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Pias1 Gene Detail
Summary
  • Symbol
    Pias1
  • Name
    protein inhibitor of activated STAT 1
  • Synonyms
    2900068C24Rik, Ddxbp1, GBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913125
    NCBI Gene: 56469
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:62785648-62888161 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 33.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1708 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913125
 protein coding gene Chr9:62785648-62895206 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034926
 protein coding gene Chr9:62449638-62560298 (-)
A/J MGP_AJ_G0034906
 protein coding gene Chr9:60381416-60483359 (-)
AKR/J MGP_AKRJ_G0034836
 protein coding gene Chr9:61787932-61892118 (-)
BALB/cJ MGP_BALBcJ_G0034899
 protein coding gene Chr9:60108630-60212386 (-)
C3H/HeJ MGP_C3HHeJ_G0034609
 protein coding gene Chr9:62291974-62405066 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035418
 protein coding gene Chr9:64172230-64281834 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032329
 protein coding gene Chr9:60033985-60138364 (-)
CAST/EiJ MGP_CASTEiJ_G0033930
 protein coding gene Chr9:62438597-62544713 (-)
CBA/J MGP_CBAJ_G0034580
 protein coding gene Chr9:66376803-66490100 (-)
DBA/2J MGP_DBA2J_G0034739
 protein coding gene Chr9:60175840-60277311 (-)
FVB/NJ MGP_FVBNJ_G0034681
 protein coding gene Chr9:59464637-59571300 (-)
LP/J MGP_LPJ_G0034822
 protein coding gene Chr9:62733793-62843251 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034724
 protein coding gene Chr9:67721916-67831636 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035440
 protein coding gene Chr9:61871614-61976476 (-)
PWK/PhJ MGP_PWKPhJ_G0033634
 protein coding gene Chr9:60302034-60405046 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033468
 protein coding gene Chr9:62143528-62244957 (-)
WSB/EiJ MGP_WSBEiJ_G0034043
 protein coding gene Chr9:61778055-61885021 (-)



Homology
more
  • Human Ortholog
    PIAS1, protein inhibitor of activated STAT 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIAS1, protein inhibitor of activated STAT 1
  • Synonyms
    DDXBP1, GBP, GU/RH-II, ZMIZ3
  • Links
    NCBI Gene ID: 8554
    neXtProt AC: NX_O75925
    UniProt: O75925

  • Chr Location
    15q23; chr15:68054309-68198603 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display partial perinatal lethality, reduced body size, decreased susceptibility to viral infection, and increased susceptibility to bacterial infection and LPS-induced endotoxin shock.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    828
  • Tissues
    106
  • cDNA Data
    16
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56469 NCBI Gene Model | MGI Sequence Detail 102514 C57BL/6J ±  kb
    transcript NM_019663 RefSeq | MGI Sequence Detail 3855 C57BL/6  
    polypeptide O88907 UniProt | EBI | MGI Sequence Detail 651 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 17
      Primer pair 4
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920216
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 16
      Gene Ontology 23
      Phenotypes 17
    • Earliest
      J:55317 Liu B, et al., Inhibition of Stat1-mediated gene activation by PIAS1. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10626-31
    • Latest
      J:338294 Wang G, et al., PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence. PLoS Pathog. 2022 Apr;18(4):e1010446
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory