Zfand5 MGI Mouse Gene Detail - MGI:1278334 - zinc finger, AN1-type domain 5

Symbol

Zfand5
Name

zinc finger, AN1-type domain 5
Synonyms

2310057A04Rik, 5830475F03Rik, Za20d2, Zfp216

Feature Type

protein coding gene
IDs

MGI:1278334
NCBI Gene: 22682
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr19:21249642-21264204 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 14.32 cM
Mapping Data

4 experiments

SNPs within 2kb

409 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1278334	protein coding gene	Chr19:21249150-21264204 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024976	protein coding gene	Chr19:19293336-19301997 (+)
A/J	MGP_AJ_G0024953	protein coding gene	Chr19:18238330-18257225 (+)
AKR/J	MGP_AKRJ_G0024923	protein coding gene	Chr19:18942621-18954407 (+)
BALB/cJ	MGP_BALBcJ_G0024952	protein coding gene	Chr19:18251195-18261224 (+)
C3H/HeJ	MGP_C3HHeJ_G0024710	protein coding gene	Chr19:18898924-18908610 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025394	protein coding gene	Chr19:19960654-19974065 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022813	protein coding gene	Chr19:18488783-18498836 (+)
CAST/EiJ	MGP_CASTEiJ_G0024178	protein coding gene	Chr19:18555504-18571934 (+)
CBA/J	MGP_CBAJ_G0024688	protein coding gene	Chr19:20776844-20786614 (+)
DBA/2J	MGP_DBA2J_G0024820	protein coding gene	Chr19:18256380-18268938 (+)
FVB/NJ	MGP_FVBNJ_G0024781	protein coding gene	Chr19:18113033-18123043 (+)
LP/J	MGP_LPJ_G0024904	protein coding gene	Chr19:19265908-19277842 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024808	protein coding gene	Chr19:20908527-20917454 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025449	protein coding gene	Chr19:18876933-18887362 (+)
PWK/PhJ	MGP_PWKPhJ_G0023927	protein coding gene	Chr19:17788502-17802282 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023732	protein coding gene	Chr19:18152446-18159438 (+)
WSB/EiJ	MGP_WSBEiJ_G0024246	protein coding gene	Chr19:18960351-18969095 (+)

Human Ortholog

ZFAND5, zinc finger AN1-type containing 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZFAND5, zinc finger AN1-type containing 5
Synonyms

ZA20D2, ZFAND5A, ZNF216
Links

HGNC:13008

NCBI Gene ID: 7763

neXtProt AC: NX_O76080

UniProt: O76080
Chr Location

9q21.13; chr9:72351413-72365235 (-) GRCh38

MGI Vertebrate Homology

Zfand5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ZFAND5
Gene Tree

Zfand5

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Endonuclease-mediated

1
Gene trapped

23
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display resistance to age related obesity and resistance to induced muscular atrophy.

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All GO Annotations

11
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

829
Tissues

118
cDNA Data

22
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zfand5

ZFIN zfand5a

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All Sequences

66
RefSeq

4
UniProt

2
CCDS

CCDS29697.1

Ensembl

ENSMUSG00000024750 (Evidence)
NCBI Gene

22682

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024750	Ensembl Gene Model \| MGI Sequence Detail	14563	C57BL/6J	± kb
transcript	ENSMUST00000237651	Ensembl \| MGI Sequence Detail	7385	Not Applicable
polypeptide	ENSMUSP00000158187	Ensembl \| MGI Sequence Detail	213	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017624 AN1-type zinc finger protein 5

(term hierarchy)
PDB

1WFL
InterPro Domains

IPR050652 AN1/A20 Zinc Finger

IPR035896 AN1-like Zinc finger

IPR002653 Zinc finger, A20-type

IPR000058 Zinc finger, AN1-type
GlyGen

O88878 1 site, 1 N-linked glycan (1 site)

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All nucleic 27

Genomic 1

cDNA 24

Primer pair 1

Other 1

Microarray probesets 12

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MGI:1919194, MGI:1923353, MGI:2145558

Summaries

All 43

Developmental Gene Expression 9

Gene Ontology 3

Phenotypes 7
Earliest

J:49546 Scott DA, et al., Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. Gene. 1998 Jul 30;215(2):461-9
Latest

J:266562 Lee D, et al., ZFAND5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9550-E9559

TSS for Zfand5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155485	Chr19:21249214-21249254 (+)	-408 bp
Tssr155486	Chr19:21249621-21249627 (+)	-18 bp
Tssr155487	Chr19:21249640-21249660 (+)	8 bp
Tssr155488	Chr19:21249880-21249906 (+)	251 bp
Tssr155489	Chr19:21251800-21251817 (+)	2,167 bp
Tssr155490	Chr19:21252414-21252443 (+)	2,787 bp
Tssr155491	Chr19:21253802-21253821 (+)	4,170 bp
Tssr155492	Chr19:21253823-21253840 (+)	4,190 bp
Tssr155493	Chr19:21255064-21255087 (+)	5,434 bp
Tssr155494	Chr19:21255536-21255538 (+)	5,895 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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