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Matn4 Gene Detail
Summary
  • Symbol
    Matn4
  • Name
    matrilin 4
  • Synonyms
    matrilin-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328314
    NCBI Gene: 17183
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164231313-164247080 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.16 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    599 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328314
 protein coding gene Chr2:164231313-164247080 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026849
 protein coding gene Chr2:169822562-169840291 (-)
A/J MGP_AJ_G0026815
 protein coding gene Chr2:162916693-162932892 (-)
AKR/J MGP_AKRJ_G0026786
 protein coding gene Chr2:167759154-167774187 (-)
BALB/cJ MGP_BALBcJ_G0026824
 protein coding gene Chr2:163278518-163293978 (-)
C3H/HeJ MGP_C3HHeJ_G0026566
 protein coding gene Chr2:168112904-168129371 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027272
 protein coding gene Chr2:174742116-174758373 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024642
 protein coding gene Chr2:156326198-156342993 (-)
CAST/EiJ MGP_CASTEiJ_G0026026
 protein coding gene Chr2:168531850-168549747 (-)
CBA/J MGP_CBAJ_G0026543
 protein coding gene Chr2:181079056-181099976 (-)
DBA/2J MGP_DBA2J_G0026681
 protein coding gene Chr2:162088912-162103979 (-)
FVB/NJ MGP_FVBNJ_G0026647
 protein coding gene Chr2:160500230-160515526 (-)
LP/J MGP_LPJ_G0026784
 protein coding gene Chr2:169912438-169927429 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026667
 protein coding gene Chr2:184683459-184699911 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027328
 protein coding gene Chr2:167660525-167675531 (-)
PWK/PhJ MGP_PWKPhJ_G0025761
 protein coding gene Chr2:161663557-161679561 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025562
 protein coding gene Chr2:166532917-166547936 (-)
WSB/EiJ MGP_WSBEiJ_G0026097
 protein coding gene Chr2:168516930-168532903 (-)



Homology
more
  • Human Ortholog
    MATN4, matrilin 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MATN4, matrilin 4
  • Links
    NCBI Gene ID: 8785
    neXtProt AC: NX_O95460
    UniProt: O95460

  • Chr Location
    20q13.12; chr20:45293445-45308684 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased LSK cell numbers and increased competitive repopulation capacity of HSCs in bone marrow transplantations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    796
  • Tissues
    78
  • cDNA Data
    25
  • Literature Summary
    15
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17183 NCBI Gene Model | MGI Sequence Detail 15768 C57BL/6J ±  kb
transcript NM_013592 RefSeq | MGI Sequence Detail 2508 ZRU/MplStud  
polypeptide O89029 UniProt | EBI | MGI Sequence Detail 624 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010208 matrilin-4
    (term hierarchy)
  • InterPro Domains
    IPR001881 EGF-like calcium-binding domain
    IPR000742 EGF-like domain
    IPR050525 Extracellular Matrix Assembly and Organization
    IPR009030 Growth factor receptor cysteine-rich domain superfamily
    IPR036337 Matrilin, coiled-coil domain superfamily
    IPR019466 Matrilin, coiled-coil trimerisation domain
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
  • GlyGen
    O89029 2 sites, 3 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 28
    Genomic 1
    cDNA 25
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 43
    Developmental Gene Expression 15
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:50116 Wagener R, et al., Matrilin-4, a new member of the matrilin family of extracellular matrix proteins. FEBS Lett. 1998 Sep 25;436(1):123-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory