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Plat Gene Detail
Summary
  • Symbol
    Plat
  • Name
    plasminogen activator, tissue
  • Synonyms
    D8Ertd2e, MGC:18508, t-PA, tPA
  • Feature Type
    protein coding gene
  • IDs
    MGI:97610
    NCBI Gene: 18791
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:23247743-23272860 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.42 cM
  • Mapping Data
    38 experiments
Strain
Comparison
more
  • SNPs within 2kb
    907 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97610
 protein coding gene Chr8:23247655-23272864 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033458
 protein coding gene Chr8:20616686-20647668 (+)
A/J MGP_AJ_G0033438
 protein coding gene Chr8:19945606-19975350 (+)
AKR/J MGP_AKRJ_G0033363
 protein coding gene Chr8:20602630-20631820 (+)
BALB/cJ MGP_BALBcJ_G0033434
 protein coding gene Chr8:20069094-20098429 (+)
C3H/HeJ MGP_C3HHeJ_G0033148
 protein coding gene Chr8:20799429-20831852 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033950
 protein coding gene Chr8:21482094-21511448 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0032474
 protein coding gene Chr8:20213744-20243208 (+)
CBA/J MGP_CBAJ_G0033123
 protein coding gene Chr8:22341516-22373783 (+)
DBA/2J MGP_DBA2J_G0033278
 protein coding gene Chr8:19914639-19944429 (+)
FVB/NJ MGP_FVBNJ_G0033222
 protein coding gene Chr8:19709800-19739556 (+)
LP/J MGP_LPJ_G0033367
 protein coding gene Chr8:20609123-20638464 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033265
 protein coding gene Chr8:21934931-21964913 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033969
 protein coding gene Chr8:20505744-20535095 (+)
PWK/PhJ MGP_PWKPhJ_G0032186
 protein coding gene Chr8:19503175-19532869 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032019
 protein coding gene Chr8:19894127-19910586 (+)
WSB/EiJ MGP_WSBEiJ_G0032590
 protein coding gene Chr8:20708789-20737942 (+)



Homology
more
  • Human Ortholog
    PLAT, plasminogen activator, tissue type
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLAT, plasminogen activator, tissue type
  • Synonyms
    T-PA, TPA
  • Links
    NCBI Gene ID: 5327
    neXtProt AC: NX_P00750
    UniProt: P00750

  • Chr Location
    8p11.21; chr8:42174718-42207709 (-)  GRCh38
Human Diseases
more
  • Diseases
    8 with human PLAT associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 2 alleles in 6 genetic backgrounds
    16 phenotypes from multigenic genotypes
    165 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal behavior, CNS synpatic transmission, and response to injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    981
  • Tissues
    167
  • cDNA Data
    101
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031538 Ensembl Gene Model | MGI Sequence Detail 25118 C57BL/6J ±  kb
    transcript ENSMUST00000033941 Ensembl | MGI Sequence Detail 2525 Not Applicable  
    polypeptide ENSMUSP00000033941 Ensembl | MGI Sequence Detail 559 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 115
      Genomic 2
      cDNA 102
      Primer pair 6
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13346, MGI:1098659, MGI:2142697, MGI:2142776
    References
    more
    • Summaries
      All 308
      Developmental Gene Expression 33
      Gene Ontology 11
      Phenotypes 165
    • Earliest
      J:8866 Rajput B, et al., Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse. Somat Cell Mol Genet. 1987 Sep;13(5):581-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory