Hoxb3 MGI Mouse Gene Detail - MGI:96184

Symbol

Hoxb3
Name

homeobox B3
Synonyms

Hox-2.7

Feature Type

protein coding gene
IDs

MGI:96184
NCBI Gene: 15410
Member of

Hoxb cluster
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:96214152-96238756 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 59.84 cM
Mapping Data

4 experiments

SNPs within 2kb

386 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96184	protein coding gene	Chr11:96197927-96238756 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019007	protein coding gene	Chr11:98636481-98661028 (+)
A/J	MGP_AJ_G0018975	protein coding gene	Chr11:94607890-94632422 (+)
AKR/J	MGP_AKRJ_G0018945	protein coding gene	Chr11:97534088-97559194 (+)
BALB/cJ	MGP_BALBcJ_G0018948	protein coding gene	Chr11:95107602-95131900 (+)
C3H/HeJ	MGP_C3HHeJ_G0018762	protein coding gene	Chr11:97665332-97689839 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019400	protein coding gene	Chr11:101717463-101741975 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017030	protein coding gene	Chr11:92094449-92119230 (+)
CAST/EiJ	MGP_CASTEiJ_G0018315	protein coding gene	Chr11:98490779-98515376 (+)
CBA/J	MGP_CBAJ_G0018733	protein coding gene	Chr11:105879331-105906620 (+)
DBA/2J	MGP_DBA2J_G0018841	protein coding gene	Chr11:94175346-94199845 (+)
FVB/NJ	MGP_FVBNJ_G0018830	protein coding gene	Chr11:93654056-93678490 (+)
LP/J	MGP_LPJ_G0018911	protein coding gene	Chr11:99172528-99196941 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018857	protein coding gene	Chr11:105874853-105902041 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019440	protein coding gene	Chr11:97841531-97866001 (+)
PWK/PhJ	MGP_PWKPhJ_G0018087	protein coding gene	Chr11:95126978-95151890 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017876	protein coding gene	Chr11:97568889-97593572 (+)
WSB/EiJ	MGP_WSBEiJ_G0018365	protein coding gene	Chr11:97729792-97755961 (+)

Human Ortholog

HOXB3, homeobox B3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HOXB3, homeobox B3
Synonyms

HOX2, Hox-2.7, HOX2G
Links

HGNC:5114

NCBI Gene ID: 3213

neXtProt AC: NX_P14651

UniProt: P14651
Chr Location

17q21.32; chr17:48548870-48604912 (-) GRCh38

MGI Vertebrate Homology

Hoxb3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HOXB3
Gene Tree

Hoxb3

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
32 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Targeted

7
Genomic Mutations

4 involving Hoxb3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele display partial neonatal lethality and mild and low penetrance defects in the formation of the anterior arch of the atlas and the IXth cranial nerve.

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All GO Annotations

47
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1147
Tissues

214
cDNA Data

21
Literature Summary

72

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HOXB3

Xenbase hoxb3

ZFIN hoxb3a

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All Sequences

57
RefSeq

22
UniProt

2
CCDS

CCDS25299.1

Ensembl

ENSMUSG00000048763 (Evidence)
NCBI Gene

15410

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048763	Ensembl Gene Model \| MGI Sequence Detail	24605	C57BL/6J	± kb
transcript	ENSMUST00000093944	Ensembl \| MGI Sequence Detail	3190	Not Applicable
polypeptide	ENSMUSP00000091476	Ensembl \| MGI Sequence Detail	433	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008700 homeobox protein Hox-B3

(term hierarchy)
InterPro Domains

IPR025281 Domain of unknown function DUF4074

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

IPR001827 Homeobox protein, antennapedia type, conserved site

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All nucleic 57

Genomic 7

cDNA 23

Primer pair 9

Other 18

Microarray probesets 3

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MGD-MRK-10835, MGD-MRK-10885

Summaries

All 124

Developmental Gene Expression 72

Gene Ontology 9

Phenotypes 22
Earliest

J:8920 Lonai P, et al., New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409-18
Latest

J:334461 De Bono C, et al., Single-cell transcriptomics uncovers a non-autonomous Tbx1-dependent genetic program controlling cardiac neural crest cell development. Nat Commun. 2023 Mar 21;14(1):1551

TSS for Hoxb3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104514	Chr11:96214079-96214081 (+)	-72 bp
Tssr104515	Chr11:96223259-96223283 (+)	9,119 bp
Tssr104516	Chr11:96223367-96223372 (+)	9,218 bp
Tssr104517	Chr11:96223643-96223666 (+)	9,503 bp
Tssr104518	Chr11:96231629-96231639 (+)	17,482 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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