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F10 Gene Detail
Summary
  • Symbol
    F10
  • Name
    coagulation factor X
  • Synonyms
    AI194738, Cf10, fX
  • Feature Type
    protein coding gene
  • IDs
    MGI:103107
    NCBI Gene: 14058
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:13087308-13106676 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 5.73 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    748 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103107
 protein coding gene Chr8:13087308-13106676 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033369
 protein coding gene Chr8:10349865-10369343 (+)
A/J MGP_AJ_G0033349
 protein coding gene Chr8:9982761-10002111 (+)
AKR/J MGP_AKRJ_G0033280
 protein coding gene Chr8:10248213-10266790 (+)
BALB/cJ MGP_BALBcJ_G0033350
 protein coding gene Chr8:10123157-10141417 (+)
C3H/HeJ MGP_C3HHeJ_G0033063
 protein coding gene Chr8:10459942-10478511 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033862
 protein coding gene Chr8:10716801-10736148 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030831
 protein coding gene Chr8:9490030-9511556 (+)
CAST/EiJ MGP_CASTEiJ_G0032385
 protein coding gene Chr8:10221419-10241058 (+)
CBA/J MGP_CBAJ_G0033036
 protein coding gene Chr8:11167698-11188921 (+)
DBA/2J MGP_DBA2J_G0033189
 protein coding gene Chr8:9941589-9960156 (+)
FVB/NJ MGP_FVBNJ_G0033138
 protein coding gene Chr8:9946395-9965110 (+)
LP/J MGP_LPJ_G0033283
 protein coding gene Chr8:10272963-10292776 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033172
 protein coding gene Chr8:11424375-11443720 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033879
 protein coding gene Chr8:10312247-10330797 (+)
PWK/PhJ MGP_PWKPhJ_G0032098
 protein coding gene Chr8:9986371-10006337 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031940
 protein coding gene Chr8:10200756-10219714 (+)
WSB/EiJ MGP_WSBEiJ_G0032501
 protein coding gene Chr8:10346884-10370210 (+)



Homology
more
  • Human Ortholog
    F10, coagulation factor X
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    F10, coagulation factor X
  • Synonyms
    FX, FXA
  • Links
    NCBI Gene ID: 2159
    neXtProt AC: NX_P00742
    UniProt: P00742

  • Chr Location
    13q34; chr13:113122799-113149529 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human F10 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 4 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most homozygous mice die from fatal bleeding events at embryonic and neonatal stages, with the remaining homozygous mice dying before weaning stages.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    26
  • cDNA Data
    43
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14058 NCBI Gene Model | MGI Sequence Detail 19369 C57BL/6J ±  kb
    transcript NM_001242368 RefSeq | MGI Sequence Detail 2693 C57BL/6  
    polypeptide O88947 UniProt | EBI | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000007294 coagulation factor X
      (term hierarchy)
    • EC
      3.4.21.6
    • InterPro Domains
      IPR017857 Coagulation factor-like, Gla domain superfamily
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
      IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
      IPR050442 Peptidase S1 family, coagulation factors
      IPR009003 Peptidase S1, PA clan
      IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    • GlyGen
      O88947 2 sites
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 3
      cDNA 45
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-23971, MGI:2142475
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:24375 Koizumi T, et al., Homologs of genes and anonymous loci on human chromosome 13 map to mouse chromosomes 8 and 14. Mamm Genome. 1995 Apr;6(4):263-8
    • Latest
      J:358512 Verhenne S, et al., Fitusiran reduces bleeding in factor X-deficient mice. Blood. 2024 Jul 11;144(2):227-236
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory