Ren2 MGI Mouse Gene Detail - MGI:97899 - renin 2 tandem duplication of Ren1

Ren2 Gene Detail

Symbol

Ren2
Name

renin 2 tandem duplication of Ren1
Synonyms

Ren, Ren-2, Ren-B, Rn-2, Rnr

Feature Type

protein coding gene
IDs

MGI:97899
NCBI Gene: 19702
Alliance

gene page

Sequence Map

Genome coordinates not available from the current reference assembly.

Genetic Map

Chromosome 1, Syntenic
Mapping Data

43 experiments

RFLP

10

Strain-Specific Marker

Human Ortholog

REN, renin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

REN, renin
Synonyms

ADTKD4, HNFJ2, RTD
Links

HGNC:9958

NCBI Gene ID: 5972

neXtProt AC: NX_P00797

UniProt: P00797
Chr Location

1q32.1; chr1:204154819-204190324 (-) GRCh38

MGI Vertebrate Homology

Ren2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: REN

Diseases

5 with human REN associations

				Human Disease	Mouse Models
				essential hypertension IDs essential hypertension DOID:10825 ICD10CM:I10 ICD9CM:401 ICD9CM:401.9 MESH:D000075222 NCI:C3478 OMIM:145500 OMIM:603918 OMIM:604329 OMIM:607329 OMIM:608742 OMIM:610261 OMIM:610262 OMIM:610948 OMIM:611014 ORDO:243761 UMLS_CUI:C0085580
				familial juvenile hyperuricemic nephropathy IDs familial juvenile hyperuricemic nephropathy DOID:0060062 OMIM:162000 OMIM:613092 OMIM:614227 ORDO:209886 ORDO:217330
				hand, foot and mouth disease IDs hand, foot and mouth disease DOID:10881 ICD10CM:B08.4 ICD9CM:074.3 MESH:D006232 NCI:C128439 UMLS_CUI:C0018572
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				portal hypertension IDs portal hypertension DOID:10762 ICD10CM:K76.6 ICD9CM:572.3 MESH:D006975 NCI:C3119 UMLS_CUI:C0020541

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype reference

All Mutations and Alleles

1
Targeted

1
Incidental Mutations

CvDC
Find Mice (IMSR)

0 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a targeted null mutation are viable and fertile; no defects in the function of the renin-angiotensin system were detected and blood pressure regulation was normal.

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All GO Annotations

27
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

50
Tissues

11
cDNA Data

5
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

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All Sequences

11
RefSeq

2
UniProt

2

NCBI Gene

19702

			Length	Strain/Species	Flank
genomic	K02597	GenBank \| ENA \| DDBJ \| MGI Sequence Detail	640	Not Specified	± kb
transcript	NM_031193	RefSeq \| MGI Sequence Detail	1547	FVB/N
polypeptide	P00796	UniProt \| EBI \| MGI Sequence Detail	401	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014395 renin-2

(term hierarchy)
PDB

1SMR
EC

3.4.23.15
InterPro Domains

IPR001461 Aspartic peptidase A1 family

IPR001969 Aspartic peptidase, active site

IPR021109 Aspartic peptidase domain superfamily

IPR012848 Aspartic peptidase, N-terminal

IPR033121 Peptidase family A1 domain

IPR034135 Renin-like domain

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All nucleic 29

Genomic 10

cDNA 16

Primer pair 1

Other 2

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MGD-MRK-13833, MGD-MRK-13834, MGD-MRK-13835, MGD-MRK-13837, MGD-MRK-13839, MGD-MRK-13918, MGD-MRK-13951

Summaries

All 94

Developmental Gene Expression 13

Gene Ontology 7

Phenotypes 1
Earliest

J:5794 Wilson CM, et al., Genetic control of renin activity in the submaxillary gland of the mouse. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1185-9
Latest

J:333395 Gunawardhana KL, et al., A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension. J Clin Invest. 2023 Feb 15;133(4)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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