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Mboat4 Gene Detail
Summary
  • Symbol
    Mboat4
  • Name
    membrane bound O-acyltransferase domain containing 4
  • Synonyms
    GOAT, LOC234155
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685017
    NCBI Gene: 234155
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:34582184-34592336 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 20.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    522 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685017
 protein coding gene Chr8:34575032-34592336 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033531
 protein coding gene Chr8:32615398-32626547 (+)
A/J MGP_AJ_G0033511
 protein coding gene Chr8:31333857-31343939 (+)
AKR/J MGP_AKRJ_G0033435
 protein coding gene Chr8:32323094-32333156 (+)
BALB/cJ MGP_BALBcJ_G0033507
 protein coding gene Chr8:31454297-31464385 (+)
C3H/HeJ MGP_C3HHeJ_G0033219
 protein coding gene Chr8:32637096-32649335 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034023
 protein coding gene Chr8:33832612-33842747 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030972
 protein coding gene Chr8:28329604-28339087 (+)
CAST/EiJ MGP_CASTEiJ_G0032546
 protein coding gene Chr8:32102966-32114731 (+)
CBA/J MGP_CBAJ_G0033197
 protein coding gene Chr8:35154867-35164945 (+)
DBA/2J MGP_DBA2J_G0033350
 protein coding gene Chr8:31310352-31322562 (+)
FVB/NJ MGP_FVBNJ_G0033295
 protein coding gene Chr8:30966904-30976995 (+)
LP/J MGP_LPJ_G0033440
 protein coding gene Chr8:32568851-32578939 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033337
 protein coding gene Chr8:34683933-34697675 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034042
 protein coding gene Chr8:32394748-32406481 (+)
PWK/PhJ MGP_PWKPhJ_G0032258
 protein coding gene Chr8:30837998-30848280 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032089
 protein coding gene Chr8:31662722-31673761 (+)
WSB/EiJ MGP_WSBEiJ_G0032662
 protein coding gene Chr8:32566299-32576417 (+)



Homology
more
  • Human Ortholog
    MBOAT4, membrane bound O-acyltransferase domain containing 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MBOAT4, membrane bound O-acyltransferase domain containing 4
  • Synonyms
    FKSG89, GOAT, OACT4
  • Links
    NCBI Gene ID: 619373
    neXtProt AC: NX_Q96T53
    UniProt: Q96T53

  • Chr Location
    8p12; chr8:30131671-30144665 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 4 alleles in 4 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations lack the mature form of ghrelin in the plasma and display abnormal responses to changes in diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    3
  • cDNA Data
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071113 Ensembl Gene Model | MGI Sequence Detail 10153 C57BL/6J ±  kb
    transcript ENSMUST00000095345 Ensembl | MGI Sequence Detail 1836 Not Applicable  
    polypeptide ENSMUSP00000092988 Ensembl | MGI Sequence Detail 435 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 1
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 25
    • Earliest
      J:134640 Gutierrez JA, et al., Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6320-5
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory