Tk1 MGI Mouse Gene Detail - MGI:98763

Symbol

Tk1
Name

thymidine kinase 1
Synonyms

D530002A18Rik, Tk-1

Feature Type

protein coding gene
IDs

MGI:98763
NCBI Gene: 21877
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:117706352-117716918 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 82.96 cM, cytoband E1-E2
Mapping Data

21 experiments

SNPs within 2kb

384 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98763	protein coding gene	Chr11:117706345-117716918 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019454	protein coding gene	Chr11:122097554-122108333 (-)
A/J	MGP_AJ_G0019422	protein coding gene	Chr11:116686549-116698122 (-)
AKR/J	MGP_AKRJ_G0019392	protein coding gene	Chr11:120238893-120251309 (-)
BALB/cJ	MGP_BALBcJ_G0019397	protein coding gene	Chr11:117058441-117069287 (-)
C3H/HeJ	MGP_C3HHeJ_G0019203	protein coding gene	Chr11:120520497-120533635 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019846	protein coding gene	Chr11:125823736-125834111 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017471	protein coding gene	Chr11:113695401-113705658 (-)
CAST/EiJ	MGP_CASTEiJ_G0018757	protein coding gene	Chr11:121949306-121959712 (-)
CBA/J	MGP_CBAJ_G0019174	protein coding gene	Chr11:130777937-130788855 (-)
DBA/2J	MGP_DBA2J_G0019286	protein coding gene	Chr11:116087628-116098920 (-)
FVB/NJ	MGP_FVBNJ_G0019278	protein coding gene	Chr11:115707352-115717852 (-)
LP/J	MGP_LPJ_G0019356	protein coding gene	Chr11:122422174-122433171 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019311	protein coding gene	Chr11:129738146-129749320 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019885	protein coding gene	Chr11:120888152-120900896 (-)
PWK/PhJ	MGP_PWKPhJ_G0018523	protein coding gene	Chr11:117443397-117454198 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018315	protein coding gene	Chr11:120619543-120629857 (-)
WSB/EiJ	MGP_WSBEiJ_G0018809	protein coding gene	Chr11:120855104-120866674 (-)

Human Ortholog

TK1, thymidine kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TK1, thymidine kinase 1
Synonyms

TK2
Links

HGNC:11830

NCBI Gene ID: 7083

neXtProt AC: NX_P04183

UniProt: P04183
Chr Location

17q25.3; chr17:78174079-78187233 (-) GRCh38

MGI Vertebrate Homology

Tk1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TK1
Gene Tree

Tk1

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Phenotype Summary

24 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

3
Gene trapped

11
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mice show partial postnatal lethality, poor fertility, hemosiderosis, lymphocyte and spleen anomalies, altered sublingual gland secretion, inflammation of the arteries, lung, liver and thyroid, abnormal spermatogenesis and glomerulosclerosis leading to kidney failure and premature death.

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

818
Tissues

106
cDNA Data

100
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tk1

ZFIN tk1

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All Sequences

59
RefSeq

9
UniProt

2
CCDS

CCDS25692.1

Ensembl

ENSMUSG00000025574 (Evidence)
NCBI Gene

21877

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025574	Ensembl Gene Model \| MGI Sequence Detail	10567	C57BL/6J	± kb
transcript	ENSMUST00000026661	Ensembl \| MGI Sequence Detail	1440	Not Applicable
polypeptide	ENSMUSP00000026661	Ensembl \| MGI Sequence Detail	233	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000024045 thymidine kinase

(term hierarchy)
EC

2.7.1.21
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001267 Thymidine kinase

IPR020633 Thymidine kinase, conserved site

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All nucleic 112

Genomic 5

cDNA 100

Primer pair 1

Other 6

Microarray probesets 4

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MGD-MRK-15121, MGD-MRK-15124, MGI:2444019

Summaries

All 90

Developmental Gene Expression 9

Gene Ontology 8

Phenotypes 19
Earliest

J:5857 McBreen P, et al., Synteny of the genes for thymidine kinase and galactokinase in the mouse and their assignment to mouse chromosome 11. Cytogenet Cell Genet. 1977;19(1):7-13
Latest

J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194

TSS for Tk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112047	Chr11:117718223-117718232 (-)	-1,310 bp
Tssr112046	Chr11:117716610-117716698 (-)	264 bp
Tssr112045	Chr11:117716593-117716602 (-)	320 bp
Tssr112044	Chr11:117709929-117709969 (-)	6,969 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24