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F2rl3 Gene Detail
Summary
  • Symbol
    F2rl3
  • Name
    F2R like thrombin or trypsin receptor 3
  • Synonyms
    PAR4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298207
    NCBI Gene: 14065
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:73488508-73490502 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 35.08 cM, cytoband B3.3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298207
 protein coding gene Chr8:73488287-73490526 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033790
 protein coding gene Chr8:73259644-73263003 (+)
A/J MGP_AJ_G0033772
 protein coding gene Chr8:70279345-70281339 (+)
AKR/J MGP_AKRJ_G0033699
 protein coding gene Chr8:72383978-72385811 (+)
BALB/cJ MGP_BALBcJ_G0033766
 protein coding gene Chr8:70416460-70418355 (+)
C3H/HeJ MGP_C3HHeJ_G0033475
 protein coding gene Chr8:72993532-72996215 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034286
 protein coding gene Chr8:76023348-76025342 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031227
 protein coding gene Chr8:64796643-64798631 (+)
CAST/EiJ MGP_CASTEiJ_G0032804
 protein coding gene Chr8:72348482-72353186 (+)
CBA/J MGP_CBAJ_G0033454
 protein coding gene Chr8:78745172-78750370 (+)
DBA/2J MGP_DBA2J_G0033608
 protein coding gene Chr8:70025584-70027578 (+)
FVB/NJ MGP_FVBNJ_G0033553
 protein coding gene Chr8:69107767-69111615 (+)
LP/J MGP_LPJ_G0033697
 protein coding gene Chr8:73335110-73337683 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0034303
 protein coding gene Chr8:72477707-72481596 (+)
PWK/PhJ MGP_PWKPhJ_G0032510
 protein coding gene Chr8:69289225-69291219 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032348
 protein coding gene Chr8:71359273-71361265 (+)
WSB/EiJ MGP_WSBEiJ_G0032919
 protein coding gene Chr8:72740504-72742907 (+)



Homology
more
  • Human Ortholog
    F2RL3, F2R like thrombin or trypsin receptor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    F2RL3, F2R like thrombin or trypsin receptor 3
  • Synonyms
    PAR4
  • Links
    NCBI Gene ID: 9002
    neXtProt AC: NX_Q96RI0
    UniProt: Q96RI0

  • Chr Location
    19p13.11; chr19:16888999-16892606 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 1 genetic background
    1 phenotype from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in prolonged bleeding time and protection against thrombosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    39
  • cDNA Data
    12
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050147 Ensembl Gene Model | MGI Sequence Detail 1995 C57BL/6J ±  kb
transcript ENSMUST00000058099 Ensembl | MGI Sequence Detail 1751 Not Applicable  
polypeptide ENSMUSP00000054426 Ensembl | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 4
    cDNA 12

    Microarray probesets 3
References
more
  • Summaries
    All 95
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 47
  • Earliest
    J:49283 Kahn ML, et al., A dual thrombin receptor system for platelet activation. Nature. 1998 Aug 13;394(6694):690-4
  • Latest
    J:341059 Denorme F, et al., The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes. J Clin Invest. 2023 Sep 15;133(18)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory