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Pgk1 Gene Detail
Summary
  • Symbol
    Pgk1
  • Name
    phosphoglycerate kinase 1
  • Synonyms
    Pgk-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97555
    NCBI Gene: 18655
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:105230706-105247305 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 47.36 cM, cytoband C-D
  • Mapping Data
    62 experiments
Strain
Comparison
more
  • SNPs within 2kb
    373 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97555
 protein coding gene ChrX:105230706-105247305 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036004
 protein coding gene ChrX:102978006-102994590 (+)
A/J MGP_AJ_G0035983
 protein coding gene ChrX:102750285-102769444 (+)
AKR/J MGP_AKRJ_G0035902
 protein coding gene ChrX:106037214-106055371 (+)
BALB/cJ MGP_BALBcJ_G0035973
 protein coding gene ChrX:101584059-101603644 (+)
C3H/HeJ MGP_C3HHeJ_G0035680
 protein coding gene ChrX:103407433-103424483 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036500
 protein coding gene ChrX:105914158-105933142 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033328
 protein coding gene ChrX:100209354-100225468 (+)
CAST/EiJ MGP_CASTEiJ_G0034967
 protein coding gene ChrX:87556070-87574028 (+)
CBA/J MGP_CBAJ_G0035655
 protein coding gene ChrX:109235132-109251244 (+)
DBA/2J MGP_DBA2J_G0035809
 protein coding gene ChrX:102031089-102048050 (+)
FVB/NJ MGP_FVBNJ_G0035750
 protein coding gene ChrX:101349469-101365703 (+)
LP/J MGP_LPJ_G0035902
 protein coding gene ChrX:103942862-103960840 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035782
 protein coding gene ChrX:113927359-113948201 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036526
 protein coding gene ChrX:102609881-102626492 (+)
PWK/PhJ MGP_PWKPhJ_G0034663
 protein coding gene ChrX:85084363-85102415 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034492
 protein coding gene ChrX:88291689-88308292 (+)
WSB/EiJ MGP_WSBEiJ_G0035105
 protein coding gene ChrX:101314601-101333823 (+)



Homology
more
  • Human Ortholog
    PGK1, phosphoglycerate kinase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGK1, phosphoglycerate kinase 1
  • Synonyms
    HEL-S-68p, MIG10, PGKA
  • Links
    NCBI Gene ID: 5230
    neXtProt AC: NX_P00558
    UniProt: P00558

  • Chr Location
    Xq21.1; chrX:77910739-78129295 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PGK1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1093
  • Tissues
    220
  • cDNA Data
    21
  • Literature Summary
    61
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 18655 NCBI Gene Model | MGI Sequence Detail 16600 C57BL/6J ±  kb
transcript NM_008828 RefSeq | MGI Sequence Detail 1840 ZRU/MplStud  
polypeptide P09411 UniProt | EBI | MGI Sequence Detail 417 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    Genomic 19
    cDNA 26
    Primer pair 9
    Other 6

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-13258, MGD-MRK-13266
References
more
  • Summaries
    All 184
    Developmental Gene Expression 61
    Gene Ontology 17
    Phenotypes 6
  • Earliest
    J:320603 Crisp DM, et al., Glycolytic and gluconeogenic enzyme activities in parenchymal and non-parenchymal cells from mouse liver. Biochem J. 1972 Feb;126(4):1009-23
  • Latest
    J:346347 Xu T, et al., Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling. Redox Biol. 2023 Mar 20;62:102682
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory