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early conceptus |
embryo ectoderm |
embryo endoderm |
embryo mesoderm |
embryo mesenchyme |
extraembryonic component |
alimentary system |
auditory system |
branchial arches |
cardiovascular system |
connective tissue |
endocrine system |
exocrine system |
hemolymphoid system |
integumental system |
limbs |
liver and biliary system |
musculoskeletal system |
nervous system |
olfactory system |
reproductive system |
respiratory system |
urinary system |
visual system |
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Transcription Start Site | Location | Distance from Gene 5'-end |
Tssr144334 | Chr17:35481702-35481752 (+) | -343 bp |
Tssr144335 | Chr17:35481778-35481799 (+) | -281 bp |
Tssr144336 | Chr17:35482039-35482050 (+) | -25 bp |
Tssr144337 | Chr17:35482063-35482076 (+) | 0 bp |
Tssr144338 | Chr17:35482267-35482286 (+) | 207 bp |
Tssr144339 | Chr17:35482401-35482433 (+) | 347 bp |
Tssr144340 | Chr17:35482735-35482744 (+) | 670 bp |
Tssr144341 | Chr17:35482840-35482861 (+) | 781 bp |
Tssr144342 | Chr17:35482937-35482966 (+) | 882 bp |
Tssr144343 | Chr17:35483022-35483034 (+) | 958 bp |
Tssr144344 | Chr17:35483373-35483394 (+) | 1,314 bp |
Tssr144345 | Chr17:35483752-35483763 (+) | 1,688 bp |
Tssr144346 | Chr17:35483812-35483826 (+) | 1,749 bp |
Tssr144347 | Chr17:35483867-35483871 (+) | 1,799 bp |
Tssr144348 | Chr17:35484766-35484788 (+) | 2,707 bp |
Tssr144349 | Chr17:35485155-35485228 (+) | 3,122 bp |
Tssr144350 | Chr17:35485980-35486018 (+) | 3,929 bp |
Tssr144351 | Chr17:35486069-35486084 (+) | 4,007 bp |
Tssr144352 | Chr17:35486115-35486169 (+) | 4,072 bp |
Tssr144353 | Chr17:35486227-35486255 (+) | 4,171 bp |
QTL | Genetic Location* | Genome Location (GRCm39) | Reference | QTL Note |
Blmpf1 | Chr17, 17.25 cM | Chr17:32061652-37644775 | J:100369 | Gene expression analysis was used to identify candidate genes for bleomycin-induced pulmonary fibrorsis QTLs Blmpf1 and Blmpf2. These loci were previously mapped in an F2 cross between susceptible strain C57BL/6J and resistant strain C3Hf/Kam. Blmpf1 maps to 17.4 cM on mouse Chromosome 17 and Blmpf2 maps to 28 cM on mouse Chromosome 11. Genes mapping to the Blmpf1 interval on mouse Chromosome 17 were evaluated for lung mRNA expression in C57BL/6J and C3Hf/Kam animals with and without bleomycin treatment. Genes showing significant expression differences with P<0.001 are H2-D1 (19.09 cM), C4 (18.8 cM), Glo1 (16 cM), H2-Q7 (19.19 cM), H2-K (18.65 cM), Gabbr1 (20.4 cM), Tff2 (17 cM), Notch4 (18.72 cM), and Fkbp5 (13 cM). Genes mapping to the Blmpf2 interval on mouse Chromosome 11 were evaluated for lung mRNA expression in C57BL/6J and C3Hf/Kam animals with and without bleomycin treatment. Genes showing significant expression differences with P<0.001 are Scgb3a1 (25 cM), Trim16, Pttg1, and Gria1 (31 cM). |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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