About   Help   FAQ
Orc4 Gene Detail
Summary
  • Symbol
    Orc4
  • Name
    origin recognition complex, subunit 4
  • Synonyms
    mMmORC4, Orc4, Orc4l, Orc4P
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347043
    NCBI Gene: 26428
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:48792836-48840287 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 28.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1083 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347043
 protein coding gene Chr2:48792836-48840289 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025720
 protein coding gene Chr2:48044717-48093321 (-)
A/J MGP_AJ_G0025696
 protein coding gene Chr2:46225630-46274224 (-)
AKR/J MGP_AKRJ_G0025666
 protein coding gene Chr2:47566214-47617355 (-)
BALB/cJ MGP_BALBcJ_G0025691
 protein coding gene Chr2:46344163-46395210 (-)
C3H/HeJ MGP_C3HHeJ_G0025452
 protein coding gene Chr2:47539580-47587807 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026137
 protein coding gene Chr2:49529007-49579429 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023543
 protein coding gene Chr2:44292069-44342143 (-)
CAST/EiJ MGP_CASTEiJ_G0024917
 protein coding gene Chr2:47585867-47636007 (-)
CBA/J MGP_CBAJ_G0025432
 protein coding gene Chr2:51388430-51437596 (-)
DBA/2J MGP_DBA2J_G0025563
 protein coding gene Chr2:45857685-45906560 (-)
FVB/NJ MGP_FVBNJ_G0025525
 protein coding gene Chr2:45580120-45629423 (-)
LP/J MGP_LPJ_G0025651
 protein coding gene Chr2:47963585-48016105 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025556
 protein coding gene Chr2:52349970-52403233 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026195
 protein coding gene Chr2:47463697-47514000 (-)
PWK/PhJ MGP_PWKPhJ_G0024658
 protein coding gene Chr2:45735428-45783759 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024463
 protein coding gene Chr2:47616124-47662880 (-)
WSB/EiJ MGP_WSBEiJ_G0024984
 protein coding gene Chr2:47700473-47748566 (-)



Homology
more
  • Human Ortholog
    ORC4, origin recognition complex subunit 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ORC4, origin recognition complex subunit 4
  • Synonyms
    ORC4L, ORC4P
  • Links
    NCBI Gene ID: 5000
    neXtProt AC: NX_O43929
    UniProt: O43929

  • Chr Location
    2q23.1; chr2:147930396-148021604 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ORC4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in oocytes exhibit female infertility due to failure of polar body extrusion, impaired DNA synthesis, and arrested female meiosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    3
  • cDNA Data
    22
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26428 NCBI Gene Model | MGI Sequence Detail 47452 C57BL/6J ±  kb
    transcript NM_001355296 RefSeq | MGI Sequence Detail 4064 C57BL/6  
    polypeptide O88708 UniProt | EBI | MGI Sequence Detail 433 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 25
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 13
    • Earliest
      J:43876 Tugal T, et al., The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. J Biol Chem. 1998 Dec 4;273(49):32421-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory