About   Help   FAQ
Gnai2 Gene Detail
Summary
  • Symbol
    Gnai2
  • Name
    G protein subunit alpha i2
  • Synonyms
    Galphai2, Gia, Gnai-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95772
    NCBI Gene: 14678
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107491324-107512542 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.43 cM
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    521 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95772
 protein coding gene Chr9:107491324-107512566 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035265
 protein coding gene Chr9:109502995-109524725 (-)
A/J MGP_AJ_G0035244
 protein coding gene Chr9:105512032-105533528 (-)
AKR/J MGP_AKRJ_G0035176
 protein coding gene Chr9:108146396-108167905 (-)
BALB/cJ MGP_BALBcJ_G0035238
 protein coding gene Chr9:105180558-105202371 (-)
C3H/HeJ MGP_C3HHeJ_G0034948
 protein coding gene Chr9:108543042-108566675 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035758
 protein coding gene Chr9:112482565-112505108 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032656
 protein coding gene Chr9:102940535-102962266 (-)
CAST/EiJ MGP_CASTEiJ_G0034259
 protein coding gene Chr9:108476830-108500308 (-)
CBA/J MGP_CBAJ_G0034916
 protein coding gene Chr9:116454827-116477062 (-)
DBA/2J MGP_DBA2J_G0035077
 protein coding gene Chr9:104964796-104985934 (-)
FVB/NJ MGP_FVBNJ_G0035025
 protein coding gene Chr9:103732002-103753538 (-)
LP/J MGP_LPJ_G0035153
 protein coding gene Chr9:109696604-109721247 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035064
 protein coding gene Chr9:118070422-118091855 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035779
 protein coding gene Chr9:108418939-108440444 (-)
PWK/PhJ MGP_PWKPhJ_G0033966
 protein coding gene Chr9:105285641-105307044 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033801
 protein coding gene Chr9:108470637-108491635 (-)
WSB/EiJ MGP_WSBEiJ_G0034380
 protein coding gene Chr9:108299032-108321261 (-)



Homology
more
  • Human Ortholog
    GNAI2, G protein subunit alpha i2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNAI2, G protein subunit alpha i2
  • Synonyms
    GIP, GNAI2B, HG1C, H_LUCA15.1, H_LUCA16.1
  • Links
    NCBI Gene ID: 2771
    neXtProt AC: NX_P04899
    UniProt: P04899

  • Chr Location
    3p21.31; chr3:50226292-50263358 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gnai2 mouse models

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    67 phenotypes from 5 alleles in 12 genetic backgrounds
    17 phenotypes from multigenic genotypes
    2 images
    123 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit growth retardation, lethal ulcerative colitis, colon adenocarcinomas, granulocytosis, altered thymocyte maturation and function and enhanced production of pro-inflammatory cytokines, and may show alterations in leukocyte physiology and susceptibility to parasitic infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1001
  • Tissues
    156
  • cDNA Data
    471
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14678 NCBI Gene Model | MGI Sequence Detail 21219 C57BL/6J ±  kb
    transcript NM_008138 RefSeq | MGI Sequence Detail 2227 ZRU/MplStud  
    polypeptide P08752 UniProt | EBI | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000008086 guanine nucleotide-binding protein G(i) subunit alpha-2
      (term hierarchy)
    • InterPro Domains
      IPR001408 G-protein alpha subunit, group I
      IPR011025 G protein alpha subunit, helical insertion
      IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      P08752 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 485
      Genomic 3
      cDNA 474
      Primer pair 4
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10075, MGD-MRK-10181, MGD-MRK-10184, MGI:2143377
    References
    more
    • Summaries
      All 229
      Developmental Gene Expression 31
      Diseases 3
      Gene Ontology 16
      Phenotypes 123
    • Earliest
      J:8410 Sullivan KA, et al., Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6687-91
    • Latest
      J:338698 Jarysta A, et al., Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis. Elife. 2024 Apr 23;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory