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Il2ra Gene Detail
Summary
  • Symbol
    Il2ra
  • Name
    interleukin 2 receptor, alpha chain
  • Synonyms
    CD25, Il2r, IL-2R alpha chain, Ly-43
  • Feature Type
    protein coding gene
  • IDs
    MGI:96549
    NCBI Gene: 16184
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:11647618-11698004 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 8.91 cM, cytoband A2-A3
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1640 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96549
 protein coding gene Chr2:11647603-11698005 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025346
 protein coding gene Chr2:9062673-9113767 (+)
A/J MGP_AJ_G0025323
 protein coding gene Chr2:8678380-8731658 (+)
AKR/J MGP_AKRJ_G0025292
 protein coding gene Chr2:8988266-9040769 (+)
BALB/cJ MGP_BALBcJ_G0025319
 protein coding gene Chr2:8660296-8714535 (+)
C3H/HeJ MGP_C3HHeJ_G0025079
 protein coding gene Chr2:8901494-8950726 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025761
 protein coding gene Chr2:9304532-9362648 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023176
 protein coding gene Chr2:8114413-8161448 (+)
CAST/EiJ MGP_CASTEiJ_G0024542
 protein coding gene Chr2:8936111-8988392 (+)
CBA/J MGP_CBAJ_G0025058
 protein coding gene Chr2:9687031-9755615 (+)
DBA/2J MGP_DBA2J_G0025190
 protein coding gene Chr2:8595792-8646459 (+)
FVB/NJ MGP_FVBNJ_G0025152
 protein coding gene Chr2:8519627-8567086 (+)
LP/J MGP_LPJ_G0025276
 protein coding gene Chr2:8976216-9026473 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025184
 protein coding gene Chr2:9578223-9634379 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025819
 protein coding gene Chr2:8908709-8962114 (+)
PWK/PhJ MGP_PWKPhJ_G0024293
 protein coding gene Chr2:8569985-8621054 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024093
 protein coding gene Chr2:8899340-8956175 (+)
WSB/EiJ MGP_WSBEiJ_G0024612
 protein coding gene Chr2:8978186-9028617 (+)



Homology
more
  • Human Ortholog
    IL2RA, interleukin 2 receptor subunit alpha
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL2RA, interleukin 2 receptor subunit alpha
  • Synonyms
    CD25, IDDM10, IL2R, IMD41, p55, TCGFR
  • Links
    NCBI Gene ID: 3559
    neXtProt AC: NX_P01589
    UniProt: P01589

  • Chr Location
    10p15.1; chr10:6010689-6062370 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Il2ra mouse models; 5 with human IL2RA associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 3 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    105 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit massive proliferation of polyclonal T and B cells as adults and develop autoimmune disorders including inflammatory bowel disease and hemolytic anemia with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    37
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    6
  • cDNA Data
    28
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026770 Ensembl Gene Model | MGI Sequence Detail 50387 C57BL/6J ±  kb
    transcript ENSMUST00000028111 Ensembl | MGI Sequence Detail 4412 Not Applicable  
    polypeptide ENSMUSP00000028111 Ensembl | MGI Sequence Detail 268 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 28
      Primer pair 2
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11375, MGD-MRK-11376, MGD-MRK-11985
    References
    more
    • Summaries
      All 270
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 37
      Phenotypes 105
    • Earliest
      J:7554 Ortega G, et al., The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells. J Immunol. 1984 Oct;133(4):1970-5
    • Latest
      J:357773 Sommer C, et al., Interleukin-2-induced skin inflammation. Eur J Immunol. 2024 Mar 2;:e2350580
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory