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Camk4 Gene Detail
Summary
  • Symbol
    Camk4
  • Name
    calcium/calmodulin-dependent protein kinase IV
  • Synonyms
    A430110E23Rik, Ca2+/calmodulin-dependent protein kinase type IV/Gr, CaMKIV, CaMKIV/Gr, D18Bwg0362e
  • Feature Type
    protein coding gene
  • IDs
    MGI:88258
    NCBI Gene: 12326
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:33067984-33324281 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 18.15 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6409 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88258
 protein coding gene Chr18:33067984-33328820 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024231
 protein coding gene Chr18:31113442-31361565 (+)
A/J MGP_AJ_G0024197
 protein coding gene Chr18:30072959-30308350 (+)
AKR/J MGP_AKRJ_G0024166
 protein coding gene Chr18:30898747-31137682 (+)
BALB/cJ MGP_BALBcJ_G0024197
 protein coding gene Chr18:30148438-30379260 (+)
C3H/HeJ MGP_C3HHeJ_G0023965
 protein coding gene Chr18:30960547-31196911 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024639
 protein coding gene Chr18:32222749-32518761 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022080
 protein coding gene Chr18:30281576-30508125 (+)
CAST/EiJ MGP_CASTEiJ_G0023440
 protein coding gene Chr18:30834611-31079174 (+)
CBA/J MGP_CBAJ_G0023933
 protein coding gene Chr18:33212680-33460787 (+)
DBA/2J MGP_DBA2J_G0024065
 protein coding gene Chr18:29748920-29983026 (+)
FVB/NJ MGP_FVBNJ_G0024031
 protein coding gene Chr18:29447815-29680241 (+)
LP/J MGP_LPJ_G0024146
 protein coding gene Chr18:31179573-31426432 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024059
 protein coding gene Chr18:34519565-34781015 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024687
 protein coding gene Chr18:30745788-30996054 (+)
PWK/PhJ MGP_PWKPhJ_G0023183
 protein coding gene Chr18:29907526-30149453 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022992
 protein coding gene Chr18:31015758-31241642 (+)
WSB/EiJ MGP_WSBEiJ_G0023503
 protein coding gene Chr18:30665771-30901886 (+)



Homology
more
  • Human Ortholog
    CAMK4, calcium/calmodulin dependent protein kinase IV
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAMK4, calcium/calmodulin dependent protein kinase IV
  • Synonyms
    caMK, CaMK-GR, CaMK IV, CaMKIV
  • Links
    NCBI Gene ID: 814
    neXtProt AC: NX_Q16566
    UniProt: Q16566

  • Chr Location
    5q22.1; chr5:111223583-111494886 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CAMK4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    67 phenotypes from 6 alleles in 6 genetic backgrounds
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for different targeted mutations show variable phenotypes, including reduced viability, male and/or female sterility, and mild to severe neurological and spatial memory disorders.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    74
  • cDNA Data
    17
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038128 Ensembl Gene Model | MGI Sequence Detail 256298 C57BL/6J ±  kb
    transcript ENSMUST00000042868 Ensembl | MGI Sequence Detail 2717 Not Applicable  
    polypeptide ENSMUSP00000046539 Ensembl | MGI Sequence Detail 469 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 2
      cDNA 17
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1745, MGD-MRK-33961, MGI:106269, MGI:2147260, MGI:3026992
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 12
      Gene Ontology 11
      Phenotypes 45
    • Earliest
      J:32614 Sikela JM, et al., Screening an expression library with a ligand probe: isolation and sequence of a cDNA corresponding to a brain calmodulin-binding protein. Proc Natl Acad Sci U S A. 1987 May;84(9):3038-42
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory