Mpo MGI Mouse Gene Detail - MGI:97137

Symbol

Mpo
Name

myeloperoxidase

Feature Type

protein coding gene
IDs

MGI:97137
NCBI Gene: 17523
Alliance

gene page
Transcription Start Sites

36 TSS

Sequence Map

Chr11:87684610-87695238 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 52.22 cM, cytoband C
Mapping Data

34 experiments

SNPs within 2kb

164 from dbSNP Build 142
Strain Annotations

18
PCR

3
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97137	protein coding gene	Chr11:87684407-87695239 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018912	protein coding gene	Chr11:89426197-89438078 (+)
A/J	MGP_AJ_G0018879	protein coding gene	Chr11:85979739-85991108 (+)
AKR/J	MGP_AKRJ_G0018849	protein coding gene	Chr11:88553855-88564936 (+)
BALB/cJ	MGP_BALBcJ_G0018852	protein coding gene	Chr11:86380895-86392014 (+)
C3H/HeJ	MGP_C3HHeJ_G0018666	protein coding gene	Chr11:88594371-88608018 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019304	protein coding gene	Chr11:92142850-92153785 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016937	protein coding gene	Chr11:83007979-83018799 (+)
CAST/EiJ	MGP_CASTEiJ_G0018221	protein coding gene	Chr11:89289184-89304030 (+)
CBA/J	MGP_CBAJ_G0018637	protein coding gene	Chr11:96011144-96029986 (+)
DBA/2J	MGP_DBA2J_G0018745	protein coding gene	Chr11:85533646-85544391 (+)
FVB/NJ	MGP_FVBNJ_G0018734	protein coding gene	Chr11:85039488-85050532 (+)
LP/J	MGP_LPJ_G0018815	protein coding gene	Chr11:89918540-89930596 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018761	protein coding gene	Chr11:96050590-96061951 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019344	protein coding gene	Chr11:88791386-88803539 (+)
PWK/PhJ	MGP_PWKPhJ_G0017991	protein coding gene	Chr11:86382787-86394240 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017784	protein coding gene	Chr11:88350529-88362822 (+)
WSB/EiJ	MGP_WSBEiJ_G0018272	protein coding gene	Chr11:88684108-88695588 (+)

Human Ortholog

MPO, myeloperoxidase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MPO, myeloperoxidase
Links

HGNC:7218

NCBI Gene ID: 4353

neXtProt AC: NX_P05164

UniProt: P05164
Chr Location

17q22; chr17:58269855-58280935 (-) GRCh38

MGI Vertebrate Homology

Mpo stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MPO
Gene Tree

Mpo

Diseases

14 with human MPO associations

				Human Disease	Mouse Models
				acute kidney failure IDs acute kidney failure DOID:3021 MESH:D058186
				Alzheimer's disease 1 IDs Alzheimer's disease 1 DOID:0080348 OMIM:104300
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				cardiovascular system disease IDs cardiovascular system disease DOID:1287 DOID:73 ICD9CM:429.2 MESH:D002318 NCI:C2931 UMLS_CUI:C0007222
				cystic fibrosis IDs cystic fibrosis DOID:1485 DOID:12447 DOID:13383 DOID:14395 DOID:1484 ICD10CM:E84 ICD9CM:277.0 MESH:D003550 NCI:C2975 OMIM:219700 ORDO:586 UMLS_CUI:C0010674
				end stage renal disease IDs end stage renal disease DOID:783
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				keratosis IDs keratosis DOID:161 MESH:D007642 NCI:C34747 UMLS_CUI:C0022593
				liver cirrhosis IDs liver cirrhosis DOID:5082 EFO:0001422 ICD10CM:K74.60 MESH:D008103 NCI:C2951 UMLS_CUI:C0023890
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493
				lung disease IDs lung disease DOID:850 DOID:11894 DOID:11895 DOID:29 DOID:766 ICD10CM:J98.4 MESH:D008171 NCI:C3198 UMLS_CUI:C0024115
				lupus nephritis IDs lupus nephritis DOID:0080162 MESH:D008181
				pancreatic cancer IDs pancreatic cancer DOID:1793 DOID:14356 DOID:1797 DOID:3588 DOID:9859 ICD10CM:C25.0 ICD10CM:C25.1 ICD10CM:C25.2 ICD9CM:157.0 ICD9CM:157.1 ICD9CM:157.2 ICD9CM:157.8 KEGG:05212 MESH:D010190 NCI:C3305 ORDO:1333 ORDO:217074 UMLS_CUI:C0030297 UMLS_CUI:C0153458 UMLS_CUI:C0153459 UMLS_CUI:C0153460 UMLS_CUI:C0153463
				vasculitis IDs vasculitis DOID:865 MESH:D014657 NCI:C26912 UMLS_CUI:C0042384

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

12 phenotypes from 2 alleles in 4 genetic backgrounds
89 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

9
Genomic Mutations

4 involving Mpo
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

55 strains or lines available

Homozygous inactivation of this gene causes neutrophil dysfunction and decreased resistance to fungal infection with Candida, and may lead to enhanced atherosclerosis, reduced neutrophil-mediated lysis of muscle cells, decreased resistance to EAE, and altered asbestos-induced lung inflammation.

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All GO Annotations

37
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

964
Tissues

112
cDNA Data

253
Literature Summary

16

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mpo

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All Sequences

50
RefSeq

2
UniProt

7
CCDS

CCDS25217.1

Ensembl

ENSMUSG00000009350 (Evidence)
NCBI Gene

17523

			Length	Strain/Species	Flank
genomic	17523	NCBI Gene Model \| MGI Sequence Detail	10629	C57BL/6J	± kb
transcript	NM_010824	RefSeq \| MGI Sequence Detail	2570	C57BL/6NCrl
polypeptide	P11247	UniProt \| EBI \| MGI Sequence Detail	718	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000010543 myeloperoxidase

(term hierarchy)
EC

1.11.2.2
InterPro Domains

IPR019791 Haem peroxidase, animal-type

IPR037120 Haem peroxidase domain superfamily, animal type

IPR010255 Haem peroxidase superfamily

IPR050702 Peroxidase Activity and Reactive Species Generation
GlyGen

P11247 6 sites, 6 N-linked glycans (4 sites)

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All nucleic 266

Genomic 4

cDNA 253

Primer pair 5

Other 4

Microarray probesets 4

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MGD-MRK-12530

Summaries

All 193

Developmental Gene Expression 16

Diseases 1

Gene Ontology 13

Phenotypes 89
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:352001 Zheng R, et al., Remodeling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO. iScience. 2024 Feb 16;27(2):108898

TSS for Mpo:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103978	Chr11:87684232-87684241 (+)	-373 bp
Tssr103979	Chr11:87684258-87684271 (+)	-345 bp
Tssr103980	Chr11:87684296-87684309 (+)	-307 bp
Tssr103981	Chr11:87684548-87684631 (+)	-20 bp
Tssr103982	Chr11:87684635-87684654 (+)	35 bp
Tssr103983	Chr11:87684657-87684673 (+)	55 bp
Tssr103984	Chr11:87684845-87684858 (+)	242 bp
Tssr103985	Chr11:87684869-87684883 (+)	266 bp
Tssr103986	Chr11:87684885-87684897 (+)	281 bp
Tssr103987	Chr11:87685032-87685038 (+)	425 bp
Tssr103988	Chr11:87685347-87685362 (+)	745 bp
Tssr3631	Chr11:87685576-87685594 (+)	975 bp
Tssr103989	Chr11:87685605-87685641 (+)	1,013 bp
Tssr103990	Chr11:87686039-87686053 (+)	1,436 bp
Tssr3632	Chr11:87686088-87686094 (+)	1,481 bp
Tssr103991	Chr11:87686112-87686126 (+)	1,509 bp
Tssr103992	Chr11:87686133-87686144 (+)	1,529 bp
Tssr103993	Chr11:87686609-87686618 (+)	2,004 bp
Tssr103994	Chr11:87686681-87686700 (+)	2,081 bp
Tssr103995	Chr11:87686857-87686869 (+)	2,253 bp
Tssr103996	Chr11:87686909-87686919 (+)	2,304 bp
Tssr103997	Chr11:87687079-87687089 (+)	2,474 bp
Tssr3633	Chr11:87687139-87687165 (+)	2,542 bp
Tssr103998	Chr11:87687186-87687234 (+)	2,600 bp
Tssr103999	Chr11:87688142-87688157 (+)	3,540 bp
Tssr104000	Chr11:87688254-87688271 (+)	3,653 bp
Tssr104001	Chr11:87688284-87688297 (+)	3,681 bp
Tssr104002	Chr11:87688310-87688319 (+)	3,705 bp
Tssr104003	Chr11:87688383-87688394 (+)	3,779 bp
Tssr104004	Chr11:87688409-87688416 (+)	3,803 bp
Tssr104005	Chr11:87688433-87688443 (+)	3,828 bp
Tssr104006	Chr11:87690715-87690726 (+)	6,111 bp
Tssr104007	Chr11:87690798-87690810 (+)	6,194 bp
Tssr3635	Chr11:87691843-87691849 (+)	7,236 bp
Tssr104008	Chr11:87691867-87691877 (+)	7,262 bp
Tssr104009	Chr11:87692042-87692088 (+)	7,455 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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