Stk16 MGI Mouse Gene Detail - MGI:1313271 - serine/threonine kinase 16

Symbol

Stk16
Name

serine/threonine kinase 16
Synonyms

EDPK, Embryo-Derived Protein Kinase, Krct, PKL12

Feature Type

protein coding gene
IDs

MGI:1313271
NCBI Gene: 20872
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:75187482-75192250 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 38.63 cM
Mapping Data

4 experiments

SNPs within 2kb

101 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1313271	protein coding gene	Chr1:75187463-75192250 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016178	protein coding gene	Chr1:75774968-75779736 (+)
A/J	MGP_AJ_G0016161	protein coding gene	Chr1:73133558-73138326 (+)
AKR/J	MGP_AKRJ_G0016118	protein coding gene	Chr1:75162728-75167496 (+)
BALB/cJ	MGP_BALBcJ_G0016116	protein coding gene	Chr1:73194523-73199291 (+)
C3H/HeJ	MGP_C3HHeJ_G0015947	protein coding gene	Chr1:75495941-75500709 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016569	protein coding gene	Chr1:78723358-78728816 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014290	protein coding gene	Chr1:68693973-68698301 (+)
CAST/EiJ	MGP_CASTEiJ_G0015531	protein coding gene	Chr1:74833842-74838610 (+)
CBA/J	MGP_CBAJ_G0015920	protein coding gene	Chr1:81284436-81289204 (+)
DBA/2J	MGP_DBA2J_G0016021	protein coding gene	Chr1:72451771-72456539 (+)
FVB/NJ	MGP_FVBNJ_G0016024	protein coding gene	Chr1:71650713-71655481 (+)
LP/J	MGP_LPJ_G0016093	protein coding gene	Chr1:76899241-76904009 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016044	protein coding gene	Chr1:84642495-84647263 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016616	protein coding gene	Chr1:75233740-75238508 (+)
PWK/PhJ	MGP_PWKPhJ_G0015318	protein coding gene	Chr1:71922061-71926830 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015096	protein coding gene	Chr1:74591843-74596603 (+)
WSB/EiJ	MGP_WSBEiJ_G0015593	protein coding gene	Chr1:75045655-75050424 (+)

Human Ortholog

STK16, serine/threonine kinase 16

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STK16, serine/threonine kinase 16
Synonyms

hPSK, KRCT, MPSK, PKL12, PSK, TSF1
Links

HGNC:11394

NCBI Gene ID: 8576

neXtProt AC: NX_O75716

UniProt: O75716
Chr Location

2q35; chr2:219245455-219250337 (+) GRCh38

MGI Vertebrate Homology

Stk16 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STK16
Protein SuperFamily

Integrin-linked_kinase
Gene Tree

Stk16

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

5
Radiation induced

2
Spontaneous

1
Targeted

4
Genomic Mutations

4 involving Stk16
Incidental Mutations

CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

28
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

782
Tissues

46
cDNA Data

17
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stk16

ZFIN stk16

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All Sequences

92
RefSeq

15
UniProt

7
CCDS

CCDS15067.1

Ensembl

ENSMUSG00000026201 (Evidence)
NCBI Gene

20872

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026201	Ensembl Gene Model \| MGI Sequence Detail	4769	C57BL/6J	± kb
transcript	ENSMUST00000027401	Ensembl \| MGI Sequence Detail	2876	Not Applicable
polypeptide	ENSMUSP00000027401	Ensembl \| MGI Sequence Detail	305	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000015742 serine/threonine-protein kinase 16

(term hierarchy)
EC

2.7.10.2, 2.7.11.1
InterPro Domains

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR052239 Serine/threonine-specific protein kinases

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All nucleic 18

cDNA 18

Microarray probesets 4

Summaries

All 70

Developmental Gene Expression 7

Diseases 1

Gene Ontology 10

Phenotypes 32
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Stk16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7499	Chr1:75187476-75187554 (+)	33 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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