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Wnt1 Gene Detail
Summary
  • Symbol
    Wnt1
  • Name
    wingless-type MMTV integration site family, member 1
  • Synonyms
    Int-1, Wnt-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98953
    NCBI Gene: 22408
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:98687738-98691711 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 54.65 cM, cytoband F1-F3
  • Mapping Data
    50 experiments
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98953
 protein coding gene Chr15:98687738-98691718 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022311
 protein coding gene Chr15:100550823-100554783 (+)
A/J MGP_AJ_G0022269
 protein coding gene Chr15:96578373-96582360 (+)
AKR/J MGP_AKRJ_G0022244
 protein coding gene Chr15:99551204-99555170 (+)
BALB/cJ MGP_BALBcJ_G0022276
 protein coding gene Chr15:96770789-96774755 (+)
C3H/HeJ MGP_C3HHeJ_G0022044
 protein coding gene Chr15:99603286-99607260 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022721
 protein coding gene Chr15:104292511-104296536 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020246
 protein coding gene Chr15:92494560-92498536 (+)
CAST/EiJ MGP_CASTEiJ_G0021567
 protein coding gene Chr15:100452972-100456922 (+)
CBA/J MGP_CBAJ_G0022013
 protein coding gene Chr15:107828297-107832263 (+)
DBA/2J MGP_DBA2J_G0022139
 protein coding gene Chr15:96022368-96026353 (+)
FVB/NJ MGP_FVBNJ_G0022119
 protein coding gene Chr15:94998836-95002813 (+)
LP/J MGP_LPJ_G0022211
 protein coding gene Chr15:100699399-100704745 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022139
 protein coding gene Chr15:111831208-111835183 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022736
 protein coding gene Chr15:99631697-99635676 (+)
PWK/PhJ MGP_PWKPhJ_G0021308
 protein coding gene Chr15:96144237-96148255 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021143
 protein coding gene Chr15:99481490-99485447 (+)
WSB/EiJ MGP_WSBEiJ_G0021617
 protein coding gene Chr15:100182402-100186384 (+)



Homology
more
  • Human Ortholog
    WNT1, Wnt family member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT1, Wnt family member 1
  • Synonyms
    BMND16, INT1, OI15
  • Links
    NCBI Gene ID: 7471
    neXtProt AC: NX_P04628
    UniProt: P04628

  • Chr Location
    12q13.12; chr12:48978322-48982620 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Wnt1 mouse models; 1 with human WNT1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 8 alleles in 13 genetic backgrounds
    55 phenotypes from multigenic genotypes
    208 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
In mild form, homozygotes have ataxia and hypertonia, with malformation of anterior cerebellum, deep midline fissure, and impaired fertility. In the severe form, there is virtually no midbrain and cerebellum and mutants die within hours of birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    121
  • GO References
    58
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1926
  • Tissues
    485
  • cDNA Data
    42
  • Literature Summary
    352
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22408 NCBI Gene Model | MGI Sequence Detail 3974 C57BL/6J ±  kb
    transcript NM_021279 RefSeq | MGI Sequence Detail 2371 ZRU/MplStud  
    polypeptide P04426 UniProt | EBI | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      Genomic 11
      cDNA 48
      Primer pair 20
      Other 61

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11418, MGD-MRK-14669, MGD-MRK-15438, MGD-MRK-15448
    References
    more
    • Summaries
      All 773
      Developmental Gene Expression 352
      Diseases 4
      Gene Ontology 58
      Phenotypes 208
    • Earliest
      J:6976 Nusse R, et al., Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell. 1982 Nov;31(1):99-109
    • Latest
      J:352711 Zhao R, et al., Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination. Elife. 2024 Jun 14;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory