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Myb Gene Detail
Summary
  • Symbol
    Myb
  • Name
    myeloblastosis oncogene
  • Synonyms
    c-myb
  • Feature Type
    protein coding gene
  • IDs
    MGI:97249
    NCBI Gene: 17863
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:21000834-21036883 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 9.75 cM
  • Mapping Data
    67 experiments
Strain
Comparison
more
  • SNPs within 2kb
    953 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    22
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97249
 protein coding gene Chr10:21000829-21036883 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017058
 protein coding gene Chr10:18917275-18957157 (-)
A/J MGP_AJ_G0017036
 protein coding gene Chr10:18187723-18224746 (-)
AKR/J MGP_AKRJ_G0017000
 protein coding gene Chr10:18512097-18550190 (-)
BALB/cJ MGP_BALBcJ_G0016994
 protein coding gene Chr10:18254273-18290836 (-)
C3H/HeJ MGP_C3HHeJ_G0016819
 protein coding gene Chr10:18837657-18878277 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017456
 protein coding gene Chr10:19397333-19435108 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015161
 protein coding gene Chr10:17167621-17204128 (-)
CAST/EiJ MGP_CASTEiJ_G0016401
 protein coding gene Chr10:18757284-18796839 (-)
CBA/J MGP_CBAJ_G0016791
 protein coding gene Chr10:20268370-20315244 (-)
DBA/2J MGP_DBA2J_G0016899
 protein coding gene Chr10:18067357-18103848 (-)
FVB/NJ MGP_FVBNJ_G0016894
 protein coding gene Chr10:17811315-17848080 (-)
LP/J MGP_LPJ_G0016974
 protein coding gene Chr10:18713762-18752757 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016924
 protein coding gene Chr10:20494833-20535191 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017494
 protein coding gene Chr10:18501122-18538140 (-)
PWK/PhJ MGP_PWKPhJ_G0016186
 protein coding gene Chr10:17969166-18006229 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015969
 protein coding gene Chr10:18672377-18711903 (-)
WSB/EiJ MGP_WSBEiJ_G0016463
 protein coding gene Chr10:18594989-18637502 (-)



Homology
more
  • Human Ortholog
    MYB, MYB proto-oncogene, transcription factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYB, MYB proto-oncogene, transcription factor
  • Synonyms
    c-myb, Cmyb, c-myb_CDS, efg
  • Links
    NCBI Gene ID: 4602
    neXtProt AC: NX_P10242
    UniProt: P10242

  • Chr Location
    6q23.3; chr6:135181308-135219173 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Myb mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    74 phenotypes from 11 alleles in 12 genetic backgrounds
    32 phenotypes from multigenic genotypes
    96 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for deficient alleles of this gene display severe hematopoietic abnormalities. Red and white blood cells and platelets are all affected.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1330
  • Tissues
    323
  • cDNA Data
    30
  • Literature Summary
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019982 Ensembl Gene Model | MGI Sequence Detail 36050 C57BL/6J ±  kb
    transcript ENSMUST00000188495 Ensembl | MGI Sequence Detail 3693 Not Applicable  
    polypeptide ENSMUSP00000139699 Ensembl | MGI Sequence Detail 755 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      Genomic 16
      cDNA 32
      Primer pair 12
      Other 9

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12735, MGI:2143640, MGI:2143955
    References
    more
    • Summaries
      All 313
      Developmental Gene Expression 51
      Diseases 1
      Gene Ontology 21
      Phenotypes 96
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:353453 Simats A, et al., Innate immune memory after brain injury drives inflammatory cardiac dysfunction. Cell. 2024 Jul 12;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory