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Tcra Complex/Cluster/Region Detail
Summary
  • Symbol
    Tcra
  • Name
    T cell receptor alpha chain
  • Synonyms
    Tcr alpha, Tcralpha
Location &
Maps
more
  • Sequence Map
    Chr14:52665424-54461655 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, cytoband D1-D2
  • Mapping Data
    51 experiments
Strain
Comparison
more
  • SNPs within 2kb
    19816 from dbSNP Build 142
  • PCR
    4
  • RFLP
    6
Human Diseases
more
  • Diseases
    2 with Tcra mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 13 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    13 with disease annotations
  • References
    17 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    77 phenotypes from 11 alleles in 19 genetic backgrounds
    267 phenotypes from multigenic genotypes
    2 images
    6120 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display thymic hypoplasia and aberrant alphabeta T cell development. Inflammatory bowel disease develops as these mice age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    8
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    58
  • Tissues
    29
  • cDNA Data
    2
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Other Mouse Links
      GEO
    Sequences &
    Gene Models
    less
    • All Sequences
      5
    • RefSeq
      1
    • UniProt
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21473 NCBI Gene Model | MGI Sequence Detail 1796232 C57BL/6J ±  kb
    transcript U07662 GenBank | ENA | DDBJ | MGI Sequence Detail 1420 SJL-7A5*  
    polypeptide P01849 UniProt | EBI | MGI Sequence Detail 136 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 2
      Primer pair 4
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14845
    References
    more
    • Summaries
      All 6331
      Developmental Gene Expression 6
      Diseases 17
      Gene Ontology 6
      Phenotypes 6120
    • Earliest
      J:7626 Chien Y, et al., A third type of murine T-cell receptor gene. Nature. 1984 Nov 1-7;312(5989):31-5
    • Latest
      J:357414 Porier DL, et al., Humoral and T-cell-mediated responses to an insect-specific flavivirus-based Zika virus vaccine candidate. PLoS Pathog. 2024 Oct;20(10):e1012566
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory