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Lta Gene Detail
Summary
  • Symbol
    Lta
  • Name
    lymphotoxin A
  • Synonyms
    hlb382, LT, LT-[a], LT[a], LT-alpha, LTalpha, Ltx, lymphotoxin, lymphotoxin alpha, Tnfb, TNF beta, TNF-beta, Tnfsf1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:104797
    NCBI Gene: 16992
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35422141-35424327 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.59 cM
  • Mapping Data
    28 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • PCR
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104797
 protein coding gene Chr17:35422141-35424568 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023629
 protein coding gene Chr17:35353040-35355172 (-)
A/J MGP_AJ_G0023588
 protein coding gene Chr17:34173495-34175625 (-)
AKR/J MGP_AKRJ_G0023557
 protein coding gene Chr17:34654457-34656591 (-)
BALB/cJ MGP_BALBcJ_G0023595
 protein coding gene Chr17:34317769-34319917 (-)
C3H/HeJ MGP_C3HHeJ_G0023356
 protein coding gene Chr17:35059789-35061949 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024034
 protein coding gene Chr17:36697569-36699701 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021515
 protein coding gene Chr17:31945003-31946500 (-)
CAST/EiJ MGP_CASTEiJ_G0022852
 protein coding gene Chr17:35062105-35064221 (-)
CBA/J MGP_CBAJ_G0023334
 protein coding gene Chr17:38210274-38212418 (-)
DBA/2J MGP_DBA2J_G0023462
 protein coding gene Chr17:33500837-33502983 (-)
FVB/NJ MGP_FVBNJ_G0023429
 protein coding gene Chr17:33342544-33344682 (-)
LP/J MGP_LPJ_G0023539
 protein coding gene Chr17:35681748-35683862 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023451
 protein coding gene Chr17:37138473-37140625 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024079
 protein coding gene Chr17:34883068-34885214 (-)
PWK/PhJ MGP_PWKPhJ_G0022600
 protein coding gene Chr17:32338163-32340364 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022420
 protein coding gene Chr17:32890239-32892380 (-)
WSB/EiJ MGP_WSBEiJ_G0022916
 protein coding gene Chr17:35006242-35008363 (-)



Homology
more
  • Human Ortholog
    LTA, lymphotoxin alpha
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LTA, lymphotoxin alpha
  • Synonyms
    LT, TNFB, TNFSF1, TNLG1E
  • Links
    NCBI Gene ID: 4049
    neXtProt AC: NX_P01374
    UniProt: P01374

  • Chr Location
    6p21.33; chr6:31560610-31574324 (+)  GRCh38
Human Diseases
more
  • Diseases
    32 with human LTA associations

Human Disease Mouse Models
      
IDs
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    92 phenotypes from 11 alleles in 23 genetic backgrounds
    13 phenotypes from multigenic genotypes
    2 images
    299 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit absence of lymph nodes, Peyer's patches, and splenic germinal centers, impaired class switching and NK cell recruitment, and greater susceptibility to Mycobacterium bovis, influenza A, and Toxoplasma gondii.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    35
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    59
  • cDNA Data
    8
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024402 Ensembl Gene Model | MGI Sequence Detail 2187 C57BL/6J ±  kb
    transcript ENSMUST00000025266 Ensembl | MGI Sequence Detail 1383 Not Applicable  
    polypeptide ENSMUSP00000025266 Ensembl | MGI Sequence Detail 202 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      Genomic 42
      cDNA 8
      Primer pair 8
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11928, MGD-MRK-15153, MGD-MRK-28089, MGI:3575121
    References
    more
    • Summaries
      All 418
      Developmental Gene Expression 12
      Gene Ontology 15
      Phenotypes 299
    • Earliest
      J:30783 Shacks SJ, et al., Studies on in vitro models of cellular immunity: the role of T and B cells in the secretion of lymphotoxin. Cell Immunol. 1973 May;7(2):313-21
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory