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Lamp1 Gene Detail
Summary
  • Symbol
    Lamp1
  • Name
    lysosomal-associated membrane protein 1
  • Synonyms
    CD107a, Lamp-1, Perk
  • Feature Type
    protein coding gene
  • IDs
    MGI:96745
    NCBI Gene: 16783
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:13209161-13225338 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 5.73 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    378 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96745
 protein coding gene Chr8:13209161-13225338 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033373
 protein coding gene Chr8:10484849-10501811 (+)
A/J MGP_AJ_G0033353
 protein coding gene Chr8:10111998-10128285 (+)
AKR/J MGP_AKRJ_G0033284
 protein coding gene Chr8:10377406-10393525 (+)
BALB/cJ MGP_BALBcJ_G0033354
 protein coding gene Chr8:10244521-10261255 (+)
C3H/HeJ MGP_C3HHeJ_G0033067
 protein coding gene Chr8:10592514-10610078 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033866
 protein coding gene Chr8:10850178-10869696 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030835
 protein coding gene Chr8:9614329-9631598 (+)
CAST/EiJ MGP_CASTEiJ_G0032389
 protein coding gene Chr8:10344274-10360493 (+)
CBA/J MGP_CBAJ_G0033040
 protein coding gene Chr8:11303127-11322004 (+)
DBA/2J MGP_DBA2J_G0033193
 protein coding gene Chr8:10062106-10078279 (+)
FVB/NJ MGP_FVBNJ_G0033142
 protein coding gene Chr8:10073590-10090006 (+)
LP/J MGP_LPJ_G0033287
 protein coding gene Chr8:10399456-10415764 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033176
 protein coding gene Chr8:11548441-11565799 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033883
 protein coding gene Chr8:10440870-10457591 (+)
PWK/PhJ MGP_PWKPhJ_G0032102
 protein coding gene Chr8:10109879-10126263 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031944
 protein coding gene Chr8:10334317-10350309 (+)
WSB/EiJ MGP_WSBEiJ_G0032505
 protein coding gene Chr8:10473123-10489305 (+)



Homology
more
  • Human Ortholog
    LAMP1, lysosomal associated membrane protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAMP1, lysosomal associated membrane protein 1
  • Synonyms
    CD107a, LAMPA, LGP120
  • Links
    NCBI Gene ID: 3916
    neXtProt AC: NX_P11279
    UniProt: P11279

  • Chr Location
    13q34; chr13:113297239-113323672 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    52
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    43
  • cDNA Data
    476
  • Literature Summary
    73
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16783 NCBI Gene Model | MGI Sequence Detail 16178 C57BL/6J ±  kb
    transcript NM_001317353 RefSeq | MGI Sequence Detail 2242 ZRU/MplStud  
    polypeptide P11438 UniProt | EBI | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000002060 lysosome-associated membrane glycoprotein 1
      (term hierarchy)
    • PDB
      5GV0
    • InterPro Domains
      IPR002000 Lysosome-associated membrane glycoprotein
      IPR048528 Lysosome-associated membrane glycoprotein 2-like, luminal domains
      IPR048524 Lysosome-associated membrane glycoprotein 2-like, transmembrane domain
      IPR018134 Lysosome-associated membrane glycoprotein, conserved site
    • GlyGen
      P11438 20 sites, 38 N-linked glycans (16 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 480
      cDNA 476
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11740, MGD-MRK-11742, MGI:2142479
    References
    more
    • Summaries
      All 212
      Developmental Gene Expression 73
      Gene Ontology 52
      Phenotypes 15
    • Earliest
      J:8849 Green SA, et al., Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins. J Cell Biol. 1987 Sep;105(3):1227-40
    • Latest
      J:346909 Ha HT, et al., Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models. JCI Insight. 2024 Mar 7;:e175462
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory