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Fcgr2b Gene Detail
Summary
  • Symbol
    Fcgr2b
  • Name
    Fc receptor, IgG, low affinity IIb
  • Synonyms
    CD32, F630109E10Rik, Fc gamma RIIB, FcgammaRIIB, Fcgr2, Fcgr2a, Fc[g]RII, FcgRII, Fcr-2, Fcr-3, Ly-17, LyM-1, Ly-m20
  • Feature Type
    protein coding gene
  • IDs
    MGI:95499
    NCBI Gene: 14130
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:170786186-170804116 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 78.02 cM
  • Mapping Data
    75 experiments
Strain
Comparison
more
  • SNPs within 2kb
    655 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95499
 protein coding gene Chr1:170786186-170804141 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016738
 protein coding gene Chr1:176705571-176728687 (-)
A/J MGP_AJ_G0016718
 protein coding gene Chr1:169500102-169518087 (-)
AKR/J MGP_AKRJ_G0016684
 protein coding gene Chr1:174593786-174612816 (-)
BALB/cJ MGP_BALBcJ_G0016679
 protein coding gene Chr1:169974583-169992885 (-)
C3H/HeJ MGP_C3HHeJ_G0016502
 protein coding gene Chr1:174828448-174845494 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017140
 protein coding gene Chr1:182563068-182581438 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014849
 protein coding gene Chr1:161211144-161229017 (-)
CAST/EiJ MGP_CASTEiJ_G0016083
 protein coding gene Chr1:174462601-174480771 (-)
CBA/J MGP_CBAJ_G0016477
 protein coding gene Chr1:189049117-189070734 (-)
DBA/2J MGP_DBA2J_G0016584
 protein coding gene Chr1:168349656-168367485 (-)
FVB/NJ MGP_FVBNJ_G0016580
 protein coding gene Chr1:166709842-166727009 (-)
LP/J MGP_LPJ_G0016655
 protein coding gene Chr1:177825833-177845880 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016607
 protein coding gene Chr1:196353339-196372360 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017177
 protein coding gene Chr1:174475791-174494629 (-)
PWK/PhJ MGP_PWKPhJ_G0015869
 protein coding gene Chr1:167592877-167610675 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015653
 protein coding gene Chr1:173228211-173244562 (-)
WSB/EiJ MGP_WSBEiJ_G0016145
 protein coding gene Chr1:174597644-174617537 (-)



Homology
more
  • Human Ortholog
    FCGR2A, Fc gamma receptor IIa
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FCGR2A, Fc gamma receptor IIa
  • Synonyms
    CD32, CD32A, CDw32, FCG2, FcgammaRIIa, FcGR, FCGR2, FCGR2A1, IGFR2
  • Links
    NCBI Gene ID: 2212
    neXtProt AC: NX_P12318
    UniProt: P12318

  • Chr Location
    1q23.3; chr1:161505430-161524048 (+)  GRCh38
  • Human Ortholog
    FCGR2B, Fc gamma receptor IIb
  • Synonyms
    CD32, CD32B, FCG2, FcgammaRIIb, FCGR2, FCGR2C, FcGRIIB, FcRII-c, IGFR2
  • Links
    NCBI Gene ID: 2213
    neXtProt AC: NX_P31994
    UniProt: P31994

  • Chr Location
    1q23.3; chr1:161647243-161678654 (+)  GRCh38
  • Human Ortholog
    FCGR2C, Fc gamma receptor IIc (gene/pseudogene)
  • Synonyms
    CD32, CD32C, CDW32, FCG2, FcgammaRIIc, FCRIIC, IGFR2
  • Links
    NCBI Gene ID: 9103
    neXtProt AC: NX_P31995
    UniProt: P31995

  • Chr Location
    1q23.3; chr1:161581339-161605662 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Fcgr2b mouse models; 32 with human FCGR2A,FCGR2B associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
      
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 4 alleles in 6 genetic backgrounds
    50 phenotypes from multigenic genotypes
    1 images
    308 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutants show increased antibody response, passive cutaneous analphylaxis, autoantibodies and arthritis susceptibility. On C57BL/6, mice die by 9 months with anemia, proteinuria, glomerulonephritis, and inflammatory disease. A strain variant controls expression in germinal center B cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    68
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    13
  • cDNA Data
    53
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026656 Ensembl Gene Model | MGI Sequence Detail 17931 C57BL/6J ±  kb
    transcript ENSMUST00000027966 Ensembl | MGI Sequence Detail 3544 Not Applicable  
    polypeptide ENSMUSP00000027966 Ensembl | MGI Sequence Detail 340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      Genomic 6
      cDNA 57
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11955, MGD-MRK-12013, MGD-MRK-12069, MGD-MRK-12070, MGD-MRK-9733, MGD-MRK-9734, MGD-MRK-9735, MGD-MRK-9739, MGD-MRK-9740, MGI:2138286, MGI:2445072
    References
    more
    • Summaries
      All 472
      Developmental Gene Expression 6
      Diseases 4
      Gene Ontology 17
      Phenotypes 308
    • Earliest
      J:5896 Dickler HB, et al., B-lymphocyte Fc receptor-associated non-H-2 antigens are determined by a single polymorphic locus which is linked to the Mls locus. J Exp Med. 1977 Dec 1;146(6):1678-92
    • Latest
      J:354496 Stark K, et al., Antibodies and complement are key drivers of thrombosis. Immunity. 2024 Sep 10;57(9):2140-2156.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory