Fgl2 MGI Mouse Gene Detail - MGI:103266 - fibrinogen-like protein 2

Symbol

Fgl2
Name

fibrinogen-like protein 2

Feature Type

protein coding gene
IDs

MGI:103266
NCBI Gene: 14190
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:21577671-21583384 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 9.83 cM
Mapping Data

10 experiments

SNPs within 2kb

263 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103266	protein coding gene	Chr5:21577640-21583384 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029316	protein coding gene	Chr5:18915252-18920995 (+)
A/J	MGP_AJ_G0029281	protein coding gene	Chr5:18308829-18314546 (+)
AKR/J	MGP_AKRJ_G0029232	protein coding gene	Chr5:19002295-19008000 (+)
BALB/cJ	MGP_BALBcJ_G0029293	protein coding gene	Chr5:18750726-18756433 (+)
C3H/HeJ	MGP_C3HHeJ_G0029012	protein coding gene	Chr5:19078720-19084435 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029746	protein coding gene	Chr5:20318107-20326720 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026985	protein coding gene	Chr5:16374008-16379746 (+)
CAST/EiJ	MGP_CASTEiJ_G0028424	protein coding gene	Chr5:18391557-18398870 (+)
CBA/J	MGP_CBAJ_G0028979	protein coding gene	Chr5:20525701-20531412 (+)
DBA/2J	MGP_DBA2J_G0029131	protein coding gene	Chr5:18588866-18594588 (+)
FVB/NJ	MGP_FVBNJ_G0029089	protein coding gene	Chr5:18005683-18011392 (+)
LP/J	MGP_LPJ_G0029215	protein coding gene	Chr5:19330628-19336359 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029117	protein coding gene	Chr5:21828106-21833712 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029779	protein coding gene	Chr5:18667310-18673041 (+)
PWK/PhJ	MGP_PWKPhJ_G0028147	protein coding gene	Chr5:17639255-17645025 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027980	protein coding gene	Chr5:18021506-18027190 (+)
WSB/EiJ	MGP_WSBEiJ_G0028504	protein coding gene	Chr5:18726173-18732821 (+)

Human Ortholog

FGL2, fibrinogen like 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FGL2, fibrinogen like 2
Synonyms

pT49, T49
Links

HGNC:3696

NCBI Gene ID: 10875

neXtProt AC: NX_Q14314

UniProt: Q14314
Chr Location

7q11.23; chr7:77193369-77199848 (-) GRCh38

MGI Vertebrate Homology

Fgl2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FGL2
Gene Tree

Fgl2

Diseases

1 with Fgl2 mouse models

Human Disease

Mouse Models

autoimmune glomerulonephritis

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

33 phenotypes from 2 alleles in 4 genetic backgrounds
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Endonuclease-mediated

7
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

4 involving Fgl2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice for one allele have unaltered type 1 immunity responses. Homozygous null mice for another allele show partial embryonic lethality, hemorrhage at implantation sites, decreased susceptibility to hepatitis virus infection and prolongedsurvival of heart grafts.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

786
Tissues

35
cDNA Data

24
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fgl2

ZFIN fgl2a

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All Sequences

39
RefSeq

2
UniProt

2
CCDS

CCDS19103.1

Ensembl

ENSMUSG00000039899 (Evidence)
NCBI Gene

14190

			Length	Strain/Species	Flank
genomic	14190	NCBI Gene Model \| MGI Sequence Detail	5714	C57BL/6J	± kb
transcript	NM_008013	RefSeq \| MGI Sequence Detail	3769	ZRU/MplStud
polypeptide	P12804	UniProt \| EBI \| MGI Sequence Detail	432	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007509 fibroleukin

(term hierarchy)
InterPro Domains

IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain

IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1

IPR020837 Fibrinogen, conserved site

IPR050373 Fibrinogen C-terminal domain-containing protein

IPR036056 Fibrinogen-like, C-terminal
GlyGen

P12804 5 sites, 3 N-linked glycans (3 sites)

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All nucleic 28

Genomic 2

cDNA 24

Primer pair 2

Microarray probesets 5

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MGD-MRK-24145, MGI:2140850

Summaries

All 84

Developmental Gene Expression 5

Diseases 2

Gene Ontology 5

Phenotypes 37
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:352255 Galpin KJC, et al., FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models. Sci Rep. 2024 Jan 8;14(1):787

TSS for Fgl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45325	Chr5:21577694-21577712 (+)	32 bp
Tssr45326	Chr5:21580436-21580447 (+)	2,771 bp
Tssr45327	Chr5:21580718-21580729 (+)	3,053 bp
Tssr45328	Chr5:21580750-21580772 (+)	3,090 bp
Tssr45329	Chr5:21581486-21581498 (+)	3,821 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24