Prkaca MGI Mouse Gene Detail - MGI:97592 - protein kinase, cAMP dependent, catalytic, alpha

Symbol

Prkaca
Name

protein kinase, cAMP dependent, catalytic, alpha
Synonyms

C alpha, Cs, PKA, Pkaca

Feature Type

protein coding gene
IDs

MGI:97592
NCBI Gene: 18747
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr8:84699622-84723072 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 40.22 cM, cytoband C3
Mapping Data

1 experiment

SNPs within 2kb

456 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97592	protein coding gene	Chr8:84699607-84723073 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033844	protein coding gene	Chr8:84833724-84858129 (+)
A/J	MGP_AJ_G0033827	protein coding gene	Chr8:81513238-81536514 (+)
AKR/J	MGP_AKRJ_G0033753	protein coding gene	Chr8:83918480-83946803 (+)
BALB/cJ	MGP_BALBcJ_G0033820	protein coding gene	Chr8:81619461-81642570 (+)
C3H/HeJ	MGP_C3HHeJ_G0033530	protein coding gene	Chr8:84531531-84554710 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034340	protein coding gene	Chr8:88074941-88104283 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031282	protein coding gene	Chr8:75313946-75337298 (+)
CAST/EiJ	MGP_CASTEiJ_G0032860	protein coding gene	Chr8:83945392-83971854 (+)
CBA/J	MGP_CBAJ_G0033506	protein coding gene	Chr8:91207733-91231500 (+)
DBA/2J	MGP_DBA2J_G0033661	protein coding gene	Chr8:81150654-81173587 (+)
FVB/NJ	MGP_FVBNJ_G0033607	protein coding gene	Chr8:80072645-80096297 (+)
LP/J	MGP_LPJ_G0033751	protein coding gene	Chr8:84948350-84972806 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033649	protein coding gene	Chr8:93709946-93734471 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034357	protein coding gene	Chr8:83896358-83920637 (+)
PWK/PhJ	MGP_PWKPhJ_G0032564	protein coding gene	Chr8:80371623-80395579 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032401	protein coding gene	Chr8:82710178-82733280 (+)
WSB/EiJ	MGP_WSBEiJ_G0032973	protein coding gene	Chr8:84306768-84333616 (+)

Human Ortholog

PRKACA, protein kinase cAMP-activated catalytic subunit alpha

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRKACA, protein kinase cAMP-activated catalytic subunit alpha
Synonyms

CAFD1, PKACA, PPNAD4
Links

HGNC:9380

NCBI Gene ID: 5566

neXtProt AC: NX_P17612

UniProt: P17612
Chr Location

19p13.12; chr19:14091688-14118084 (-) GRCh38

MGI Vertebrate Homology

Prkaca stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PRKACA
Gene Tree

Prkaca

Diseases

4 with human PRKACA associations

				Human Disease	Mouse Models
				adrenal cortical adenoma IDs adrenal cortical adenoma DOID:0050891
				congestive heart failure IDs congestive heart failure DOID:6000 DOID:395 ICD10CM:I50 ICD10CM:I50.9 ICD9CM:428 ICD9CM:428.0 ICD9CM:428.9 MESH:D006333 NCI:C3080 NCI:C50577 UMLS_CUI:C0018801 UMLS_CUI:C0018802
				fibrolamellar carcinoma IDs fibrolamellar carcinoma DOID:5015 MESH:C537258 NCI:C4131 ORDO:401920 UMLS_CUI:C0334287
				primary pigmented nodular adrenocortical disease 4 IDs primary pigmented nodular adrenocortical disease 4 DOID:0070549 OMIM:615830

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

27 phenotypes from 4 alleles in 3 genetic backgrounds
24 phenotypes from multigenic genotypes
2 images
68 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

1
Targeted

4
Transgenic

1
Genomic Mutations

2 involving Prkaca
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice are highly susceptible to perinatal lethality. Surviving mice are runted and while spermatogenesis progresses normally, mature sperm shows impaired motility.

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All GO Annotations

137
GO References

58

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1027
Tissues

228
cDNA Data

126
Literature Summary

23

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prkaca

ZFIN prkacaa, prkacab

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All Sequences

57
RefSeq

4
UniProt

2
CCDS

CCDS22463.1, CCDS85574.1

Ensembl

ENSMUSG00000005469 (Evidence)
NCBI Gene

18747

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005469	Ensembl Gene Model \| MGI Sequence Detail	23451	C57BL/6J	± kb
transcript	ENSMUST00000005606	Ensembl \| MGI Sequence Detail	2276	Not Applicable
polypeptide	ENSMUSP00000005606	Ensembl \| MGI Sequence Detail	351	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013222 cAMP-dependent protein kinase catalytic subunit alpha

(term hierarchy)
PDB

1APM, 1ATP, 1BKX, 1BX6, 1FMO, 1J3H, 1JBP, 1JLU, 1L3R, 1RDQ, 1RE8, 1REJ, 1REK, 1SYK, 2CPK, 2ERZ, 2QCS, 2QUR, 2QVS, 3FHI, 3FJQ, 3IDB, 3IDC, 3J4Q, 3J4R, 3O7L, 3OW3, 3PVB, 3QAL, 3QAM, 3TNP, 3TNQ, 3X2U, 3X2V, 3X2W, 4DFX, 4DFY, 4DFZ, 4DG0, 4DG2, 4DG3, 4DH1, 4DH3, 4DH5, 4DH7, 4DH8, 4DIN, 4HPT, 4HPU, 4IAC, 4IAD, 4IAF, 4IAI, 4IAK, 4IAY, 4IAZ, 4IB0, 4IB1, 4IB3, 4NTS, 4NTT, 4O21, 4O22, 4WBB, 4X6Q, 4X6R, 4XW4, 4XW5, 4XW6, 5JR7, 5X3F, 6E21, 6MM5, 6MM6, 6MM7, 6MM8, 7E0Z, 7E11, 7E12, 7UJX, 7V0G
EC

2.7.11.11
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR044109 cAMP-dependent protein kinase catalytic subunit

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

P05132 1 site, 1 O-linked glycan (1 site)

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All nucleic 133

Genomic 3

cDNA 126

Primer pair 4

Microarray probesets 6

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MGD-MRK-13323

Summaries

All 264

Developmental Gene Expression 23

Diseases 1

Gene Ontology 58

Phenotypes 68
Earliest

J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
Latest

J:348117 Okuma H, et al., N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on alpha-dystroglycan and prevents muscular dystrophy. Elife. 2023 Feb 1;12

TSS for Prkaca:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78314	Chr8:84699580-84699657 (+)	-3 bp
Tssr78315	Chr8:84699677-84699688 (+)	61 bp
Tssr78316	Chr8:84703492-84703493 (+)	3,871 bp
Tssr78317	Chr8:84703495-84703507 (+)	3,879 bp
Tssr78318	Chr8:84703508-84703528 (+)	3,896 bp
Tssr78319	Chr8:84703674-84703690 (+)	4,060 bp
Tssr78320	Chr8:84705053-84705090 (+)	5,450 bp
Tssr78321	Chr8:84707141-84707181 (+)	7,539 bp
Tssr78322	Chr8:84709424-84709432 (+)	9,806 bp
Tssr78323	Chr8:84716094-84716108 (+)	16,479 bp
Tssr78324	Chr8:84716159-84716178 (+)	16,547 bp
Tssr78325	Chr8:84716183-84716204 (+)	16,572 bp
Tssr78326	Chr8:84722042-84722059 (+)	22,429 bp
Tssr78327	Chr8:84722102-84722109 (+)	22,484 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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