Calm2 MGI Mouse Gene Detail - MGI:103250

Symbol

Calm2
Name

calmodulin 2
Synonyms

1500001E21Rik

Feature Type

protein coding gene
IDs

MGI:103250
NCBI Gene: 12314
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:87740840-87754363 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 57.49 cM
Mapping Data

2 experiments

SNPs within 2kb

317 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103250	protein coding gene	Chr17:87740829-87754363 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024103	protein coding gene	Chr17:90826406-90840562 (-)
A/J	MGP_AJ_G0024062	protein coding gene	Chr17:87900144-87921622 (-)
AKR/J	MGP_AKRJ_G0024031	protein coding gene	Chr17:89375956-89388847 (-)
BALB/cJ	MGP_BALBcJ_G0024063	protein coding gene	Chr17:87751005-87764075 (-)
C3H/HeJ	MGP_C3HHeJ_G0023828	protein coding gene	Chr17:90252005-90265344 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024508	protein coding gene	Chr17:93952518-93970261 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021947	protein coding gene	Chr17:83038733-83051143 (-)
CAST/EiJ	MGP_CASTEiJ_G0023307	protein coding gene	Chr17:91082142-91098114 (-)
CBA/J	MGP_CBAJ_G0023802	protein coding gene	Chr17:97904033-97918996 (-)
DBA/2J	MGP_DBA2J_G0023930	protein coding gene	Chr17:86330113-86343835 (-)
FVB/NJ	MGP_FVBNJ_G0023896	protein coding gene	Chr17:85847079-85861071 (-)
LP/J	MGP_LPJ_G0024014	protein coding gene	Chr17:91618687-91631443 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023924	protein coding gene	Chr17:97772512-97793565 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024553	protein coding gene	Chr17:89894993-89910004 (-)
PWK/PhJ	MGP_PWKPhJ_G0023052	protein coding gene	Chr17:85972943-85993840 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022863	protein coding gene	Chr17:86635160-86652318 (-)
WSB/EiJ	MGP_WSBEiJ_G0023373	protein coding gene	Chr17:90740462-90753310 (-)

Human Ortholog

CALM2, calmodulin 2

Vertebrate Orthologs

10

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CALM2, calmodulin 2
Synonyms

CALM, CALML2, caM, CAM1, CAM3, CAMC, CAMII, CAMIII, LQT15, PHKD, PHKD2
Links

HGNC:1445

NCBI Gene ID: 805

neXtProt AC: NX_P0DP23, NX_P0DP24, NX_P0DP25

UniProt: P0DP24
Chr Location

2p21; chr2:47160082-47176936 (-) GRCh38

MGI Vertebrate Homology

Calm2 stringent orthology
1 human;1 mouse;3 rat;6 zebrafish
HCOP

vertebrate homology predictions: CALM2
Gene Tree

Calm2

Diseases

1 with human CALM2 associations

				Human Disease	Mouse Models
				long QT syndrome 15 IDs long QT syndrome 15 DOID:0110656 ICD10CM:I45.8 OMIM:616249

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

3
Gene trapped

13
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

150
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

863
Tissues

144
cDNA Data

732
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CALML3

Xenbase calm2

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All Sequences

58
RefSeq

4
UniProt

1
CCDS

CCDS37716.1, CCDS89167.1

Ensembl

ENSMUSG00000036438 (Evidence)
NCBI Gene

12314

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036438	Ensembl Gene Model \| MGI Sequence Detail	13524	C57BL/6J	± kb
transcript	ENSMUST00000040440	Ensembl \| MGI Sequence Detail	1205	Not Applicable
polypeptide	ENSMUSP00000048857	Ensembl \| MGI Sequence Detail	149	Not Applicable

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UniProt

1 Sequence

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All nucleic 737

cDNA 734

Primer pair 1

Other 2

Microarray probesets 5

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MGD-MRK-24126, MGI:1922950, MGI:2146954

Summaries

All 59

Developmental Gene Expression 11

Gene Ontology 14

Phenotypes 9
Earliest

J:19936 Bender PK, et al., The abundance of calmodulin mRNAs is regulated in phosphorylase kinase-deficient skeletal muscle. J Biol Chem. 1988 Jul 15;263(20):9733-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Calm2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr149773	Chr17:87754282-87754297 (-)	73 bp
Tssr149772	Chr17:87748343-87748348 (-)	6,017 bp
Tssr149771	Chr17:87746101-87746118 (-)	8,253 bp
Tssr149770	Chr17:87745947-87745964 (-)	8,407 bp
Tssr149769	Chr17:87741367-87741378 (-)	12,990 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24