Ifna6 MGI Mouse Gene Detail - MGI:107662

Symbol

Ifna6
Name

interferon alpha 6
Synonyms

Ifa6, Ifna8

Feature Type

protein coding gene
IDs

MGI:107662
NCBI Gene: 15969
Member of

Ifna cluster
Alliance

gene page

Sequence Map

Chr4:88745653-88746222 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 42.03 cM
Mapping Data

5 experiments

SNPs within 2kb

164 from dbSNP Build 142
Strain Annotations

10
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107662	protein coding gene	Chr4:88745627-88746269 (+)
129S1/SvImJ	no annotation
A/J	MGP_AJ_G0028398	protein coding gene	Chr4:85632123-85632805 (+)
AKR/J	MGP_AKRJ_G0028345	protein coding gene	Chr4:87753847-87754489 (+)
BALB/cJ	MGP_BALBcJ_G0028416	protein coding gene	Chr4:85853535-85854177 (+)
C3H/HeJ	MGP_C3HHeJ_G0028129	protein coding gene	Chr4:88468245-88468907 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028855	protein coding gene	Chr4:92116245-92116814 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0028099	protein coding gene	Chr4:94966870-94967482 (+)
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0028215	protein coding gene	Chr4:84322005-84322574 (+)
LP/J	no annotation
NOD/ShiLtJ	MGP_NODShiLtJ_G0028245	protein coding gene	Chr4:99943766-99944335 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028892	protein coding gene	Chr4:87887069-87887638 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

IFNA1, interferon alpha 1

Vertebrate Orthologs

21

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IFNA1, interferon alpha 1
Synonyms

IFL, IFN, IFNA@, IFNA13, IFN-ALPHA, IFN-alphaD, leIF D
Links

HGNC:5417

NCBI Gene ID: 3439

neXtProt AC: NX_P01562

UniProt: P01562
Chr Location

9p21.3; chr9:21440439-21441316 (+) GRCh38

Human Ortholog

IFNA10, interferon alpha 10
Synonyms

IFN-alphaC
Links

HGNC:5418

NCBI Gene ID: 3446

neXtProt AC: NX_P01566

UniProt: P01566
Chr Location

9p21.3; chr9:21206181-21207143 (-) GRCh38

Human Ortholog

IFNA13, interferon alpha 13
Links

HGNC:5419

NCBI Gene ID: 3447

neXtProt AC: NX_P01562

UniProt: P01562
Chr Location

9p21.3; chr9:21367372-21368057 (-) GRCh38

Human Ortholog

IFNA14, interferon alpha 14
Synonyms

IFN-alphaH, LEIF2H
Links

HGNC:5420

NCBI Gene ID: 3448

neXtProt AC: NX_P01570

UniProt: P01570
Chr Location

9p21.3; chr9:21239002-21240005 (-) GRCh38

Human Ortholog

IFNA16, interferon alpha 16
Synonyms

IFN-alpha-16, IFN-alphaO
Links

HGNC:5421

NCBI Gene ID: 3449

neXtProt AC: NX_P05015

UniProt: P05015
Chr Location

9p21.3; chr9:21216373-21217311 (-) GRCh38

Human Ortholog

IFNA17, interferon alpha 17
Synonyms

IFNA, IFN-alphaI, INFA, LEIF2C1
Links

HGNC:5422

NCBI Gene ID: 3451

neXtProt AC: NX_P01571

UniProt: P01571
Chr Location

9p21.3; chr9:21227243-21228222 (-) GRCh38

Human Ortholog

IFNA2, interferon alpha 2
Synonyms

IFNA, IFNA2B, IFN-alpha-2, IFN-alphaA, leIF A
Links

HGNC:5423

NCBI Gene ID: 3440

neXtProt AC: NX_P01563

UniProt: P01563
Chr Location

9p21.3; chr9:21384255-21385398 (-) GRCh38

Human Ortholog

IFNA21, interferon alpha 21
Synonyms

IFN-alphaI, leIF-F, LeIF F
Links

HGNC:5424

NCBI Gene ID: 3452

neXtProt AC: NX_P01568

UniProt: P01568
Chr Location

9p21.3; chr9:21165637-21166660 (-) GRCh38

Human Ortholog

IFNA4, interferon alpha 4
Synonyms

IFN-alpha4a, INFA4
Links

HGNC:5425

NCBI Gene ID: 3441

neXtProt AC: NX_P05014

UniProt: P05014
Chr Location

9p21.3; chr9:21186618-21187587 (-) GRCh38

Human Ortholog

IFNA5, interferon alpha 5
Synonyms

IFN-alpha-5, IFN-alphaG, INA5, INFA5, leIF G
Links

HGNC:5426

NCBI Gene ID: 3442

neXtProt AC: NX_P01569

UniProt: P01569
Chr Location

9p21.3; chr9:21304326-21305313 (-) GRCh38

Human Ortholog

IFNA6, interferon alpha 6
Synonyms

IFN-alphaK
Links

HGNC:5427

NCBI Gene ID: 3443

neXtProt AC: NX_P05013

UniProt: P05013
Chr Location

9p21.3; chr9:21350253-21350956 (-) GRCh38

Human Ortholog

IFNA7, interferon alpha 7
Synonyms

IFNA-J, IFN-alphaJ
Links

HGNC:5428

NCBI Gene ID: 3444

neXtProt AC: NX_P01567

UniProt: P01567
Chr Location

9p21.3; chr9:21201469-21202205 (-) GRCh38

Human Ortholog

IFNA8, interferon alpha 8
Synonyms

IFN-alphaB
Links

HGNC:5429

NCBI Gene ID: 3445

neXtProt AC: NX_P32881

UniProt: P32881
Chr Location

9p21.3; chr9:21409117-21410185 (+) GRCh38

MGI Vertebrate Homology

Ifna6 stringent orthology
13 human;1 mouse;6 rat;2 zebrafish
HCOP

vertebrate homology predictions: IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8
Gene Tree

Ifna6

Diseases

6 with human IFNA1,IFNA17,IFNA2 associations

				Human Disease	Mouse Models
				common cold IDs common cold DOID:10459 ICD10CM:J00 ICD9CM_2006:460 ICD9CM:460 MESH:D003139 NCI:C34500 UMLS_CUI:C0009443
				Crimean-Congo hemorrhagic fever IDs Crimean-Congo hemorrhagic fever DOID:12287 ICD10CM:A98.0 ICD9CM:065.0 ICD9CM_2006:065.0 MESH:D006479 NCI:C34682 UMLS_CUI:C0019099
				hepatitis B IDs hepatitis B DOID:2043 DOID:12591 DOID:12592 DOID:2042 EFO:0004197 MESH:D006509 NCI:C3097 UMLS_CUI:C0019163
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				liver cirrhosis IDs liver cirrhosis DOID:5082 EFO:0001422 ICD10CM:K74.60 MESH:D008103 NCI:C2951 UMLS_CUI:C0023890
				sarcoidosis IDs sarcoidosis DOID:11335 ICD10CM:D86 ICD9CM:135 MESH:D012507 NCI:C34995 ORDO:797 UMLS_CUI:C0036202

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
5 phenotypes from multigenic genotypes
12 phenotype references

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

3
Radiation induced

1
Targeted

1
Genomic Mutations

5 involving Ifna6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

Mice heterozygous for reporter allele are viable and fertile, and show normal production of interferon-alpha in response to viral infection.

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

4

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

23
RefSeq

2
UniProt

3
CCDS

CCDS38811.1

Ensembl

ENSMUSG00000101252 (Evidence)
NCBI Gene

15969

			Length	Strain/Species	Flank
genomic	ENSMUSG00000101252	Ensembl Gene Model \| MGI Sequence Detail	570	C57BL/6J	± kb
transcript	ENSMUST00000105146	Ensembl \| MGI Sequence Detail	570	Not Applicable
polypeptide	ENSMUSP00000100777	Ensembl \| MGI Sequence Detail	189	Not Applicable

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UniProt

3 Sequences
InterPro Domains

IPR009079 Four-helical cytokine-like, core

IPR000471 Interferon alpha/beta/delta
GlyGen

P07350 1 site

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All nucleic 12

Genomic 6

cDNA 4

Primer pair 1

Other 1

Microarray probesets 3

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MGD-MRK-11207, MGD-MRK-11209, MGD-MRK-36235, MGD-MRK-36237, MGI:107660

Summaries

All 40

Gene Ontology 6

Phenotypes 12
Earliest

J:7878 Zwarthoff EC, et al., Organization, structure and expression of murine interferon alpha genes. Nucleic Acids Res. 1985 Feb 11;13(3):791-804
Latest

J:324389 Paulsen M, et al., MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice. Front Immunol. 2020;11:572747

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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