9334789-9409473 (+)
CBA/J	MGP_CBAJ_G0021446	protein coding gene	Chr15:9963149-10040413 (+)
DBA/2J	MGP_DBA2J_G0021570	protein coding gene	Chr15:8895823-8971402 (+)
FVB/NJ	MGP_FVBNJ_G0021548	protein coding gene	Chr15:8754255-8824267 (+)
LP/J	MGP_LPJ_G0021638	protein coding gene	Chr15:9263831-9334564 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021573	protein coding gene	Chr15:10194541-10279072 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022163	protein coding gene	Chr15:9288110-9359015 (+)
PWK/PhJ	MGP_PWKPhJ_G0020736	protein coding gene	Chr15:9085419-9156148 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020574	protein coding gene	Chr15:9223503-9301644 (+)
WSB/EiJ	MGP_WSBEiJ_G0021049	protein coding gene	Chr15:9273856-9343162 (+)

Human Ortholog

ZFR, zinc finger RNA binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZFR, zinc finger RNA binding protein
Synonyms

SPG71, ZFR1
Links

HGNC:17277

NCBI Gene ID: 51663

neXtProt AC: NX_Q96KR1

UniProt: Q96KR1
Chr Location

5p13.3; chr5:32354350-32444740 (-) GRCh38

MGI Vertebrate Homology

Zfr stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZFR
Gene Tree

Zfr

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Phenotype Summary

5 phenotypes from 1 allele in 3 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Endonuclease-mediated

1
Gene trapped

20
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

63 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit impaired gastrulation, with increased apoptosis and a low mitotic index, and die between embryonic days 8 and 9.

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

833
Tissues

67
cDNA Data

167
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zfr

ZFIN zfr

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All Sequences

80
RefSeq

19
UniProt

6
CCDS

CCDS37044.2

Ensembl

ENSMUSG00000022201 (Evidence)
NCBI Gene

22763

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022201	Ensembl Gene Model \| MGI Sequence Detail	67853	C57BL/6J	± kb
transcript	ENSMUST00000122941	Ensembl \| MGI Sequence Detail	4850	Not Applicable
polypeptide	ENSMUSP00000118911	Ensembl \| MGI Sequence Detail	1074	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000017654 zinc finger RNA-binding protein

(term hierarchy)
InterPro Domains

IPR006561 DZF domain

IPR049402 DZF domain, C-terminal

IPR049401 DZF domain, N-terminal

IPR003604 Matrin/U1-C-like, C2H2-type zinc finger

IPR043519 Nucleotidyltransferase superfamily

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

O88532 16 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (15 sites)

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All nucleic 172

cDNA 171

Primer pair 1

Microarray probesets 7

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MGI:2441929

Summaries

All 38

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 7
Earliest

J:53504 Meagher MJ, et al., Identification of ZFR, an ancient and highly conserved murine chromosome-associated zinc finger protein. Gene. 1999 Mar 4;228(1-2):197-211
Latest

J:190636 Wiese CB, et al., A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130

TSS for Zfr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130711	Chr15:12117670-12117698 (+)	-233 bp
Tssr130712	Chr15:12117868-12117881 (+)	-42 bp
Tssr130713	Chr15:12117899-12117932 (+)	-1 bp
Tssr130714	Chr15:12117934-12117991 (+)	46 bp
Tssr130715	Chr15:12118118-12118160 (+)	222 bp
Tssr130716	Chr15:12122944-12122946 (+)	5,028 bp
Tssr130717	Chr15:12129591-12129597 (+)	11,677 bp
Tssr130718	Chr15:12136655-12136674 (+)	18,748 bp
Tssr130719	Chr15:12146243-12146287 (+)	28,348 bp
Tssr130720	Chr15:12146361-12146372 (+)	28,450 bp
Tssr130721	Chr15:12149398-12149401 (+)	31,483 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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