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Cyp8b1 Gene Detail
Summary
  • Symbol
    Cyp8b1
  • Name
    cytochrome P450, family 8, subfamily b, polypeptide 1
  • Synonyms
    sterol 12-alpha-hydrolase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338044
    NCBI Gene: 13124
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:121743422-121745371 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 72.73 cM, cytoband F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338044
 protein coding gene Chr9:121743422-121745371 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035454
 protein coding gene Chr9:124881244-124883193 (-)
A/J MGP_AJ_G0035435
 protein coding gene Chr9:120124296-120126245 (-)
AKR/J MGP_AKRJ_G0035368
 protein coding gene Chr9:123329582-123331531 (-)
BALB/cJ MGP_BALBcJ_G0035431
 protein coding gene Chr9:120035627-120037576 (-)
C3H/HeJ MGP_C3HHeJ_G0035138
 protein coding gene Chr9:123783979-123785928 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035954
 protein coding gene Chr9:128302631-128304580 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032836
 protein coding gene Chr9:117280986-117282935 (-)
CAST/EiJ MGP_CASTEiJ_G0034443
 protein coding gene Chr9:123834352-123836301 (-)
CBA/J MGP_CBAJ_G0035106
 protein coding gene Chr9:133000975-133002924 (-)
DBA/2J MGP_DBA2J_G0035265
 protein coding gene Chr9:119567057-119569006 (-)
FVB/NJ MGP_FVBNJ_G0035212
 protein coding gene Chr9:118483983-118485932 (-)
LP/J MGP_LPJ_G0035344
 protein coding gene Chr9:125217381-125219330 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035253
 protein coding gene Chr9:133918085-133920034 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035973
 protein coding gene Chr9:123768105-123770054 (-)
PWK/PhJ MGP_PWKPhJ_G0034147
 protein coding gene Chr9:120022445-120024393 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033984
 protein coding gene Chr9:123890423-123892372 (-)
WSB/EiJ MGP_WSBEiJ_G0034563
 protein coding gene Chr9:123626415-123628364 (-)



Homology
more
  • Human Ortholog
    CYP8B1, cytochrome P450 family 8 subfamily B member 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP8B1, cytochrome P450 family 8 subfamily B member 1
  • Synonyms
    CP8B, CYP12, CYPVIIIB1
  • Links
    NCBI Gene ID: 1582
    neXtProt AC: NX_Q9UNU6
    UniProt: Q9UNU6

  • Chr Location
    3p22.1; chr3:42856005-42875898 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele lack synthsesis of cholate (a primary bile acid) and its metabolites and display an increased bile acid pool and alterations in cholesterol metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    814
  • Tissues
    106
  • cDNA Data
    26
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13124 NCBI Gene Model | MGI Sequence Detail 1950 C57BL/6J ±  kb
    transcript NM_010012 RefSeq | MGI Sequence Detail 1950 ZRU/MplStud  
    polypeptide O88962 UniProt | EBI | MGI Sequence Detail 500 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 1
      cDNA 26
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:53496 Gafvels M, et al., Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Genomics. 1999 Mar 1;56(2):184-96
    • Latest
      J:333765 O'Leary CE, et al., Bile acid-sensitive tuft cells regulate biliary neutrophil influx. Sci Immunol. 2022 Mar 4;7(69):eabj1080
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    10/29/2024
    MGI 6.24     		The Jackson Laboratory