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Cd8b1 Gene Detail
Summary
  • Symbol
    Cd8b1
  • Name
    CD8 subunit beta 1
  • Synonyms
    Ly-3, Ly-C, Lyt-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:88347
    NCBI Gene: 12526
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:71299772-71314476 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 32.14 cM
  • Mapping Data
    39 experiments
Strain
Comparison
more
  • SNPs within 2kb
    419 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    6
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88347
 protein coding gene Chr6:71299772-71314478 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030856
 protein coding gene Chr6:71792258-71809204 (+)
A/J MGP_AJ_G0030826
 protein coding gene Chr6:69031964-69048274 (+)
AKR/J MGP_AKRJ_G0030755
 protein coding gene Chr6:71014415-71030684 (+)
BALB/cJ MGP_BALBcJ_G0030837
 protein coding gene Chr6:69065879-69080953 (+)
C3H/HeJ MGP_C3HHeJ_G0030875
 protein coding gene Chr6:113217413-113233081 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031295
 protein coding gene Chr6:73686459-73703065 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028484
 protein coding gene Chr6:68215700-68230255 (+)
CAST/EiJ MGP_CASTEiJ_G0029945
 protein coding gene Chr6:70875116-70890976 (+)
CBA/J MGP_CBAJ_G0030524
 protein coding gene Chr6:76609243-76623949 (+)
DBA/2J MGP_DBA2J_G0030676
 protein coding gene Chr6:68405167-68419863 (+)
FVB/NJ MGP_FVBNJ_G0030629
 protein coding gene Chr6:67776472-67791169 (+)
LP/J MGP_LPJ_G0030755
 protein coding gene Chr6:71721342-71736046 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030664
 protein coding gene Chr6:80104418-80119046 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031321
 protein coding gene Chr6:70859562-70877102 (+)
PWK/PhJ MGP_PWKPhJ_G0029661
 protein coding gene Chr6:67281006-67292634 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029489
 protein coding gene Chr6:69568304-69582629 (+)
WSB/EiJ MGP_WSBEiJ_G0030027
 protein coding gene Chr6:71200665-71215344 (+)



Homology
more
  • Human Ortholog
    CD8B, CD8 subunit beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD8B, CD8 subunit beta
  • Synonyms
    CD8B1, CD8beta, LEU2, Ly-3, LY3, LYT3, P37
  • Links
    NCBI Gene ID: 926
    neXtProt AC: NX_P10966
    UniProt: P10966

  • Chr Location
    2p11.2; chr2:86815339-86861924 (-)  GRCh38
  • Human Ortholog
    CD8B2, CD8B family member 2
  • Synonyms
    CD8BP
  • Links
    NCBI Gene ID: 927
    UniProt: A6NJW9

  • Chr Location
    2q12.2; chr2:106487364-106544297 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 5 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for a mutation in this gene lack CD8+CD4- cytotoxic T cells in the thymus and spleen and do not mount a cytotoxic response to alloantigens.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    46
  • cDNA Data
    17
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12526 NCBI Gene Model | MGI Sequence Detail 14705 C57BL/6J ±  kb
    transcript NM_009858 RefSeq | MGI Sequence Detail 1481 ZRU/MplStud  
    polypeptide P10300 UniProt | EBI | MGI Sequence Detail 213 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 8
      cDNA 18
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11970, MGD-MRK-12075, MGD-MRK-1873
    References
    more
    • Summaries
      All 136
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:5214 Boyse EA, et al., Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes. Transplantation. 1971 Mar;11(3):351-3
    • Latest
      J:331514 Shinzawa M, et al., Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus. Nat Immunol. 2022 May;23(5):731-742
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory