Itgb2 Gene Detail

Summary

• Symbol
  Itgb2
• Name
  integrin beta 2
• Synonyms
  2E6, Cd18, Mac-1 beta

• Feature Type
  protein coding gene
• IDs
  MGI:96611
  NCBI Gene: 16414
• Alliance
  gene page
• Transcription Start Sites
  35 TSS
• Candidate for QTL
  3 QTL

Location &
Maps

• Sequence Map
  Chr10:77366164-77401542 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, 39.72 cM
• Mapping Data
  15 experiments

Strain
Comparison

• SNPs within 2kb
  874 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  2

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96611	protein coding gene	Chr10:77366086-77401542 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017398	protein coding gene	Chr10:77850882-77900452 (+)
A/J	MGP_AJ_G0017375	protein coding gene	Chr10:75150531-75185900 (+)
AKR/J	MGP_AKRJ_G0017336	protein coding gene	Chr10:77156402-77193438 (+)
BALB/cJ	MGP_BALBcJ_G0017335	protein coding gene	Chr10:75345523-75381087 (+)
C3H/HeJ	MGP_C3HHeJ_G0017159	protein coding gene	Chr10:77241326-77277394 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017793	protein coding gene	Chr10:80581140-80616577 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015483	protein coding gene	Chr10:71580863-71617746 (+)
CAST/EiJ	MGP_CASTEiJ_G0016729	protein coding gene	Chr10:77591770-77634710 (+)
CBA/J	MGP_CBAJ_G0017131	protein coding gene	Chr10:83703545-83740707 (+)
DBA/2J	MGP_DBA2J_G0017236	protein coding gene	Chr10:74429455-74464808 (+)
FVB/NJ	MGP_FVBNJ_G0017228	protein coding gene	Chr10:73602466-73639583 (+)
LP/J	MGP_LPJ_G0017309	protein coding gene	Chr10:78326703-78363655 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017257	protein coding gene	Chr10:85735818-85774198 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017832	protein coding gene	Chr10:77235749-77273103 (+)
PWK/PhJ	MGP_PWKPhJ_G0016513	protein coding gene	Chr10:74308380-74344595 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016296	protein coding gene	Chr10:76497447-76532502 (+)
WSB/EiJ	MGP_WSBEiJ_G0016792	protein coding gene	Chr10:77209714-77246355 (+)

Homology

• Human Ortholog
  ITGB2, integrin subunit beta 2

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  ITGB2, integrin subunit beta 2
  
• Synonyms
  CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
• Links
  HGNC:6155

  NCBI Gene ID: 3689

  neXtProt AC: NX_P05107

  UniProt: P05107

  
  
• Chr Location
  21q22.3; chr21:44885953-44931989 (-)  GRCh38

---

• MGI Vertebrate Homology
  Itgb2 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: ITGB2
• Protein SuperFamily
  Integrin_B
• Gene Tree
  Itgb2
  

Human Diseases

• Diseases
  2 with Itgb2 mouse models; 3 with human ITGB2 associations

Human Disease

Mouse Models

leukocyte adhesion deficiency 1

IDs

leukocyte adhesion deficiency 1      

DOID:0110910
OMIM:116920
ORDO:99842

View 3 models

Mouse Models

Human Disease Modeled: leukocyte adhesion deficiency 1

Allelic Composition	Genetic Background	Reference	Phenotypes
Itgb2tm1Bay/Itgb2tm1Bay	involves: 129S7/SvEvBrd	J:13599	View
Itgb2tm1Bay/Itgb2tm1Bay	involves: 129S7/SvEvBrd * C57BL/6J	J:13599	View
Itgb2tm2Bay/Itgb2tm2Bay	involves: 129S7/SvEvBrd * C57BL/6J	J:48542	View

psoriasis

IDs

psoriasis      

DOID:8893
EFO:0000676
ICD10CM:L40
MESH:D011565
NCI:C3346
OMIM:PS177900
UMLS_CUI:C0033860

View 5 models

Mouse Models

Human Disease Modeled: psoriasis

Allelic Composition	Genetic Background	Reference	Phenotypes
Itgb2tm1Bay/Itgb2tm1Bay	involves: 129S7/SvEvBrd * C57BL/6J * PL/J	J:32126 J:84126	View
Itgb2tm1Bay/Itgb2tm1Bay	involves: 129S7/SvEvBrd * PL/J	J:32126 J:109598	View
Itgb2tm2Bay/Itgb2tm2Bay	involves: 129S7/SvEvBrd * PL/J	J:84126	View
Itgb2tm1Bay/Itgb2tm2Bay	involves: 129S7/SvEvBrd * C57BL/6J * PL/J	J:84126	View
Itgb2tm1Bay/Itgb2tm2Bay	PL.129S7-Itgb2^tm1Bay Itgb2^tm2Bay	J:84126	View

NOT Models
No similarity to the expected human disease phenotype was found.

Allelic Composition	Genetic Background	Reference	Phenotypes
Itgb2tm1Bay/Itgb2tm2Bay	B6.129S7-Itgb2^tm1Bay Itgb2^tm2Bay	J:84126	View

coronary restenosis

IDs

coronary restenosis      

DOID:4247
MESH:D023903
UMLS_CUI:C0948480

leukocyte adhesion deficiency

IDs

leukocyte adhesion deficiency      

DOID:6612
MESH:D018370
ORDO:2968
UMLS_CUI:C0242597

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  2 with disease annotations

• References
  7 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  99 phenotypes from 9 alleles in 17 genetic backgrounds
  12 phenotypes from multigenic genotypes
  6 images
  233 phenotype references
  

• All Mutations and Alleles
  23
• Chemically induced (ENU)
  5
• Chemically induced (other)
  1
• Endonuclease-mediated
  6
• Targeted
  11
• Genomic Mutations
  4 involving Itgb2
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  50 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygotes for targeted null and hypomorphic mutations are subject to granulocytosis, impaired inflammatory and immune responses, and chronic dermatitis.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  75
• GO References
  22

Expression

• Assay Results
  958
• Tissues
  190
• cDNA Data
  42
• Literature Summary
  15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA ITGB2
  Xenbase itgb2
  ZFIN itgb2

Sequences &
Gene Models

• All Sequences
  58
• RefSeq
  10
• UniProt
  6
• CCDS
  CCDS23956.1

• Ensembl
  ENSMUSG00000000290 (Evidence)
• NCBI Gene
  16414

Representative Sequences			Length	Strain/Species
genomic	16414	NCBI Gene Model | MGI Sequence Detail	35379	C57BL/6J
transcript	NM_008404	RefSeq | MGI Sequence Detail	2874	ZRU/MplStud
polypeptide	P11835	UniProt | EBI | MGI Sequence Detail	771	Not Applicable

Protein
Information

• UniProt
  6 Sequences
• Protein Ontology
  PR:000002041 integrin beta-2
  (term hierarchy)
• InterPro Domains
  IPR015439 Integrin beta-2 superfamily
  IPR033760 Integrin beta N-terminal
  IPR015812 Integrin beta subunit
  IPR014836 Integrin beta subunit, cytoplasmic domain
  IPR012896 Integrin beta subunit, tail
  IPR002369 Integrin beta subunit, VWA domain
  IPR036349 Integrin beta tail domain superfamily
  IPR032695 Integrin domain superfamily
  IPR016201 PSI domain
  IPR036465 von Willebrand factor A-like domain superfamily
• GlyGen
  P11835 7 sites, 9 N-linked glycans (5 sites), 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 64

  Genomic 13

  cDNA 44

  Primer pair 6

  Other 1

  
  

  Microarray probesets 3

Other
Accession IDs

MGD-MRK-11490, MGD-MRK-1832, MGI:2143637

References

• Summaries
  All 420

  Developmental Gene Expression 15

  Diseases 7

  Gene Ontology 22

  Phenotypes 233
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:353994 Harjunpaa H, et al., beta2-Integrins Regulate Microglial Responses and the Functional Outcome of Hemorrhagic Stroke In Vivo. J Immunol. 2024 Aug 15;213(4):519-525

TSS for Itgb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94226	Chr10:77366176-77366246 (+)	47 bp
Tssr94227	Chr10:77366255-77366266 (+)	97 bp
Tssr94228	Chr10:77366393-77366405 (+)	235 bp
Tssr94229	Chr10:77366441-77366451 (+)	282 bp
Tssr94230	Chr10:77366462-77366476 (+)	305 bp
Tssr94231	Chr10:77371787-77371792 (+)	5,626 bp
Tssr3261	Chr10:77372900-77372935 (+)	6,754 bp
Tssr94232	Chr10:77377773-77377800 (+)	11,623 bp
Tssr94233	Chr10:77380982-77381063 (+)	14,859 bp
Tssr94234	Chr10:77381860-77381869 (+)	15,701 bp
Tssr94235	Chr10:77381942-77381953 (+)	15,784 bp
Tssr94236	Chr10:77381973-77381991 (+)	15,818 bp
Tssr94237	Chr10:77382985-77383021 (+)	16,839 bp
Tssr94238	Chr10:77383073-77383092 (+)	16,919 bp
Tssr94239	Chr10:77383655-77383663 (+)	17,495 bp
Tssr94240	Chr10:77384380-77384401 (+)	18,227 bp
Tssr94241	Chr10:77384458-77384470 (+)	18,300 bp
Tssr94242	Chr10:77385467-77385484 (+)	19,312 bp
Tssr94243	Chr10:77386322-77386341 (+)	20,168 bp
Tssr94244	Chr10:77386719-77386750 (+)	20,571 bp
Tssr94245	Chr10:77389689-77389712 (+)	23,537 bp
Tssr94246	Chr10:77389867-77389879 (+)	23,709 bp
Tssr94247	Chr10:77391212-77391248 (+)	25,066 bp
Tssr94248	Chr10:77391950-77391965 (+)	25,794 bp
Tssr94249	Chr10:77395437-77395459 (+)	29,284 bp
Tssr94250	Chr10:77396029-77396040 (+)	29,871 bp
Tssr94251	Chr10:77396064-77396076 (+)	29,906 bp
Tssr94252	Chr10:77396123-77396148 (+)	29,972 bp
Tssr94253	Chr10:77396835-77396842 (+)	30,675 bp
Tssr94254	Chr10:77396853-77396870 (+)	30,698 bp
Tssr94255	Chr10:77396902-77396925 (+)	30,750 bp
Tssr94256	Chr10:77396956-77396986 (+)	30,807 bp
Tssr94257	Chr10:77400555-77400571 (+)	34,399 bp
Tssr94258	Chr10:77400585-77400607 (+)	34,432 bp
Tssr94259	Chr10:77401222-77401244 (+)	35,069 bp

Itgb2 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bgeq8	Chr10, 66.75 cM		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.
Igfbp3q2	Chr10, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.
Insq9	Chr10, 39.72 cM	Chr10:82490938-82491121	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.

*cM position of peak correlated region/marker