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Cryga Gene Detail
Summary
  • Symbol
    Cryga
  • Name
    crystallin, gamma A
  • Synonyms
    Cryg-4, DGcry-4, Secc
  • Feature Type
    protein coding gene
  • IDs
    MGI:88521
    NCBI Gene: 12964
  • Member of
    Cryg cluster
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:65139552-65142532 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 32.84 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88521
 protein coding gene Chr1:65139548-65142532 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016105
 protein coding gene Chr1:65299728-65302114 (-)
A/J MGP_AJ_G0016088
 protein coding gene Chr1:62995414-62997800 (-)
AKR/J MGP_AKRJ_G0016045
 protein coding gene Chr1:64758045-64760599 (-)
BALB/cJ MGP_BALBcJ_G0016043
 protein coding gene Chr1:63090138-63093693 (-)
C3H/HeJ MGP_C3HHeJ_G0015874
 protein coding gene Chr1:65032605-65034991 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016496
 protein coding gene Chr1:67818143-67820707 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014217
 protein coding gene Chr1:59047938-59050372 (-)
CAST/EiJ MGP_CASTEiJ_G0015458
 protein coding gene Chr1:64303341-64305757 (-)
CBA/J MGP_CBAJ_G0015847
 protein coding gene Chr1:70022757-70025169 (-)
DBA/2J MGP_DBA2J_G0015948
 protein coding gene Chr1:62398852-62401264 (-)
FVB/NJ MGP_FVBNJ_G0015951
 protein coding gene Chr1:61669979-61672365 (-)
LP/J MGP_LPJ_G0016020
 protein coding gene Chr1:66196556-66198942 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015971
 protein coding gene Chr1:72883023-72885409 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016543
 protein coding gene Chr1:64744495-64746881 (-)
PWK/PhJ MGP_PWKPhJ_G0015244
 protein coding gene Chr1:61796154-61798574 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015024
 protein coding gene Chr1:64227278-64229710 (-)
WSB/EiJ MGP_WSBEiJ_G0015520
 protein coding gene Chr1:64455914-64458300 (-)



Homology
more
  • Human Ortholog
    CRYGA, crystallin gamma A
  • Vertebrate Orthologs
    12
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRYGA, crystallin gamma A
  • Synonyms
    CRYG1, CRYG5, CRY-g-A
  • Links
    NCBI Gene ID: 1418
    neXtProt AC: NX_P11844
    UniProt: P11844

  • Chr Location
    2q33.3; chr2:208160740-208163589 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cryga mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Heterozygotes for an ethylnitrosourea-induced replacement mutation exhibit a diffuse nuclear opacity of the lens.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    21
  • cDNA Data
    310
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12964 NCBI Gene Model | MGI Sequence Detail 2981 C57BL/6J ±  kb
    transcript NM_007774 RefSeq | MGI Sequence Detail 621 ZRU/MplStud  
    polypeptide P04345 UniProt | EBI | MGI Sequence Detail 174 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 317
      Genomic 1
      cDNA 311
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2173, MGD-MRK-2176, MGD-MRK-8839, MGI:3698029
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 23
      Diseases 1
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:290269 Garg A, et al., Etv transcription factors functionally diverge from their upstream FGF signaling in lens development. Elife. 2020 Feb 11;9:e51915
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory