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Hsp90ab1 Gene Detail
Summary
  • Symbol
    Hsp90ab1
  • Name
    heat shock protein 90 alpha (cytosolic), class B member 1
  • Synonyms
    C81438, Hsp84, Hsp84-1, Hsp90, Hspcb
  • Feature Type
    protein coding gene
  • IDs
    MGI:96247
    NCBI Gene: 15516
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:45878704-45884187 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.59 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96247
 protein coding gene Chr17:45878701-45884197 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023793
 protein coding gene Chr17:46586861-46592357 (-)
A/J MGP_AJ_G0023751
 protein coding gene Chr17:45469519-45475025 (-)
AKR/J MGP_AKRJ_G0023722
 protein coding gene Chr17:45784400-45789909 (-)
BALB/cJ MGP_BALBcJ_G0023755
 protein coding gene Chr17:45359322-45364831 (-)
C3H/HeJ MGP_C3HHeJ_G0023519
 protein coding gene Chr17:46495211-46500720 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024198
 protein coding gene Chr17:48598768-48604264 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021648
 protein coding gene Chr17:42266662-42272148 (-)
CAST/EiJ MGP_CASTEiJ_G0023000
 protein coding gene Chr17:46594089-46599601 (-)
CBA/J MGP_CBAJ_G0023495
 protein coding gene Chr17:50323130-50328639 (-)
DBA/2J MGP_DBA2J_G0023621
 protein coding gene Chr17:44260548-44266054 (-)
FVB/NJ MGP_FVBNJ_G0023588
 protein coding gene Chr17:43837090-43842596 (-)
LP/J MGP_LPJ_G0023702
 protein coding gene Chr17:47232948-47238444 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023617
 protein coding gene Chr17:49890451-49895957 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024243
 protein coding gene Chr17:46148457-46153963 (-)
PWK/PhJ MGP_PWKPhJ_G0022745
 protein coding gene Chr17:43568288-43573815 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022560
 protein coding gene Chr17:43012056-43017606 (-)
WSB/EiJ MGP_WSBEiJ_G0023065
 protein coding gene Chr17:46667132-46672638 (-)



Homology
more
  • Human Ortholog
    HSP90AB1, heat shock protein 90 alpha family class B member 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSP90AB1, heat shock protein 90 alpha family class B member 1
  • Synonyms
    D6S182, HSP84, HSP90B, HSPC2, HSPCB
  • Links
    NCBI Gene ID: 3326
    neXtProt AC: NX_P08238
    UniProt: P08238

  • Chr Location
    6p21.1; chr6:44246166-44253888 (+)  GRCh38
  • Human Ortholog
    HSP90AB2P, heat shock protein 90 alpha family class B member 2, pseudogene
  • Synonyms
    HSP90BB
  • Links
    NCBI Gene ID: 391634
    UniProt: Q58FF8

  • Chr Location
    4p15.33; chr4:13336387-13338931 (+)  GRCh38
  • Human Ortholog
    HSP90AB3P, heat shock protein 90 alpha family class B member 3, pseudogene
  • Synonyms
    HSP90BC, HSPCP1
  • Links
    NCBI Gene ID: 3327
    UniProt: Q58FF7

  • Chr Location
    4q22.1; chr4:87891748-87894288 (+)  GRCh38
  • Human Ortholog
    HSP90AB4P, heat shock protein 90 alpha family class B member 4, pseudogene
  • Synonyms
    HSP90Bd
  • Links
    NCBI Gene ID: 664618
    UniProt: Q58FF6

  • Chr Location
    15q21.3; chr15:58690473-58693607 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HSP90AB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a gene-trapped null mutation exhibit placental defects including failure to form a placental labyrinth and lack of expansion of allantoic blood vessels. Mutants die around mid-gestation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    125
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    919
  • Tissues
    155
  • cDNA Data
    2022
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15516 NCBI Gene Model | MGI Sequence Detail 5484 C57BL/6J ±  kb
    transcript NM_008302 RefSeq | MGI Sequence Detail 2507 ZRU/MplStud  
    polypeptide P11499 UniProt | EBI | MGI Sequence Detail 724 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000008800 heat shock protein HSP 90-beta
      (term hierarchy)
    • PDB
      7Y04, 8H77
    • InterPro Domains
      IPR019805 Heat shock protein Hsp90, conserved site
      IPR001404 Heat shock protein Hsp90 family
      IPR020575 Heat shock protein Hsp90, N-terminal
      IPR003594 Histidine kinase/HSP90-like ATPase
      IPR036890 Histidine kinase/HSP90-like ATPase superfamily
      IPR037196 HSP90, C-terminal domain
      IPR020568 Ribosomal protein uS5 domain 2-type superfamily
    • GlyGen
      P11499 7 sites, 2 N-linked glycans (3 sites), 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 2028
      cDNA 2026
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10963, MGD-MRK-10974, MGI:2146951, MGI:2147140
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 19
      Gene Ontology 25
      Phenotypes 13
    • Earliest
      J:30948 Ullrich SJ, et al., A mouse tumor-specific transplantation antigen is a heat shock-related protein. Proc Natl Acad Sci U S A. 1986 May;83(10):3121-5
    • Latest
      J:349721 Borisova E, et al., Protein translation rate determines neocortical neuron fate. Nat Commun. 2024 Jun 7;15(1):4879
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory