Slc27a3 MGI Mouse Gene Detail - MGI:1347358 - solute carrier family 27 (fatty acid transporter), member 3

Symbol

Slc27a3
Name

solute carrier family 27 (fatty acid transporter), member 3
Synonyms

Acsvl3, FATP3, fatty acid transport protein 3

Feature Type

protein coding gene
IDs

MGI:1347358
NCBI Gene: 26568
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:90292546-90297245 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.22 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

145 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347358	protein coding gene	Chr3:90292540-90298693 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027462	protein coding gene	Chr3:90693982-90698681 (-)
A/J	MGP_AJ_G0027426	protein coding gene	Chr3:87674367-87679153 (-)
AKR/J	MGP_AKRJ_G0027391	protein coding gene	Chr3:89831585-89836284 (-)
BALB/cJ	MGP_BALBcJ_G0027435	protein coding gene	Chr3:87630848-87635547 (-)
C3H/HeJ	MGP_C3HHeJ_G0027177	protein coding gene	Chr3:89993937-89998636 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027881	protein coding gene	Chr3:94097296-94101995 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025234	protein coding gene	Chr3:83167719-83172650 (-)
CAST/EiJ	MGP_CASTEiJ_G0026623	protein coding gene	Chr3:90375174-90381712 (-)
CBA/J	MGP_CBAJ_G0027152	protein coding gene	Chr3:97325682-97330347 (-)
DBA/2J	MGP_DBA2J_G0027289	protein coding gene	Chr3:87041662-87046298 (-)
FVB/NJ	MGP_FVBNJ_G0027257	protein coding gene	Chr3:85375828-85380617 (-)
LP/J	MGP_LPJ_G0027398	protein coding gene	Chr3:91756964-91763334 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027278	protein coding gene	Chr3:103541302-103546927 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027940	protein coding gene	Chr3:89573274-89577924 (-)
PWK/PhJ	MGP_PWKPhJ_G0026357	protein coding gene	Chr3:86932745-86938077 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026177	protein coding gene	Chr3:88752949-88757639 (-)
WSB/EiJ	MGP_WSBEiJ_G0026705	protein coding gene	Chr3:89975475-89980174 (-)

Human Ortholog

SLC27A3, solute carrier family 27 member 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC27A3, solute carrier family 27 member 3
Synonyms

ACSVL3, FATP3, VLCS-3
Links

HGNC:10997

NCBI Gene ID: 11000

neXtProt AC: NX_Q5K4L6

UniProt: Q5K4L6
Chr Location

1q21.3; chr1:153774354-153780157 (+) GRCh38

MGI Vertebrate Homology

Slc27a3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SLC27A3
Gene Tree

Slc27a3

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Slc27a3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

26
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

809
Tissues

103
cDNA Data

23
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase LOC100494612

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All Sequences

51
RefSeq

8
UniProt

5
CCDS

CCDS17527.1

Ensembl

ENSMUSG00000027932 (Evidence)
NCBI Gene

26568

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027932	Ensembl Gene Model \| MGI Sequence Detail	4700	C57BL/6J	± kb
transcript	ENSMUST00000029541	Ensembl \| MGI Sequence Detail	2259	Not Applicable
polypeptide	ENSMUSP00000029541	Ensembl \| MGI Sequence Detail	667	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015047 long-chain fatty acid transport protein 3

(term hierarchy)
EC

6.2.1.-, 6.2.1.15, 6.2.1.3
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR025110 AMP-binding enzyme, C-terminal domain

IPR045851 AMP-binding enzyme, C-terminal domain superfamily

IPR000873 AMP-dependent synthetase/ligase domain

IPR042099 ANL, N-terminal domain

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All nucleic 24

cDNA 23

Primer pair 1

Microarray probesets 3

Summaries

All 47

Developmental Gene Expression 9

Diseases 1

Gene Ontology 9

Phenotypes 12
Earliest

J:42634 Hirsch D, et al., A family of fatty acid transporters conserved from mycobacterium to man. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8625-9
Latest

J:327433 Song Z, et al., The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation. Mol Metab. 2022 Jul 19;64:101548

TSS for Slc27a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34210	Chr3:90297270-90297283 (-)	-32 bp
Tssr34209	Chr3:90297243-90297265 (-)	-9 bp
Tssr34208	Chr3:90297191-90297231 (-)	34 bp
Tssr34207	Chr3:90297156-90297169 (-)	82 bp
Tssr34206	Chr3:90296588-90296626 (-)	638 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24